<i>Mycoplasma pneumoniae</i>detection causes excess antibiotic use in Norwegian general practice: a retrospective case–control study

Foshaug, Mats; Vandbakk-Rüther, Maria; Skaare, Dagfinn; Grude, Nils; Lindbæk, Morten

doi:10.3399/bjgp15x683509

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…According to the Cochrane review concluded in 2015, there was not enough evidence to make a specific conclusion about the antibiotic treatment of M. pneumoniae infection [ 9 ]. Placebo-controlled trials have been suggested [ 9 , 18 , 19 ]. However, our results indicated that it might not be ethically acceptable to perform placebo-controlled trials in M. pneumoniae infections, at least in a hospital-based setting.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma pneumoniae may cause dyspnoea and hospitalisations in young healthy adults

Metsälä

Ala-Korpi

Rannikko

et al. 2021

Eur J Clin Microbiol Infect Dis

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Polymerase chain reaction (PCR)-based diagnostics for Mycoplasma pneumoniae (M. pneumoniae) from the respiratory tract has become widely available, but the interpretation of the results remains unclear. M. pneumoniae has been suggested to cause mainly mild and self-limiting infections or asymptomatic carriage. However, systematic analyses of the association between PCR results and clinical findings are scarce. This study aimed to clarify the clinical features of PCR-positive M. pneumoniae infections in a hospital setting. We reviewed 103 PCR-positive patients cared for in a university hospital during a 3-year period. Data on age, sex, health condition, acute symptoms, other pathogens found, laboratory and X-ray results and treatments were collected. Over 85% of the patients had a triad of typical symptoms: fever, cough and shortness of breath. Symptoms in the upper respiratory tract were rare. In 91% of the cases, M. pneumoniae was the only pathogen found. The highest incidence was found in the age group of 30–40 years, and 68% of the patients did not have any underlying diseases. Most patients were initially empirically treated with beta-lactam antibiotics and needed 2–4 changes in their treatment. Only 6% were discharged without an antibiotic effective against M. pneumoniae. This study shows that M. pneumoniae often led to hospitalisation and that patients needed appropriate antimicrobial treatment to recover. Mixed infections were rare, and situations that could be interpreted as carriage did not occur.

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Section: Discussionmentioning

confidence: 99%

Mycoplasma pneumoniae may cause dyspnoea and hospitalisations in young healthy adults

Metsälä

Ala-Korpi

Rannikko

et al. 2021

Eur J Clin Microbiol Infect Dis

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“…Den forrige store mycoplasmaepidemien i 2011 medførte et betydelig overforbruk av makrolidantibiotika (4 …”

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2015

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Assessing the potential of upper respiratory tract point-of-care testing: a systematic review of the prognostic significance of upper respiratory tract microbes

Thornton

Turner

Harrison

et al. 2019

Clinical Microbiology and Infection

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a b s t r a c tObjectives: Microbial point-of-care testing (POCT) has potential to revolutionize clinical care. Understanding the prognostic value of microbes identified from the upper respiratory tract (a convenient sampling site) is a necessary first step to understand potential for upper respiratory tract POCTs in assisting antimicrobial treatment decisions for respiratory infections (RTIs). The aim was to investigate the relationship between upper respiratory tract microbial detection and disease prognosis, including effects of antimicrobial use. Methods: Data sources were the MEDLINE and Embase databases. Study eligibility criteria consisted of quantitative studies reporting microbiological and prognostic data from patients of all age groups presenting with RTI. Patients presenting to healthcare or research settings with RTI participated. Interventions included upper respiratory tract swab. The methods used were systematic review and meta-analysis. Results: Searches identified 5156 articles, of which 754 were duplicates and 4258 excluded on title or abstract. A total of 144 full texts were screened; 21 articles were retained. Studies reported data for 15 microbes and 26 prognostic measures (390 potential associations). One hundred and seven (27%) associations were investigated statistically, of which 38 (36%) were significant. Most studies reported only prognostic value of test positive results. Meta-analyses suggested hospitalization duration was longer for patients with respiratory syncytial virus than adenovirus and influenza, but significant heterogeneity was observed between studies. Conclusions: A quarter of potential prognostic associations have been investigated. Of these, a third were significant, suggesting considerable potential for POCT. Future research should investigate prognostic value of positive and negative tests, and interactions between test results, use of antimicrobials and microbial resistance.

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Mycoplasma pneumoniaedetection causes excess antibiotic use in Norwegian general practice: a retrospective case–control study

Cited by 4 publications

References 17 publications

Mycoplasma pneumoniae may cause dyspnoea and hospitalisations in young healthy adults

Mycoplasma pneumoniae may cause dyspnoea and hospitalisations in young healthy adults

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Assessing the potential of upper respiratory tract point-of-care testing: a systematic review of the prognostic significance of upper respiratory tract microbes

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