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            ‐Tolylsulfonylmethyl Isocyanide

Hoogenboom, Bernard E.; Oldenziel, O. H.; Leusen, A. M. Van

doi:10.1002/0471264180.os057.27

Cited by 13 publications

(14 citation statements)

References 16 publications

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“…When the radial distribution function g(r) is calculated from the reconstructed coordinates (8912 particles), a good agreement with the FCC structure is found (see Figure 3e). There is however a double peak at r/d ≈ 1, which is absent in close packed crystals grown in bulk or by gravity 49 . From the ratio of the r/d values of the two peaks in Figure 3e it follows that the difference is close to 4%.…”

Section: Fib-sem Tomography Of a Colloidal Crystalmentioning

confidence: 95%

Bridging the gap: 3D real-space characterization of colloidal assemblies via FIB-SEM tomography

et al. 2019

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† Electronic Supplementary Information (ESI) available: Movies S1-12 show the transmission electron tomography, FIB-SEM tomography and confocal microscopy data stacks and 3D reconstructions. Figures S1-4 give additional information on our image processing methods and show extra electron tomography data. SeeInsight in the structure of nanoparticle assemblies up to a single particle level is key to understand the collective properties of these assemblies, which critically depend on the individual particle positions and orientations. However, the characterization of large, micron sized assemblies containing small, 10-500 nanometer, sized colloids is highly challenging and cannot easily be done with the conventional light, electron or X-ray microscopy techniques. Here, we demonstrate that focused ion beam-scanning electron microscopy (FIB-SEM) tomography in combination with image processing enables quantitative real-space studies of ordered and disordered particle assemblies too large for conventional transmission electron tomography, containing particles too small for confocal microscopy. First, we demonstrate the high resolution structural analysis of spherical nanoparticle assemblies, containing small anisotropic gold nanoparticles. Herein, FIB-SEM tomography allows the characterization of assembly dimensions which are inaccessible to conventional transmission electron microscopy. Next, we show that FIB-SEM tomography is capable of characterizing much larger ordered and disordered assemblies containing silica colloids with a diameter close to the resolution limit of confocal microscopes. We determined both the position and the orientation of each individual (nano)particle in the assemblies by using recently developed particle tracking routines. Such high precision structural information is essential in the understanding and design of the collective properties of new nanoparticle based materials and processes. arXiv:1903.09989v1 [cond-mat.soft]

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Section: Fib-sem Tomography Of a Colloidal Crystalmentioning

confidence: 95%

Bridging the gap: 3D real-space characterization of colloidal assemblies via FIB-SEM tomography

et al. 2019

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“…Previous studies have addressed the crystallization of hard spheres in gravity by confining the system with flat walls [35][36][37][38][39][40]. In this case the high nucleation rates were due to heterogeneous nucleation on the walls.…”

Section: Static Propertiesmentioning

confidence: 99%

The interplay of sedimentation and crystallization in hard-sphere suspensions

et al. 2013

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We study crystal nucleation under the influence of sedimentation in a model of colloidal hard spheres via Brownian Dynamics simulations. We introduce two external fields acting on the colloidal fluid: a uniform gravitational field (body force), and a surface field imposed by pinning a layer of equilibrium particles (rough wall). We show that crystal nucleation is suppressed in proximity of the wall due to the slowing down of the dynamics, and that the spatial range of this effect is governed by the static length scale of bond orientational order. For distances from the wall larger than this length scale, the nucleation rate is greatly enhanced by the process of sedimentation, since it leads to a higher volume fraction, or a higher degree of supercooling, near the bottom. The nucleation stage is similar to the homogeneous case, with nuclei being on average spherical and having crystalline planes randomly oriented in space. The growth stage is instead greatly affected by the symmetry breaking introduced by the gravitation field, with a slowing down of the attachment rate due to density gradients, which in turn cause nuclei to grow faster laterally. Our findings suggest that the increase of crystal nucleation in higher density regions might be the cause of the large discrepancy in the crystal nucleation rate of hard spheres between experiments and simulations, on noting that the gravitational effects in previous experiments are not negligible. PACS numbers:

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“…The combined organic extracts were washed with water, dried (Na 2 SO 4 ) and evaporated to afford 2adamantanecarbonitrile 18 (10.7 g, 96%); mp 177ºC (hexane); this product had the same spectral characteristics and physical constants as those mentioned in the literature (Hoogenboom et al, 1988). A vigorous reaction and gas formation was observed during the addition and the mixture was left to reach room temperature.…”

Section: -Tricyclo[3311 37 ]Decanecarbonitrile (18)mentioning

confidence: 83%

Are the 2-Isomers of the Drug Rimantadine Active Anti-Influenza a Agents?

Zoidis

Kolocouris

Foscolos

et al. 2003

Antivir Chem Chemother

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There is a lack of information in the medical chemistry literature concerning the anti-influenza A activity of the drug rimantadine's 2-isomer (2-rimantadine). We now present results showing that, although 2-adamantanamine (2-amantadine) 3 is only moderately active, some 2-rimantadine analogues are effective anti-influenza A virus agents in vitro. The 2-rimantadine analogues and their spirocyclobutane and spirocyclopentane congeners were synthesized through interesting routes. The 2-rimantadine analogues were 2-4 times more potent than rimantadine 2 against influenza virus A H2N2 strain; their spirocyclobutane congeners proved equally active to rimantadine 2. Two compounds exhibited a similar activity and one of the compounds was was fourfold more potent than rimantadine 2 against H3N2 strain.

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p ‐Tolylsulfonylmethyl Isocyanide

Abstract: p ‐Tolylsulfonylmethyl isocyanide intermediate: N ‐( p ‐tolylsulfonylmethyl)formamide solvent: One liter of petroleum ether product: p ‐tolylsulfonylmethyl isocyanide

Cited by 13 publications

References 16 publications

Bridging the gap: 3D real-space characterization of colloidal assemblies via FIB-SEM tomography

Bridging the gap: 3D real-space characterization of colloidal assemblies via FIB-SEM tomography

The interplay of sedimentation and crystallization in hard-sphere suspensions

Are the 2-Isomers of the Drug Rimantadine Active Anti-Influenza a Agents?

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