NUP98 Rearrangement in Acute Myelomonocytic Leukemia With t(11;19)(p15;p12): The First Case Report Worldwide

Abnormally Hypersegmented Neutrophilia in Pediatric Acute Myeloid Leukemia Associated With t(2;11)(q31;p15) and NUP98 Rearrangement

“…Intriguingly, >80% of the neutrophils represented markedly hypersegmented nuclei of this case, which is particularly similar to the previous case reported with ~50% hypersegmented neutrophils 8. The 2 cases represent NUP98-HOXD fusion due to the same chromosomal translocation between chromosome 2 and 11, however, a case report on AML-M4 with t(11;19)(p15;p12) and NUP98 fusion indicated no hypersegmented neutrophils 9. Thus, this phenomenon may be associated with the NUP98-HOXD fusion proteins.…”

“…8 The 2 cases represent NUP98-HOXD fusion due to the same chromosomal translocation between chromosome 2 and 11, however, a case report on AML-M4 with t(11;19)(p15; p12) and NUP98 fusion indicated no hypersegmented neutrophils. 9 Thus, this phenomenon may be associated with the NUP98-HOXD fusion proteins. To our knowledge, subpopulations of neutrophils represent different phenotype of maturity, tumor cytotoxicity, and immune suppression.…”