This paper presents the study of power/ground (P/G) supply-induced jitter (PGSIJ) on a cascaded inverter output buffer. The PGSIJ analysis covers the IO buffer transient simulation under P/G supply voltage variation at three process, voltage, and temperature (PVT) corners defined at different working temperatures and distinct P/G DC supply voltages at the pre-driver (i.e., VDD/VSS) and last stage (i.e., VDDQ/VSSQ). Firstly, the induced jitter contributions by the pre-driver, as well as the last, stage are compared and studied. Secondly, the shared and decoupled P/G supply topologies are investigated. The outcomes of these simulation analyses with respect to worst case jitter corners are determined, while highlighting the importance of modeling the pre-driver circuit behavior to include the induced jitter in the input–output buffer information specification (IBIS)-like model. Accordingly, the measured PGSIJ depends on the corners to be analyzed and, therefore, the designer needs to explore the worst-case corner for the driver’s technology node and the most supply voltage noise affecting the jitter output for signal and power integrity (SiPI) simulations. Finally, the jitter transfer function sensitivity to the amplitude and frequency/phase variations of the separate and combined impacts of the pre-driver and last stage are explored, while discussing the superposition of the power supply induced jitter (PSIJ) induced by both the driver’s IO stages under small signal and large signal supply voltage variations. The linear superposition of the separate PSIJ effects by the pre-driver and last stage depends on the amplitude of the variation of the supply voltage that can drive the transistor to their nonlinear working regions.