2022
DOI: 10.1177/00220345221116927
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Ncor1 Deficiency Promotes Osteoclastogenesis and Exacerbates Periodontitis

Abstract: Nuclear receptor corepressor 1 ( Ncor1) has been reported to regulate different transcription factors in different biological processes, including metabolism, inflammation, and circadian rhythms. However, the role of Ncor1 in periodontitis has not been elucidated. The aims of the present study were to investigate the role of Ncor1 in experimental periodontitis and to explore the underlying mechanisms through an experimental periodontitis model in myeloid cell–specific Ncor1-deficient mice. Myeloid cell–specifi… Show more

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Cited by 9 publications
(3 citation statements)
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“…However, the current study has several limitations. The experimental mouse periodontitis induced by silk ligature and P. gingivalis is an acute inflammation model and causes differences in the etiological process with the chronic process of human periodontitis 54 . Moreover, the concentration we used in vivo was the same with selected in vitro, hence, the actual concentration applied in periodontal tissues was less than 1 μ M. Selecting appropriate materials and loading capsaicin to apply in gingival sulcus are further to be explored.…”
Section: Discussionmentioning
confidence: 99%
“…However, the current study has several limitations. The experimental mouse periodontitis induced by silk ligature and P. gingivalis is an acute inflammation model and causes differences in the etiological process with the chronic process of human periodontitis 54 . Moreover, the concentration we used in vivo was the same with selected in vitro, hence, the actual concentration applied in periodontal tissues was less than 1 μ M. Selecting appropriate materials and loading capsaicin to apply in gingival sulcus are further to be explored.…”
Section: Discussionmentioning
confidence: 99%
“…For example, NCOR1 interacts with LXRβ in microglia, and knockdown of NCOR1 in macrophages protects against ischemic stroke [18]. De ciency of Ncor1 in macrophages exacerbates periodontitis by regulating Cebpα transcription through PPARγ, promotting osteoclastogenesis and neutrophil accumulation in mice with experimental periodontitis [19].…”
Section: Introductionmentioning
confidence: 99%
“…For example, NCOR1 interacts with LXRβ in microglia, and knockdown of NCOR1 in macrophages protects against ischemic stroke [ 18 ]. Deficiency of Ncor1 in macrophages exacerbates periodontitis by regulating Cebpα transcription through PPARγ, promoting osteoclastogenesis and neutrophil accumulation in mice with experimental periodontitis [ 19 ]. In a previous report, macrophage NCOR1 has been shown to prevent atherosclerosis via activation of PPARγ [ 15 ].…”
Section: Introductionmentioning
confidence: 99%