<i>Mycoplasma pneumoniae</i> induced popliteal artery thrombosis treated with urokinase

Joo, Chan Uhng; Kim, J S; Han, Young Min

doi:10.1136/pmj.77.913.723

Cited by 18 publications

(15 citation statements)

References 4 publications

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“…Other case reports in the pediatric literature that found antiphospholipid antibodies include a patient with cardiac thrombus and internal carotid artery occlusion (11,12). However, in their report of right popliteal artery thrombosis in a 5-year-old male child with M. pneumoniae pneumonia and right popliteal artery thrombosis, Joo et al (13) did not find abnormalities in their limited hypercoagulability workup.…”

Section: Discussionmentioning

confidence: 90%

Interval development of multiple sub-segmental pulmonary embolism in Mycoplasma pneumoniae bronchiolitis and pneumonia

Bui¹,

Bhatia²,

Saeed³

2015

Southwest J Pulm Crit Care

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Introduction: Cases of pulmonary embolism (PE) concurrent with Mycoplasma pneumoniae infection are rare in the medical literature. We describe a patient with M. pneumoniae bronchiolitis and pneumonia who developed multiple right-sided, subsegmental PE. Case Description: A 54-year-old man presented following one week of respiratory and constitutional symptoms. He was admitted for respiratory distress and started on ceftriaxone, azithromycin, and oseltamivir. Because of a lack of clinical improvement, antibiotics were escalated to vancomycin and piperacillin-tazobactam. M. pneumoniae IgM and IgG serologies returned positive, and antibiotics were narrowed to azithromycin, with clinical improvement and gradual decrease in supplemental oxygen requirement. One week into the hospitalization, the patient abruptly developed an increased oxygen requirement. Computed tomography angiography (CTA) of the chest found stable M. pneumoniae bronchiolitis and pneumonia and the interval development of multiple right-sided, sub-segmental PE. He was treated with unfractionated and then low-molecular-weight heparin as a bridge to warfarin, azithromycin, and a prednisone taper. In the outpatient setting, repeat CTA revealed resolution of M. pneumoniae infection and PE. Discussion: Although the mechanism and association are unclear, other case reports have proposed that M. pneumoniae infection promotes hypercoagulability or a prothrombotic state, predisposing patients to thromboembolism. In a patient with M. pneumoniae infection who develops sudden respiratory distress or failure despite appropriate treatment, clinicians should have a high suspicion for PE, and a CTA should be considered as part of further evaluation.

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Section: Discussionmentioning

confidence: 90%

Interval development of multiple sub-segmental pulmonary embolism in Mycoplasma pneumoniae bronchiolitis and pneumonia

Bui¹,

Bhatia²,

Saeed³

2015

Southwest J Pulm Crit Care

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“…3 What is not known is the fraction of patients with mycoplasma who develop aPL. Given the propensity for this organism to trigger other auto immune responses such as a cold agglutinin response in 70% 5 and other case reports of patients developing thrombosis with mycoplasma infections 3,4 we speculate that aPL antibodies may be more common in mycoplasma infections than believed earlier. Routine screening for this antibody may help to quantify the incidence of aPL in this infection and help to plan future risk and management strategies.…”

Section: Discussionmentioning

confidence: 94%

Mycoplasma pneumonia with antiphospholipid antibodies and a cardiac thrombus

Bakshi

Khemani

Vishwanathan

et al. 2006

Lupus

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“…In our research, 13 cases (18.84%) of FMPP complicated with liver function damage (P < 0.05). Moreover, M. pneumoniae infection might contribute to hypercoagulability and cause thrombosis itself, which was serious extrapulmonary complication [14] . In our research, 13 cases (18.84%) of FMPP had embolism (P < 0.01).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors of Fulminant Mycoplasma pneumoniae pneumonia in children

Ling

Zhang

Zhu

et al. 2020

Preprint

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BACKGROUND: Analyze the clinical characteristics of Fulminant Mycoplasma pneumoniae pneumonia (FMPP), and explore the related factors predicting FMPP. METHODS: A retrospective case-control study was performed on 345 children with Mycoplasma pneumoniae pneumonia (MPP) hospitalized in our Hospital from January 2017 to June 2019. The clinical features, laboratory data and radiological findings were compared between the FMPP group, refractory Mycoplasma pneumoniae pneumonia (RMPP)group and general Mycoplasma pneumoniae pneumonia (GMPP) group. RESULTS: FMPP patients (n=69) had more severe presentations, higher incidence of extra-pulmonary complications and more serious radiological findings(P<0.05). And the days of fever and the days in hospital were longer, and FMPP patients also need more complicated treatments(P<0.05). Meanwhile, the levels of white blood cell count(WBC) ,C-reactive protein(CRP), lactic dehydrogenase (LDH), interleukin (IL)-6,ferritin, D-dimer, fibrinogen(FG),alanine aminotransferase(ALT) and the percentage of neutrophils in the FMPP group were significantly higher than those in the RMPP group and the GMPP group (both P<0.05). In ROC curve analysis, the percentage of neutrophils, WBC, CRP, LDH, IL-6, ferritin, D-dimer and ALT were contributed to identify FMPP patients. Multivariate logistic regression analysis showed that ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion had significant predictive effects on the early diagnosis of FMPP (P<0.01). Conclusion: FMPP patients presented more serious clinical manifestations. Ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion were high risk factors for FMPP.

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Mycoplasma pneumoniae induced popliteal artery thrombosis treated with urokinase

Cited by 18 publications

References 4 publications

Interval development of multiple sub-segmental pulmonary embolism in Mycoplasma pneumoniae bronchiolitis and pneumonia

Interval development of multiple sub-segmental pulmonary embolism in Mycoplasma pneumoniae bronchiolitis and pneumonia

Mycoplasma pneumonia with antiphospholipid antibodies and a cardiac thrombus

Clinical characteristics and risk factors of Fulminant Mycoplasma pneumoniae pneumonia in children

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