<i>Otostegia persica</i>. as a Source of Natural Antioxidants

Yassa, Narguess; Sharififar, Fariba; Shafiee, Abbas

doi:10.1080/13880200590903336

Cited by 30 publications

(17 citation statements)

References 18 publications

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“…In this study, three geniuses of Labiatae revealed very significant inhibitory effects on a-glucosidase (Figures 1-3), and it seems that they enjoyed strong antidiabetic activities. Hence, with due attention to the antidiabetic compounds in the natural products (Arif et al 2014;Benalla et al 2010), these three plant extracts may contain antidiabetic compounds such as polyphenols, triterpenes, phytosterols, flavonoids, flavanones, genine derivatives, and anthocyanin (Ali et al 2000;Lu & Foo 2002;Yassa et al 2005;Sadeghi & Alizadeh 2013;Sajed et al 2013;Sadeghi et al 2014;Zarshenas & Krenn 2015).…”

Section: Discussionmentioning

confidence: 99%

Kinetics of α-glucosidase inhibition by different fractions of three species of Labiatae extracts: a new diabetes treatment model

Rouzbehan

Moein

Homaei

et al. 2017

Pharmaceutical Biology

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Context: Glucosidases are a group of enzymes playing crucial roles in digestion of carbohydrates. Glucosidase inhibitors can reduce carbohydrate digestion rate and have the potential to prevent development of type 2 diabetes. The Labiatae is one of the largest plant families grown globally and many studies that have isolated new pharmaceutical compounds. In folk medicine, some of Labiatae plants such as Zataria multiflora Boiss, Salvia mirzayanii Rech. F. & Esfand, and Otostegia persica Boiss are consumed for the treatment of diabetes. Objectives: This study investigates the inhibitory effects of different fractions of three mentioned species extracts on a-glucosidase. Materials and methods: Ethanol extracts of these plants leaves were fractionated using petroleum ether, chloroform, ethyl acetate, and n-butanol solutions. The duration of this study was 12 months. To measure enzyme inhibition, 5 lL of the enzyme, 20 lL of substrate and samples were used and for evaluation mode of inhibition, constant amounts of a-glucosidase were incubated with rising concentrations of substrate (PNPG). Results:The results revealed that the ethyl acetate fraction of Zataria multiflora (IC 50 ¼ 0.35 ± 0.01 mg/mL) and petroleum ether fraction of Salvia mirzayanii (IC 50 ¼ 0.4 ± 0.11 mg/mL) were the most potent inhibitors of a-glucosidase in comparison with the other samples and acarbose as the standard (IC 50 ¼ 7 ± 0.19 mg/ mL). All of the samples exhibited noncompetitive-uncompetitive inhibition. Discussion and conclusion: It can be inferred from this study that a-glucosidase inhibitory potential of the studied extracts may be a marker of antidiabetic potential of these extracts. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Kinetics of α-glucosidase inhibition by different fractions of three species of Labiatae extracts: a new diabetes treatment model

Rouzbehan

Moein

Homaei

et al. 2017

Pharmaceutical Biology

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“…In continuation of our research program and in an effort to develop a novel radical scavenger and potential antioxidant [11][12][13], we synthesized a series of coumarin derivatives containing 2-methylbenzothiazoline motif and evaluated their radical scavenging properties. Thus, we report here, the synthesis and DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Free Radical Scavenging Activity of Coumarin Derivatives Containing a 2‐Methylbenzothiazoline Motif

Khoobi

Emami

Dehghan

et al. 2011

Archiv der Pharmazie

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Coumarin and benzothiazole scaffolds can be found in a number of natural or synthetic antioxidants. In an effort to develop a novel radical scavenger and potential antioxidant, a series of coumarin derivatives containing 2-methylbenzothiazoline motif and related compounds was synthesized and evaluated for their DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS(•+) (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radicals scavenging activities. Among them, 7-hydroxy-3-(2-methyl-2,3-dihydrobenzo[d]thiazol-2-yl)-2H-chromen-2-one (3e) has shown a significant free radical scavenging activity. From the structure-activity point of view, it was found that phenolic coumarin ring and benzothiazoline moiety in target compounds may contribute to the scavenging activity against free radicals.

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“…As a part of our ongoing program to design novel antioxidant candidate [13,14], herein, we report the synthe-sis and biological screening of a number of benzimidazolo [2,1-b]benzo[e]thiazepin-5(10H)-ones.…”

Section: Introductionmentioning

confidence: 99%

Syntheses and Biological Activities of Benzimidazolo[2,1‐b] benzo[e]thiazepin‐5(10H)‐ones

Rastkari

Abdollahi

Ahmadkhaniha

et al. 2007

Archiv der Pharmazie

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Substituted benzimidazolo[2,1-b]benzo[e]thiazepin-5(10H)-one derivatives were prepared in moderate to good yield by reaction of mercapto benzimidazole derivatives with 2-chloromethylbenzoyl chloride as a coupling component. Their structures were confirmed by elemental analysis, IR, NMR, and MS. Their antioxidant properties were evaluated by several methods: scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, reducing power assay, and inhibition of lipid peroxidation. In DPPH assay, 3h exhibited an activity stronger than trolox. In the reducing power assay and inhibition of lipid peroxidation, compound 3a was more active than 3h and similar to trolox. The antidiabetic effect was also determined, and the antidiabetic activities were correlated with their antioxidant properties, compound 3a was the most active compound in the in-vivo experiments.

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Otostegia persica. as a Source of Natural Antioxidants

Cited by 30 publications

References 18 publications

Kinetics of α-glucosidase inhibition by different fractions of three species of Labiatae extracts: a new diabetes treatment model

Kinetics of α-glucosidase inhibition by different fractions of three species of Labiatae extracts: a new diabetes treatment model

Synthesis and Free Radical Scavenging Activity of Coumarin Derivatives Containing a 2‐Methylbenzothiazoline Motif

Syntheses and Biological Activities of Benzimidazolo[2,1‐b] benzo[e]thiazepin‐5(10H)‐ones

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