<i>Neisseria meningitidis</i> carriage in Swedish teenagers associated with the serogroup W outbreak at the World Scout Jamboree, Japan 2015

Jacobsson, Susanne; Stenmark, Bianca; Hedberg, Sara Thulin; Mölling, Paula; Fredlund, Hans

doi:10.1111/apm.12819

Cited by 6 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two confirmed cases of invasive meningo coccal disease were reported from Sweden. 65 Molecular analysis [65][66][67] showed that the same N meningitides isolates were responsible for the six cases and that they belonged to the ST11 clonal complex, which is usually associated with large outbreaks. No other cases were reported from scouts who attended from other European countries or Japan.…”

Section: The 23rd World Scout Jamboreementioning

confidence: 99%

“…However, within 9 days of the end of the event, six cases of laboratoryconfirmed invasive meningococcal disease caused by Neisseria meningitides capsular serogroup W occurred among scouts and their close contacts in Scotland and Sweden. [65][66][67] Soon after return to Scotland, three scouts and one relative were diagnosed with invasive meningo coccal disease. These cases were all associated with one scout unit.…”

Section: The 23rd World Scout Jamboreementioning

confidence: 99%

See 1 more Smart Citation

Mass gatherings medicine: public health issues arising from mass gathering religious and sporting events

Memish

Steffen

White³

et al. 2019

The Lancet

241

184

View full text Add to dashboard Cite

Mass gathering events are associated with major public health challenges. The 2014 Lancet Series on the new discipline of mass gatherings medicine was launched at the World Health Assembly of Ministers of Health in Geneva in May, 2014. The Series covered the planning and surveillance systems used to monitor public health risks, public health threats, and experiences of health-care providers from mass gathering events in 2012 and 2013. This follow-up Review focuses on the main public health issues arising from planned mass gathering events held between 2013 and 2018. We highlight public health and research data on transmission of infectious diseases and antibioticresistant bacteria, mass casualty incidents, and non-communicable diseases, including thermal disorders. In the events discussed in this Review, the combination of a large influx of people, many from countries with outbreakprone infectious diseases, with a high degree of crowd interactions imposed substantial burdens on host countries' health systems. The detection and transmission of antibiotic-resistant bacteria in pilgrims attending the Kumbh Mela and the Hajj raise concern of possible globalisation from mass-gathering religious events. Priorities for further investments and opportunities for research into prevention, surveillance, and management of these public health issues are discussed. Search strategy and selection criteriaWe searched PubMed, Embase, Cochrane Library, and Google Scholar for English language papers that were published from a.zumla@ucl.ac.uk disorders. Priorities for further investments and oppor tunities for research into prevention, surveillance, and management of communicable and noncom municable diseases, thermal disorders, and mass casualty incidents are discussed.

show abstract

Section: The 23rd World Scout Jamboreementioning

confidence: 99%

Section: The 23rd World Scout Jamboreementioning

confidence: 99%

Mass gatherings medicine: public health issues arising from mass gathering religious and sporting events

Memish

Steffen

White³

et al. 2019

The Lancet

241

184

View full text Add to dashboard Cite

show abstract

“…Clinical isolates of N. meningitidis serogroups W (n = 13) and Y (n = 10) collected in Sweden were included in the study ( Table 1). Ten of the NmW isolates belonged to the 2013 strain of cc11, including four isolates connected to the outbreak at the 2015 World Scout Jamboree in Japan (one invasive isolate and three nasopharynx/throat isolates collected from close contacts during the outbreak) [27]. Three invasive isolates belonging to the same linage as the original UK strain were also included (see Additional File 1).…”

Section: Bacterial Isolatesmentioning

confidence: 99%

Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Neisseria meningitidis serogroups W and Y are the most common serogroups causing invasive meningococcal disease in Sweden. The majority of cases are caused by the serogroup W UK 2013 strain of clonal complex (cc) 11, and subtype 1 of the serogroup Y, YI strain of cc23. In this study, virulence factors of several lineages within cc11 and cc23 were investigated in transgenic BALB/c mice expressing human transferrin. Transgenic mice were infected intraperitoneally with serogroup W and Y isolates. Levels of bacteria and the proinflammatory cytokine CXCL1 were determined in blood collected 3 h and 24 h post-infection. Apoptosis was investigated in immune cells from peritoneal washes of infected mice. Adhesion and induction of apoptosis in human epithelial cells were also scored. Results: The levels of bacteraemia, CXCL1, and apoptosis were higher in serogroup W infected mice than in serogroup Y infected mice. Serogroup W isolates also induced higher levels of apoptosis and adhesion in human epithelial cells. No significant differences were observed between different lineages within cc11 and cc23. Conclusions: N. meningitidis Serogroup W displayed a higher virulence in vivo in transgenic mice, compared to serogroup Y. This was reflected by higher bacteremia, proinflammatory activity, and ability to induce apoptosis in mouse immune cells and human epithelial cells.

show abstract

“…Some isolates were from outbreaks where IMD isolates and carriage isolates were linked as described in Table 1 . Outbreak 1 was derived from teenagers associated with an outbreak at a World Scout Jamboree whereof one is IMD and three are carriage isolates [ 32 ], outbreak 2 was derived from an outbreak of invasive meningococcal disease in the French Alps whereof one is IMD and one is a carriage isolate [ 29 ] and outbreak 3 was derived from a local outbreak whereof all three are IMD isolates [ 31 ]. IMD isolates were collected from blood and the linked carriage isolates from nasopharyngeal swabs.…”

Section: Methodsmentioning

confidence: 99%

Diverse proinflammatory response in pharyngeal epithelial cells upon interaction with Neisseria meningitidis carriage and invasive isolates

Persson,

Koivula,

Jacobsson

et al. 2024

BMC Infect Dis

Self Cite

View full text Add to dashboard Cite

Background Invasive meningococcal disease (IMD), including sepsis and meningitis, can develop when Neisseria meningitidis bacteria breach the barrier and gain access to the circulation. While IMD is a rare outcome of bacterial exposure, colonization of the oropharynx is present in approximately 10% of the human population. This asymptomatic carriage can be long or short term, and it is unknown which determining factors regulate bacterial colonization. Despite descriptions of many bacterial virulence factors and recent advances in detailed genetic identification and characterization of bacteria, the factors mediating invasion and disease vs. asymptomatic carriage following bacterial colonization remain unknown. The pharyngeal epithelia play a role in the innate immune defense against pathogens, and the aim of this study was to investigate the proinflammatory response of pharyngeal epithelial cells following meningococcal exposure to describe the potential inflammatory mediation performed during the initial host‒pathogen interaction. Clinically relevant isolates of serogroups B, C, W and Y, derived from patients with meningococcal disease as well as asymptomatic carriers, were included in the study. Results The most potent cellular response with proinflammatory secretion of TNF, IL-6, CXCL8, CCL2, IL-1β and IL-18 was found in response to invasive serogroup B isolates. This potent response pattern was also mirrored by increased bacterial adhesion to cells as well as induced cell death. It was, however, only with serogroup B isolates where the most potent cellular response was toward the IMD isolates. In contrast, the most potent cellular response using serogroup Y isolates was directed toward the carriage isolates rather than the IMD isolates. In addition, by comparing isolates from outbreaks in Sweden (epidemiologically linked and highly genetically similar), we found the most potent proinflammatory response in cells exposed to carriage isolates rather than the IMD isolates. Conclusion Although certain expected correlations between host‒pathogen interactions and cellular proinflammatory responses were found using IMD serogroup B isolates, our data indicate that carriage isolates invoke stronger proinflammatory activation of the epithelial lining than IMD isolates.

show abstract

Neisseria meningitidis carriage in Swedish teenagers associated with the serogroup W outbreak at the World Scout Jamboree, Japan 2015

Cited by 6 publications

References 29 publications

Mass gatherings medicine: public health issues arising from mass gathering religious and sporting events

Mass gatherings medicine: public health issues arising from mass gathering religious and sporting events

Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice

Diverse proinflammatory response in pharyngeal epithelial cells upon interaction with Neisseria meningitidis carriage and invasive isolates

Contact Info

Product

Resources

About