N,N′,N′′-Trisubstituted guanidine derivatives as DNA-intercalators: synthesis, crystal structures and biophysical investigations

Abstract

Three new N,N’,N’’-trisubstituted guanidine derivatives (L1, L2 and L3) were synthesized and characterized using NMR and mass spectral studies. The structure of these ligands has been confirmed using single-crystal XRD...

Zn(ii) and Cd(ii) pincer complexes bearing meta alkylated pyridinium amidates; synthesis & preliminary anticancer studies

“…Whereas compounds that interact mainly in the DNA grooves by partial and/or non-classical intercalation, predictably affect less obvious (positive or negative) or no change in DNA viscosity. 48 The relative viscosity of the CT-DNA solutions increased or remained constant, to a small extent, with increasing concentrations of the original compound's solution, presented in Fig. S10 (ESI†).…”