N-o-Vanillylidene-l-histidine: Experimental Charge Density Analysis of a Double Zwitterionic Amino Acid Schiff-Base Compound

Abstract

A double zwitterionic Schiff base was synthesized using the amino acid L-histidine and o-vanillin (2-hydroxy-3methoxy benzaldehyde). Both the phenol and carboxyl groups are deprotonated, and the imine nitrogen atom and histidineimidazole ring are protonated to give the double zwitterion with an intramolecular (imine)N-H þ 3 3 3 -O(phenol) hydrogen bond (ketoamine form). Such a ketoamine form in a double zwitterion is assumed in the catalytic cycle of enzymatic transformations of amino acids with the cofactor (vitamin B6) pyridoxal-5 0 -phosphate (PLP). A high-resolution, lowtemperature, single-crystal X-ray diffraction data set on N-o-vanillylidene-L-histidine (also named 3-methoxysalicylidene-Lhistidine or N-(2-oxy-3-methoxy-benzylidene)-L-histidine, OVHIS) is used in the analysis of molecular electrostatic properties and intermolecular interactions. All oxygen atoms in the molecule (four in total) are mutually almost coplanar and located (externally) on the same side of molecule. These four O atoms carry significant negative charge and form a large area of strong negative electrostatic potential (appropriate for bonding to a metal atom). The protonated and, thus, positively charged imidazole ring is situated on the opposite side of the molecule from the area of the O atoms. Consequently, the OVHIS molecule is highly polarized and has a very high molecular dipole moment of 42.4 D in the solid state (calculated from experimental X-ray data). Two strong intermolecular charge-assisted N-H þ 3 3 3 -O hydrogen bonds (with H 3 3 3 O distances of 1.61 A ˚) together with other D-H 3 3 3 O interactions (D = N, C) contribute to a large molecular dipole enhancement which occurs upon crystallization. The topologies of the bonding within the molecule as well as its hydrogen bonds have been investigated according to Bader's quantum theory of atoms in molecules (QTAIM). 1 H solid-state magic angle spinning nuclear magnetic resonance (MAS NMR) was used to confirm the zwitterionic structure in the solid state.

A Cadmium Anionic 1-D Coordination Polymer {[Cd(H2O)6][Cd2(atr)2(μ2-btc)2(H2O)4] 2H2O}n within a 3-D Supramolecular Charge-Assisted Hydrogen-Bonded and π-Stacking Network

“…The carboxylate groups of btc 3´a s hydrogen bond acceptors carry negative ionic charges. Such charge-assisted H-bonds are usually stronger and shorter than neutral H-bonds [37][38][39][40][41][42]. (5) 2.785 (7) 167 (8) vi = −x + 1, y + 1/2, −z + 3/2 O9-H9B···N2 ii 0.89 (9) 2.02 (9) 2.897 (8) 171 (8) ii = −x + 1, −y + 1, −z + 1 O10-H10A···O6 0.95 (9) 1.84 (9) 2.742 (7) 158 (7) -O10-H10B···N4 vii 0.98 (5) 1.91 (6) 2.803 (8) 151 (7) vii = −x + 2, −y + 1, −z + 2 O11-H11A···O6…”

Metal ion binding patterns of acyclovir: Molecular recognition between this antiviral agent and copper(II) chelates with iminodiacetate or glycylglycinate

“…Hence the crystal of 1 is a H-bonded 3D-framework. It should be noted that the referred hydrogen bonds are charged-assisted, which are generally one of the strongest, wherein the H-bond donor and/or acceptor carry positive and negative ionic charges respectively [39][40][41][42][43].…”

Charge-Assisted Hydrogen-Bonded Networks of NH4+ and [Co(NH3)6]3+ with the New Linker Anion of 4-Phosphono-Biphenyl-4′-Carboxylic Acid

“…Finally, we note that in both structures, 1 and 2, the H-bonds to the phosphonato groups are so-called charge-assisted hydrogen bonds. The hydrogen bond donor and/or acceptor carry positive and negative ionic charges, respectively, hence are usually stronger and shorter than neutral H-bonds [12,46,47,[50][51][52][53][54]. In 1 these are bonds NH 4 (+)¨¨¨p´q O-P and NH 4 (+)¨¨¨( H)O-P, -P-OH¨¨¨p´qO-P (Figure 1c).…”