N‐Benzylation/Benzylic CH Amidation Cascade by the (η³‐Benzyl)palladium System in Aqueous Media: An Effective Pathway for the Direct Construction of 3‐Phenyl‐3,4‐dihydro‐ (2H)‐1,2,4‐benzothiadiazine 1,1‐Dioxides

Abstract

We demonstrate a unique strategy for a benzylation/benzylic C À H amidation cascade reaction by the (h 3

Synthesis, Structures of Benzoxazolyl Iridium(III) Complexes, and Applications on C–C and C–N Bond Formation Reactions under Solvent-Free Conditions: Catalytic Activity Enhanced by Noncoordinating Anion without Silver Effect

“…The borrowing hydrogen methodology involves (1) oxidation of alcohols or ammonia to the corresponding carbonyl compounds or imines; (2) alkylation of ketones, alcohols, or amines to form unsaturated carbonyl compounds or imines; and (3) reduction of the C–C or C–N bonds using the borrow hydrogen atoms from alcohols or amines (Scheme ). , Generally, among these transformations, the catalyst plays a crucial role in every step. To date, although some metals (Pd, Au, Ag, Cu, Fe, Ni, Os, and Rh,) have been studied, Ru and Ir − are still shown to be the most effective and promising catalysts for C-alkylation and N-alkylation.…”

Iron-catalyzed oxidative synthesis of N-heterocycles from primary alcohols

“…18 Very recently, a Pd-catalyzed synthetic route was developed for the preparation of benzothiadiazine derivatives by using o-aminobenzene-sulfonamide and primary alcohols as starting materials. 19 Generally, these compounds were prepared from o-amino-benzenesulfonamide by condensation with aldehydes or ethyl hemiacetals in acidic medium. 20 As shown in Table 4, using the present system, the nal products, cyclic aminals (7) without C]N bond formation were obtained.…”

Direct Use of Benzylic Alcohols for Multicomponent Synthesis of 2‐Aryl Quinazolinones Utilizing the π‐Benzylpalladium(II) System in Water

“…We have been developing environmentally benign benzylic CÀ H functionalizations at sites adjacent to heteroatoms utilizing the π-benzylpalladium system in water. [9] The catalytic amination of CÀ H bonds is recognized as an atom-economic, straightforward and efficient method that can incorporate nitrogen into molecular frameworks without pre-activation of starting materials. [10] Herein, we present the first example of the direct use of benzylic alcohols for MCR of isatoic anhydrides with amines catalyzed by Pd(0)/ TPPMS in water, furnishing a series of 2-aryl quinazolinone derivatives (Scheme 1C).…”