<i>Nigella sativa</i>: Phytochemistry, Pharmacology and its Therapeutic Potential

Tiwari, Prashant; Jena, Susmita; Satpathy, Swaroop; Sahu, Pratap Kumar

doi:10.5958/0974-360x.2019.00526.2

Cited by 23 publications

(13 citation statements)

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“…While ethanol extract showed the presence of alkaloids, phenols, tannins, proteins, amino acids, flavonoids, terpenoids, saponins, and steroids (Table 1). The present findings regarding phytochemical analysis of N. sativa are also in corroboration with the work of Tiwari et al [17], who reported N.sativa phytochemistry, pharmacology, and its therapeutic potential. It was observed alkaloids, phenols, flavonoids, glycosides, terpenoids, and steroids are the important phytoconstituents of N. sativa.…”

Section: Resultssupporting

confidence: 93%

Phytoconstituents of Nigella Sativa and Quantitative Densitometric Analysis of its Bioactive Compound Thymoquinone

Khan¹

2022

TIJPH

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Herbal plants are a reservoir of potential phytochemical compounds and the richest bioresource of drugs for traditional systems of medicine, nutraceuticals, food supplements, modern medicines, pharmaceutical intermediates, folk medicines, and chemical entities for synthetic drugs. In the present study we find out phytoconstituents of Nigella sativa and quantitative densitometric analysis of its bioactive compound thymoquinone in the different solvent extracts. It was found that Nigella sativa seeds were extracted with ethanol, methanol, and benzene as solvents. Phytochemical analysis showed the presence of potent bioactive constituents such as alkaloids, phenols, tannins, trepenoid, saponins, and steroids in methanol extract. Benzene extracts have only alkaloids and steroids. While ethanol extract showed the presence of alkaloids, phenols, tannins, proteins, amino acids, flavonoids, terpenoids, saponins, and steroids. The high-performance thin layer chromatographic method (HPTLC) was employed to quantify and densitometrically analyze thymoquinone in methanol, ethanol, and benzene extract of Nigella sativa. The analysis was performed on an aluminum plate with a mobile phase of n-hexane: ethyl acetate: methanol (7:2:1 v/v/v) and a densitometric measurement using a TLC scanner (CAMAG) at 254 nm. The ethanol extract of N. Sativa exhibited single sharp peak of thymoquinone with 0.85 Rf value, the highest area of the band 8137.6, and a total recovery of was 98.08% which is nearly equal to the standard thymoquinone with Rf value (0.85), the highest area of the band 8789.4 and total recovery was obtained 100%. The present research indicated that purified thymoquinone from N. sativa is a potential source for therapeutic application. Keywords: Phytoconstituents, Herbal extract, Essential oil, Quantification, Chromatography.

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Section: Resultssupporting

confidence: 93%

Phytoconstituents of Nigella Sativa and Quantitative Densitometric Analysis of its Bioactive Compound Thymoquinone

Khan¹

2022

TIJPH

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“…It can be found in Southern Europe, North Africa [9], and Asia including Syria, Turkey, Saudi Arabia, Pakistan, and India [10]. The fruit of NS is a capsule-based fruit containing numerous black trigonal seeds [11].…”

Section: Nigella Sativa and Its Bioactive Component In Skin Wound Heamentioning

confidence: 99%

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin

Nordin

Idrus

2020

IJERPH

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Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process.

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“…One example is Nigella sativa, also known as black cumin (in Portuguese), black seed (in English), or kalonji (in Arabic). Nigella seeds, which are the active part of this plant [ 23 , 24 ], present healing properties according to the Hadith (i.e., the sayings of the Prophet). Scientific studies have confirmed the high thymoquinone (TQ) levels, a biologically active substance in the volatile oil extracted from the seeds [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Exploring Muslims’ Health-Related Behaviours in Portugal: Any Impact on Quotidian Community Pharmacy Practice?

et al. 2022

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Muslims are a growing community in European countries. General health habits, including therapy-related behaviours, have been described, though implications to pharmacy practice might vary with the local dominant culture and setting. This exploratory study aimed to describe Muslims’ prevalent health and medication-related practices and possible implications for culturally competent community pharmacy practice. A descriptive cross-sectional survey was administered to a convenient sample of 100 participants at Lisbon Central Mosque, Portugal. Demographics, dietary, Traditional Arabic and Islamic Medicine (TAIM) and religious practices were examined, including health conditions and conventional biomedical treatments. Participant reported ailments (26%) were aligned with prevalent conditions in the general population. Ill participants were significantly associated with TAIM and Islamic dictates (p < 0.05), particularly Zam-Zam water and milk thistle usage. Participants’ orientation to dietary options and Qur’an restrictions were observed regarding forbidden substances in medication, raising issues on medication adherence for some oral dosage forms. TAIM and religious beliefs supplement illness recovery and health improvement instead of replacing conventional healthcare in a religious minority well integrated within the dominant culture. Portuguese community pharmacists should not neglect religious specificities if seamless care is delivered, enhancing professionals’ collaboration skills with multicultural patients.

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Nigella sativa: Phytochemistry, Pharmacology and its Therapeutic Potential

Cited by 23 publications

References 0 publications

Phytoconstituents of Nigella Sativa and Quantitative Densitometric Analysis of its Bioactive Compound Thymoquinone

Phytoconstituents of Nigella Sativa and Quantitative Densitometric Analysis of its Bioactive Compound Thymoquinone

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Exploring Muslims’ Health-Related Behaviours in Portugal: Any Impact on Quotidian Community Pharmacy Practice?

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