<i>N</i>‐Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high‐fat diet‐fed mice

Zheng, Junping; Yuan, Xubing; Zhang, Chen; Jia, Peiyuan; Jiao, Siming; Zhao, Xiaoming; Yin, Heng; Du, Yuguang; Liu, Hongtao

doi:10.1111/1753-0407.12795

Cited by 42 publications

(39 citation statements)

References 45 publications

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“…It was interesting that, when supplemented with NAC, there was a reduction in the fasting blood glucose and an increase in insulin sensitivity. Zheng et al, (23) administered NAC orally in the drinking water for 5 months showed similar results. Obese mice that received NAC for 5 months had an improvement in fasting blood glucose and higher glucose tolerance, which reinforces the involvement of oxidative stress in the pathophysiology of insulin resistance.…”

Section: ❚ Discussionmentioning

confidence: 73%

Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice

Rodrigues

Pieri

Silveira

et al. 2020

Einstein (São Paulo)

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Section: ❚ Discussionmentioning

confidence: 73%

Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice

Rodrigues

Pieri

Silveira

et al. 2020

Einstein (São Paulo)

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“…Allobaculum is a beneficial intestinal bacterium [57,58] that produces lactic and butyric acids and small amounts of ethanol from glucose [57] and decreases glucose digestion [59]. Several studies have correlated increased abundance of Allobaculum with a lean phenotype [60] and glucose tolerance [61]. S24-7, a dominant family belonging to the class Bacteroidales, degrades complex polysaccharides into acetate, propionate, and succinate [62].…”

Section: Discussionmentioning

confidence: 99%

Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice

Liu

Gao

et al. 2020

Nutrients

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Dietary fiber, an important regulator of intestinal microbiota, is a promising tool for preventing obesity and related metabolic disorders. However, the functional links between dietary fiber, intestinal microbiota, and obesity phenotype are still not fully understood. Combined soluble fiber (CSF) is a synthetic mixture of polysaccharides and displays high viscosity, water-binding capacity, swelling capacity, and fermentability. We found that supplementing high-fat diet (HFD) with 6% CSF significantly improved the insulin sensitivity of obese mice without affecting their body weight. Replacing the HFD with normal chow basal diet (NCD), the presence of CSF in the feed significantly enhanced satiety, decreased energy intake, promoted weight and fat loss, and augmented insulin sensitivity. CSF also improved the intestinal morphological integrity, attenuated systemic inflammation, promoted intestinal microbiota homeostasis, and stabilized the production of short-chain fatty acids (SCFAs) that was perturbed during HFD-induced obesity, and these stabilizing effects were more prominent when the basal diet was switched to NCD. The enrichment of bacteria of the S24-7 family and Allobaculum genus increased markedly in the intestine following 6% CSF supplementation- and correlated with decreased adiposity and insulin resistance. Five bacterial genera that were decreased by CSF, including Oscillospira, unclassified Lachonospitaceae, unclassified Clostridiales, unclassified Desulfovibrionaceae, and unclassified Ruminococcae, were subjected to co-occurrence network analysis and were positively correlated to adiposity and insulin resistance, indicating a key role in the microbial response to CSF. Thus, CSF has a potential to promote insulin sensitivity and even reduce obesity via beneficial regulation of the gut microecosystem.

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“…Allobaculum is a putative beneficial bacteria able to produce short‐chain fatty acid (SCFA), which are shown to deliver multiple systemic and targeted benefits to the mammalian host. Several studies reported that Allobaculum genus was selectively enriched when mice were treated with berberine, calorie restriction or N‐acetyl cysteine to reduce weight gain or to improve metabolism. Also, a recent study reported Allobaculum , together with Lactobacillus , Candidatus Arthromitus , segmented filamentous bacteria were four dominant candidate protective taxa in young mice.…”

Section: Discussionmentioning

confidence: 99%

Synbindin deficiency inhibits colon carcinogenesis by attenuating Wnt cascade and balancing gut microbiome

Ren

et al. 2019

Intl Journal of Cancer

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The molecular mechanisms that control the development of colorectal cancer (CRC) remain poorly defined. Here we show Synbindin promoted CRC oncogenesis by activating Wnt signaling and altering gut microbiome. Synbindin upregulation in human CRCs was associated with poor patient prognosis. Intestine‐specific disruption of Synbindin balanced the disturbed gut microbiota and protected mice against tumor formation in the colitis‐associated cancer (CAC) model. The protective role was compromised after gut microbiota depletion. In host, increased goblet cells and mucin2 expression, together with increased intestinal epithelial cells (IECs) apoptosis and decreased epithelial proliferation were observed. Further transcriptomic sequencing identified Wnt signaling a major regulatory node downstream of Synbindin. Combined molecular and cellular characterizations revealed that Synbindin confers Disheveled‐3 (DVL3)‐based signalosome assembly and acts as a modular scaffold for DVL3 and Axin2 complex, orchestrating the intensity of Wnt signaling. These findings identify a critical role of Synbindin in gut microbiome composition and Wnt signaling activation in colorectal carcinogenesis, and highlight Synbindin as an adaptor protein with multifaceted roles.

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N‐Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high‐fat diet‐fed mice

Abstract: N-Acetylcysteine may be a potential drug to prevent glucose metabolic disturbances by reshaping the structure of the gut microbiota.

Cited by 42 publications

References 45 publications

Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice

Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice

Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice

Synbindin deficiency inhibits colon carcinogenesis by attenuating Wnt cascade and balancing gut microbiome

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