<i>Nocardia asteroides</i>–Infected Aneurysm of the Aorta: Case Report and Review of the Literature

Gates, Jonathan D.; Warth, James A.; McGowan, Katherine

doi:10.2310/6670.2006.00025

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Ocular [34][35][36], endovascular [37,38], renal [39], osteoarticular [40], and other localizations have been described in some rare cases in different types of immunosuppressed patients, and even less frequently in patients without immunosuppression. In our series, one previously healthy patient presented a septic arthritis after a traumatic inoculation.…”

Section: Clinical Featuresmentioning

confidence: 99%

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Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

2010

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Nocardiosis is a rare opportunistic disease that affects mainly patients with deficient cell-mediated immunity, such as those with acquired immunodeficiency syndrome (AIDS) or transplant recipients. Pulmonary disease is the most common presentation in immunosuppressed patients and approximately one-third have a disseminated disease. Primary cutaneous nocardiosis is more frequently observed in immunocompetent patients with direct inoculation of the organism through professional exposure. The diagnosis can be challenging, as signs and symptoms are not specific and a high index of clinical of suspicion is necessary. Although gram stain, modified acid-fast stain, and cultures remain as the standard diagnostic tools, novel molecular techniques have changed the taxonomy of these organisms and, in some instances, have facilitated their identification. The disease has a marked tendency to recur and a high morbidity and mortality rate in immunosuppressed patients. Treatment is usually prolonged and an associated antibiotic treatment is preferred for severe disease. Although sulfonamides in combination with other antibiotics are still the treatment of choice, other associations such as imipenem plus amikacin are preferred in some centers. Linezolid is a useful alternative therapeutic agent due to its oral availability and activity against most of the isolates studied. Twenty-eight cases of nocardiosis were diagnosed at our center between January 1989 and April 2009. We report the epidemiologic characteristics of Nocardia spp. observed in our institution and discuss the risk factors, clinical features, diagnosis, and management of the disease.

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Section: Clinical Featuresmentioning

confidence: 99%

“…Thus, each case needs a careful multidisciplinary evaluation by the primary physician, the infectious diseases specialist, and the surgeon. Mycetoma, some ocular infections, and rare cases with other body sites involvement may require surgical treatment [37,[65][66][67][68][69].…”

Section: Treatmentmentioning

confidence: 99%

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

2010

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“…A mycotic aneurysm, related to the previous infectious pulmonary disease due to Streptococcus pneumoniae , may have been a convincing cause for rapid expansion. However, our patient did not exhibit any signs of infectious disease at the second hospital admittance and, furthermore, infected aneurysms of the aorta are commonly the result of septic emboli or contiguous spread from bacterial endocarditis, and are usually caused by Staphylococcus or Salmonella species 9 …”

Section: Discussionmentioning

confidence: 68%

A Rapidly Expanding Descending Thoracic Aortic Aneurysm: An Unusual Complication

et al. 2008

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The rate of enlargement of a descending thoracic aortic aneurysm is usually low, related to initial size and anatomical position. We report a case of an old, diabetic woman, with previous history of ischemic heart disease, admitted for a broncopneumia, in which a small descending thoracic aortic aneurysm was detected by a routine computed tomography (CT) scan. Because of the presence of comorbid condition, especially in the woman with an infectious respiratory disease, a closer follow-up by a 3-month CT scan was programmed. An impressive enlargement of the aneurysm, occurred in the next 2 months, caused patient's asphyxia and subsequent death. In patients with thoracic aortic aneurysm, mostly in females with comorbid condition, a closer CT scan control should be carried out, irrespective of the previous aneurysm size.

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“…The remaining case (Antonovich et al, 2004) was treated with co-trimoxazole alone. Infection of an aortic aneurysm not associated with prosthetic materials has also been reported (Gates et al, 2006).…”

Section: Nocardia Endocarditismentioning

confidence: 96%

Nocardia cyriacigeorgica: a case of endocarditis with disseminated soft-tissue infection

Cargill

Boyd

Weightman

2010

Journal of Medical Microbiology

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Nocardia cyriacigeorgica is a common environmental organism. It has been isolated from clinical samples in Europe, Asia and North America, predominantly from respiratory samples but also from samples from several other sites. We present a case report of an 85-year-old female patient in the UK who was found to have a multi-focal soft-tissue infection from which N. cyriacigeorgica was isolated. She had a background history of chronic obstructive pulmonary disease and corticosteroid use for polymyalgia rheumatica. During the course of her treatment echocardiography showed the presence of a mobile heart mass attached to a valve leaflet, a major Dukes criterion for endocarditis. We suggest that in cases of disseminated Nocardia infection, endocarditis should be tested for, particularly in cases failing to respond to treatment. We also review previous reports of both N. cyriacigeorgica infection, and of endocarditis due to Nocardia species and related genera. We present a case of possible endocarditis associated with disseminated skin and soft-tissue infection caused by N. cyriacigeorgica, and review the reported cases of endocarditis due to Nocardia species and the related genera Rhodococcus, Dietzia, Tsukamurella and Gordonia. Case report An 85-year-old female with a past history of ischaemic heart disease, chronic obstructive pulmonary disease and polymyalgia rheumatica was admitted in March 2008 to a North Yorkshire district hospital following multiple falls Abbreviation: SOP, standard operating procedure.

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Nocardia asteroides–Infected Aneurysm of the Aorta: Case Report and Review of the Literature

Cited by 6 publications

References 16 publications

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

A Rapidly Expanding Descending Thoracic Aortic Aneurysm: An Unusual Complication

Nocardia cyriacigeorgica: a case of endocarditis with disseminated soft-tissue infection

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