Neisseria subflavaInfections -Bacteriological aspects of two cases-

Meningitis due to a Combination of <b><i>Streptococcus mitis</i></b> and <b><i>Neisseria subflava</i></b>: A Case Report

“…We present a case in which an elderly immunocompromised patient developed meningitis due to a combination of S. mitis and N. subflava, both of which are natural inhabitants of the mucous membranes of the upper respiratory tract and are generally considered to be benign bacteria [ 1 , 2 , 3 , 4 , 5 ]. Meningitis has been reported to be caused by S. mitis or N. subflava alone in cases involving spinal anesthesia, neurosurgical procedures, malignancy, neurological complications of endocarditis, or in newborns [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Older age, the use of immunosuppressants, DM, and dental treatment played important roles in the present case, in which the patient was treated with ceftriaxone because it diffuses more readily into the CSF than other drugs.…”

“…Balkundi et al [ 1 ] reported a fatal case of penicillin-resistant S. mitis -induced meningitis in a 6-year-old child with acute lymphoblastic leukemia. In addition, Chong et al [ 4 ] reported a fatal case of N. subflava -induced endocarditis, meningitis, and septicemia in a healthy 36-year-old male. We have to recognize that S. mitis and N. subflava can be pathogenic and can cause meningitis in patients with risk factors such as older age, on immunosuppressive treatment, DM, and dental treatment.…”

“…Streptococcus mitis is a component of the normal flora of the oropharynx, skin, gastrointestinal system, and genital tract [ 1 , 2 ]. Neisseria subflava is a natural inhabitant of the mucous membranes of the upper respiratory tract [ 3 , 4 , 5 ]. Both species are generally considered to be benign bacteria, and infections of the central nervous system involving these bacteria are very rare.…”

“…Both species are generally considered to be benign bacteria, and infections of the central nervous system involving these bacteria are very rare. In fact, there have only been a few reports about such cases, and they all involved pediatric patients [ 1 , 2 , 3 , 4 , 5 , 6 ]. In addition, there have not been any reports about cases of meningitis involving a combination of S. mitis and N. subflava .…”

Bacteriemia por Neisseria subflava en un recién nacido

“…Es oxidasa positiva y reduce los nitritos pero no los nitratos 15 . Se pueden diferenciar de otras especies por su capacidad de producir pigmento amarillo y de crecer a 22 ºC 13,16,17 . Muchas de las especies saprofíticas exhiben resistencia enzimática a penicilinas mediada por β-lactamasas codificadas por TEM-1 gen tipo bla.…”