N-Hydroxy-Phe-Phe, a new dipeptide, and cytotoxic macrocyclic trichothecenes from the lethal toxic mushroom Podostroma cornu-damae

Abstract

A new dipeptide, N-hydroxy-Phe-Phe (1), and three macrocyclic trichothecenes, namely satratoxin H (2), 12′-episatratoxin H (3), and roridin F (4), were isolated from a plate culture of the poisonous mushroom Podostroma cornu-damae.

Isolation of Macrocyclic Trichothecene Mycotoxins from the Lethal Toxic Mushroom Podostroma cornu-damae and Their Cytotoxic Activities

“…Satratoxin H exhibited moderate cytotoxic potency against all four cell lines, with IC50 values ranging from 1.93 to 4.22 µM. In contrast, roridin F did not show significant cytotoxicity (IC50, >10.0) [25]. The observed potent cytotoxicity of 12′-episatratoxin H compared to satratoxin H aligns well with previous data despite differences in the tested cancer cell lines.…”

“…These results highlight the efficient targeted toxicity of compounds 7 and 8 toward breast cancer cells. In our recent study [25], we evaluated the cytotoxicity of satratoxin H, 12 ′ -episatratoxin H, and roridin F against four human-derived cancer cell lines: SK-OV-3 (ovary malignant ascites), A549 (non-small cell lung carcinoma), SK-MEL-2 (skin melanoma), and HCT (colon adenocarcinoma). The assessment was conducted using the sulforhodamine B (SRB) bioassay [25], with doxorubicin serving as the positive control.…”

“…In our recent study [25], we evaluated the cytotoxicity of satratoxin H, 12 ′ -episatratoxin H, and roridin F against four human-derived cancer cell lines: SK-OV-3 (ovary malignant ascites), A549 (non-small cell lung carcinoma), SK-MEL-2 (skin melanoma), and HCT (colon adenocarcinoma). The assessment was conducted using the sulforhodamine B (SRB) bioassay [25], with doxorubicin serving as the positive control. Results showed that 12 ′ -episatratoxin H demonstrated potent cytotoxic effects against all four tested cell lines, with IC 50 values ranging from 0.7 to 2.8 nM, surpassing those of doxorubicin.…”