NUCOME: A Comprehensive Database of Nucleosome Organizations in Mammalian Genomes

Abstract

Nucleosome organization is involved in many regulatory activities in various organisms. However, studies integrating nucleosome organizations in mammalian genomes are very limited mainly due to the lack of comprehensive data management. Here, we present NUCOME, which is the first database to organize publicly available MNase-seq data resource and manage unified processed datasets covering various cell types in human and mouse. The NUCOME provides standard, qualified and informative nucleosome organization data at the genome scale and at any genomic regions for users’ downstream analyses. NUCOME is freely available at http://compbio.tongji.edu.cn/NUCOME/.