N-[3-(Dimethylamino)propyl]-N′-(2-hydroxy-5-methylphenyl)oxamide

Abstract

Key indicators: single-crystal X-ray study; T = 296 K; mean (C-C) = 0.003 Å; R factor = 0.053; wR factor = 0.151; data-to-parameter ratio = 15.8.In the title compound, C 14 H 21 N 3 O 3 , the oxamide group has a transoid conformation. In the crystal, the molecules are connected by N-HÁ Á ÁO and O-HÁ Á ÁN hydrogen bonds into a double chain running along the b axis. Related literature

The Effect of Branched Alkyl Chain Length on the Properties of Supramolecular Organogels from Mono-N-Alkylated Primary Oxalamides

“…Given that many oxalamide compounds are biologically and pharmaceutically active [34][35][36][37][38][39][40][41][42][43][44][45], their effect on the metabolic activity of mammalian cells was evaluated. The effect of these compounds on the metabolism of bone marrow-derived mast cells (BMMCs) was evaluated using the XTT assay which measures the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent bioreductase activity of live cells, a key mitochondrial process necessary for energy generation.…”

“…Oxalamide compounds are of considerable interest due to their potential in biomedical applications [34][35][36][37][38][39][40][41][42][43][44][45], catalysis [46][47][48], foods [49], and self-assembling behavior to form gels [50][51][52][53][54][55][56]. The oxalamide functional group consists of two amide groups next to each other in reverse mode, connected by two consecutive carbonyl groups, which has been extensively used as supramolecular synthon to generate LMWGs [50][51][52][53][54][55][56][57][58].…”