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            -Acetylcysteine Enhances Hippocampal Neuronal Survival After Transient Forebrain Ischemia in Rats

Knuckey, Neville W.; Palm, Donald E.; Primiano, Michael J.; Epstein, Miran; Johanson, Conrad E.

doi:10.1161/01.str.26.2.305

Cited by 81 publications

(46 citation statements)

References 36 publications

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“…Santral sinir sistemi üzerine olumlu etkileri özellikle birçok deneyde hayvanlar üzerinde araştırılmıştır. [21][22][23] Sekhon ve ark.nın [21] yaptıkları çalışmada anestezi verilmiş fare modellerinde orta serebral arter oklüde edilmiş, böylece fokal serebral iskemi oluşturulmuştur. N-asetilsistein verilen hayvan grubunda, tedavi verilmeyen gruba göre beyin enfarkt volümünde %49.7 oranın-da azalma, nörolojik iyileşmede %50 artış gözlenmiştir.…”

Section: Discussionunclassified

“…Knuckey ve ark.nın [23] yine sıçanlarda kafa travması, kardiyak arrest ve şok durumlarında görülen geçici ön beyin iskemisi modelinde, NAC verilen grup kontrol grubuyla karşılaştırıldığında nöron sağkalımının önem-li derecede arttığı görülmüştür.…”

Section: Discussionunclassified

“…[7][8][9][10] Çalışmamızda KABG ameliyatı geçiren hastalarda NAC'nin nörolojik komplikasyonlar üzerine olumlu etkileri araştırıldı. Daha önce yapılan çalışmalarla paralel olarak NAC uygulanmayan kontrol grubunda ameliyat sonrası nörokognitif fonksiyon testlerinde ameliyat öncesi olanlara göre anlamlı skor düşüşleri olduğu görüldü.…”

Section: Discussionunclassified

“…[5,6] Santral sinir sistemi üze-rine olumlu etkileri özellikle birçok deneyde hayvanlar üzerinde araştırılmış, iskemi sonrası reperfüzyonla oluşan beyin enfarkt alanlarını azalttığı ve nörolojik iyileşmeyi hızlandırdığı gösterilmiştir. [7][8][9][10] Bu çalışmada, koroner arter baypas greft (KABG) ameliyatı geçiren, NAC uygulanan ve uygulanmayan hastalarda ameliyat öncesi ve sonrası nörokognitif fonksiyonlar karşılaştırıldı. Bu çalışmada, çeşitli organ sistemlerindeki reperfüzyon hasarına olumlu etkileri gösterilmiş olan NAC'nin KABG ameliyatı sonrası nörokognitif fonksiyonlar üzerine olumlu etkileri ve nörolojik hasarı önleyip önleyemeyeceği araştırıldı.…”

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Effects of N-acetylcysteine on neurocognitive functions after coronary artery bypass graft surgery

Unlu¹

2013

Turk Gogus Kalp Dama

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Section: Discussionunclassified

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Effects of N-acetylcysteine on neurocognitive functions after coronary artery bypass graft surgery

Unlu¹

2013

Turk Gogus Kalp Dama

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“…The neuroprotective effect of NAC has been demonstrated in ischemia and ischemia/reperfusion models [2][3][4][5] , and in traumatic injury of the nervous system [6] . NAC is also thought to play a possible beneficial role in age-associated neurodegenerative diseases [7] .…”

Section: Introductionmentioning

confidence: 99%

Neuron differentiation and neuritogenesis stimulated by N-acetylcysteine (NAC)

Qian

Yang

2009

Acta Pharmacol Sin

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Aim:To investigate the effect of N-acetylcysteine (NAC), a potent antioxidant, on neuron differentiation of cultured mouse embryonic stem cells (ESCs) induced by retinoic acid (RA) in vitro. Superior cervical ganglion (SCG) neurons were used to study the effect of NAC on neuritogenesis. Methods: Immunoblotting was performed to detect the expression of microtubule-associated protein 2 (MAP2). MTT assays were used to determine cell viability. Cell death was estimated with trypan blue exclusion and Hoechst 33342 staining. Immunocytochemical analysis was carried out to identify neurons. Results: We obtained a high percentage of MAP2-positive neurons derived from embryoid bodies (EBs) induced by RA by administering 1 mmol/L NAC at differentiation day 0. On differentiation day 8, the expression of MAP2 protein was strongly upregulated in the presence of NAC. NAC promoted neuron differentiation of ES cells in a dose-and time-dependent manner. Notably, NAC suppressed cell death caused by RA during neuron differentiation. In addition, neurite extension of SCG neurons was greatly stimulated in the presence of NAC. Conclusion: These results show that NAC enhanced both neuron differentiation and neuritogenesis, suggesting that it may be used in the development of novel therapeutic approaches targeting neuron loss and neurite dystrophy in neurodegenerative diseases.

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S-nitroso-n-acetylcysteine protects skeletal muscle against reperfusion injury

et al. 1998

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The effects of a nitric oxide (NO) donor on microcirculation and contractile function of reperfused skeletal muscle were studied. Rat cremaster muscles underwent 5 hours of ischemia and 90 minutes of reperfusion and were divided into two groups systemically infused with S-nitroso-N-acetylcysteine (SNAC, 100 nmol/min) and phosphate-buffered saline (PBS), respectively. The results showed that the vessels in the SNAC group had more rapid and complete recovery than that in controls. A significant difference was found from 10 to 40 minutes and at 90 minutes in 10-20-microm arterioles, from 10 to 90 minutes in 20-40-microm arterioles, and at 10 and 90 minutes in 40-70-microm arteries. When compared to controls, SNAC-treated muscles showed larger fluorescein filling areas at 15, 30, 60, and 90 minutes and greater isometric tetanic contractile forces in response to stimulation frequencies of 40, 70, 100, and 120 Hz. The data indicate that supplementation of exogenous NO could effectively improve microcirculation and contractile function of skeletal muscle during early reperfusion.

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N -Acetylcysteine Enhances Hippocampal Neuronal Survival After Transient Forebrain Ischemia in Rats

Cited by 81 publications

References 36 publications

Effects of N-acetylcysteine on neurocognitive functions after coronary artery bypass graft surgery

Effects of N-acetylcysteine on neurocognitive functions after coronary artery bypass graft surgery

Neuron differentiation and neuritogenesis stimulated by N-acetylcysteine (NAC)

S-nitroso-n-acetylcysteine protects skeletal muscle against reperfusion injury

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