<i>Mycoplasma pneumoniae</i> infection: Basics

Saraya, Takeshi

doi:10.1002/jgf2.15

Cited by 42 publications

(36 citation statements)

References 60 publications

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“…Pneumonia is a lung parenchyma infection that is prevalent in any age group and is known as the sixth cause of death and the most common death-related infectious syndrome (1,2). Atypical Pneumonia syndrome causes upper and lower respiratory tract infection that can be characterized by gradual onset, dry cough, shortness of breath, extraterrestrial symptoms (such as headache, muscle aches, fatigue, sore throat, nausea, vomiting, and diarrhea) (3)(4)(5). Mycoplasma pneumoniae is a major cause of community-acquired pneumonia.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Atypical Pneumonia Caused by Mycoplasma pneumoniae (P1 gene) in Patients with Respiratory Infections by Culture and Molecular PCR Methods in Tehran, Iran

Babaei

Pouladi

Ashtari

et al. 2020

Jundishapur J Microbiol

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Background: Atypical pneumonia is an upper and lower respiratory tract infection. Mycoplasma pneumoniae is a major cause of community-acquired pneumonia (CAP). Objectives: The present study aimed to determine the prevalence of atypical pneumonia caused by M. pneumonia by culture and molecular PCR methods in Tehran. Methods: In the present study, 102 samples of throat swab were collected from patients with respiratory infections. All samples were cultured in liquid PPLO Broth And solid PPLO agar media (1% glucose and 20% horse serum). The PCR technique with specific primers was implemented after culture and genome extraction through phenol-chloroform technique. Results: In this study, 27 (26.47%) colonies of Mycoplasma were isolated on PPLO agar medium. Using specific primers, it was found that 33 samples (32.4%) were positive in terms of Mycoplasma genus and 14 samples (13.7%) were positive for the presence of M. pneumonia. Conclusions: Mycoplasma pneumonia is a pathogen that causes respiratory tract infections in humans. Molecular PCR method is a quick and sensitive technique that has higher sensitivity and specificity than other methods. The obtained results may contribute to the specific treatment of some patients with symptoms of respiratory infections. Informed Consent:Patients were recruited through a complete and informed questionnaire, followed by a complete description of the research and complete patient satisfaction.

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Section: Introductionmentioning

confidence: 99%

The Prevalence of Atypical Pneumonia Caused by Mycoplasma pneumoniae (P1 gene) in Patients with Respiratory Infections by Culture and Molecular PCR Methods in Tehran, Iran

Babaei

Pouladi

Ashtari

et al. 2020

Jundishapur J Microbiol

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“…Moreover, the widespread application of these drugs has led to elevated rate of ML-resistant M. pneumoniae (MRMP) throughout the world (7,12,13). MRMP infection has been shown to cause prolonged treatment, persistent cough, and an elevated time of fever reduction compared with those infections sensitive to treatment (14,15). Currently, the MRMP has been reported more than 90% in Asia and 26% in the Europe (7,8,16).…”

Section: Introductionmentioning

confidence: 99%

Molecular detection and evaluation of resistance of Mycoplasma Pneumoniae to macrolide (Erythromycin) due to mutation in the 23S rRNA gene among Iranian Patients with respiratory infections

Niakan

Rostampur

Mirnejad

et al. 2020

Preprint

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Objective: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia. The global increased resistance of M. pneumoniae strains to macrolide (ML) has become a worrisome health problem. The widespread use of these drugs has led to increased rate of reported ML-resistant M. pneumoniae (MRMP) throughout the world. Therefore, this study was aimed to evaluate the resistance of M. pneumoniae against erythromycin due to mutations in the 23S rRNA gene of patients with respiratory infections in Iran.Results: According to the findings of the present study, employing specific primers showed that 17 cases (17%) were positive for mycoplasma genus and 6 cases (6%) positive for M. pneumoniae species. Also, analysis of the sequence of 23S rRNA gene, revealed that one of the samples had mutations at positions A2431G and G2491A. Measuring the minimum inhibitory concentration (MIC), revealed that all samples positive for M. pneumoniae with 23S rRNA gene were sensitive to erythromycin, and no ML resistance was reported.

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“…Mycoplasma pneumoniae is one of the most common pathogens in community-acquired pneumonia (CAP), determined in 41.1% of pediatric and 13.0% of adult CAP cases in Japan. 1,2 Most available antimicrobial agents, especially beta-lactam agents, 3 are not effective against M. pneumoniae; 4 thus, risk factors and clinical manifestations have been intensively investigated. Till date, school-aged children and adolescents, 3 persistent cough, 5 vomiting or diarrhea, 6 and autumn or winter outbreak 7 have been identified as factors associated with M. pneumoniae infections.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and seasonal variations in the prevalence of macrolide‐resistant Mycoplasma pneumoniae

Akashi

Hayashi

Suzuki

et al. 2018

J of Gen and Family Med

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Background Mycoplasma pneumoniae is a common pathogen causing pneumonia; macrolide‐resistant strains are rapidly spreading across Japan. However, the clinical features of macrolide‐resistant M. pneumoniae pneumonia have not been well established. Here, we evaluated the clinical characteristics and seasonal variations in the prevalence of M. pneumoniae with macrolide‐resistant mutations (MRM).MethodsThe monthly prevalence of MRM in M. pneumoniae strains isolated from May 2016 to April 2017 was retrospectively analyzed, and the clinical characteristics of pneumonia cases with MRM were compared to those of cases without MRM. The M. pneumoniae isolates and point mutations at site 2063 or 2064 in domain V of 23S rRNA were evaluated by the GENECUBE system and GENECUBE Mycoplasma detection kit.Results Mycoplasma pneumoniae infection was identified in 383 cases, including 221 cases of MRM (57.7%). The MRM prevalence was 86.3% (44/51) between May and July 2016, demonstrating an apparent decrease in September 2016, subsequently reaching 43.0% (34/79) in November 2016. Mycoplasma pneumoniae pneumonia was diagnosed in 275 cases, including 222 pediatric and 53 adult cases. Macrolide use preceding evaluation was found to be the only feature of MRM pneumonia cases both in children (odds ratio [OR] 3.86, 95% confidence interval [CI]:1.72–8.66) and in adults (OR 7.43, 95% CI: 1.67–33.1).ConclusionsThe determination rate of MRM varied widely throughout the year, and our study demonstrated the challenges in predicting M. pneumoniae with MRM based on clinical features at diagnosis. Therefore, continuous monitoring of the prevalence of MRM is warranted, which may help in selecting an effective treatment.

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Mycoplasma pneumoniae infection: Basics

Cited by 42 publications

References 60 publications

The Prevalence of Atypical Pneumonia Caused by Mycoplasma pneumoniae (P1 gene) in Patients with Respiratory Infections by Culture and Molecular PCR Methods in Tehran, Iran

The Prevalence of Atypical Pneumonia Caused by Mycoplasma pneumoniae (P1 gene) in Patients with Respiratory Infections by Culture and Molecular PCR Methods in Tehran, Iran

Molecular detection and evaluation of resistance of Mycoplasma Pneumoniae to macrolide (Erythromycin) due to mutation in the 23S rRNA gene among Iranian Patients with respiratory infections

Clinical features and seasonal variations in the prevalence of macrolide‐resistant Mycoplasma pneumoniae

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