<i>Paecilomyces lilacinus</i> cutaneous infection associated with peripherally inserted central catheter insertion

Wl, Lin; Cs, Chiu

doi:10.1111/j.1468-3083.2008.02619.x

Cited by 6 publications

(2 citation statements)

References 8 publications

(9 reference statements)

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“…4 Through literature review we found a report about cutaneous infection of Purpureocillium lilacinus associated with peripheral insertion of a central catheter. 5 Here we report a case of Purpureocillium lilacinus infection at the venipuncture site on the back of the right hand due to chronic obstructive pulmonary disease (COPD).…”

Section: Introductionmentioning

confidence: 99%

Cutaneous hyphomycosis Caused by Purpureocillium lilacinus Infection Associated with Superficial Venipuncture: A Case Report

Zhou,

Qi,

Guo

et al. 2023

CCID

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Cutaneous hyphomycosis caused by Purpureocillium lilacinus is a relatively uncommon event in patients, but there has been a gradual increase in reported cases. A 71-year-old female patient was hospitalized in May 2022 due to an acute episode of chronic obstructive pulmonary disease and received glucocorticoid infusion. The skin around the puncture point on the back of her right hand showed erythema, nodules, scabs, and pus discharge, which gradually worsened. Fungal examination revealed the presence of hyphae, while treatment with terbinafine was ineffective. After fungal culture, pathological analysis, and molecular biology identification techniques, this case was diagnosed as cutaneous and subcutaneous infections caused by Purpureocillium lilacinus . After 2 weeks of treatment with itraconazole, the patient recovered. Patients on long-term hormone preparations who undergo superficial venipuncture should be aware of the risk of skin damage and potential infection by Purpureocillium lilacinus . Prompt fungal culture, histopathological analysis, and molecular identification are crucial for accurate diagnosis. Antifungal susceptibility testing should be considered for effective treatment.

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Section: Introductionmentioning

confidence: 99%

Cutaneous hyphomycosis Caused by Purpureocillium lilacinus Infection Associated with Superficial Venipuncture: A Case Report

Zhou,

Qi,

Guo

et al. 2023

CCID

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“…In patients with cutaneous forms of hyalohyphomycosis caused by P. lilacinum , several authors describe the presence of mixed inflammatory infiltrates in the lesions, composed of macrophages, neutrophils, and dendritic cells (DCs) ( Gutierrez-Rodero et al, 1999 ; Lin et al, 2008 ; Huang et al, 2011 ). Since cutaneous infections constitute the majority of cases of fungal hyalohyphomycosis, it is necessary to emphasize the importance of these cells in the phagocytosis and presentation of antigens and, consequently, in the efficiency of the adaptive response ( Antachopoulos and Roilides, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Skin Immune Response of Immunocompetent and Immunosuppressed C57BL/6 Mice After Experimental Subcutaneous Infection Caused by Purpureocillium lilacinum

et al. 2021

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Hyalohyphomycosis is a fungal infection characterized by the presence of a hyaline mycelium in the host. It is caused by several agents, such as Purpureocillium lilacinum. Our study aimed to evaluate some cell subsets and inflammatory markers involved in the in situ immune response to subcutaneous hyalohyphomycosis by P. lilacinum in C57BL/6 murine models. The fungal isolate was inoculated in mice randomly distributed in immunocompetent/infected (CI) and immunosuppressed/infected (SI) groups. Mice were evaluated on days 1, 3, 5, and 7 after inoculation. Histopathological studies showed several lesions in the site of infection as well as the formation of multifocal and mixed inflammatory infiltrates, which differed between the CI and SI groups. This analysis also revealed conidia and hypha-like structures in subcutaneous tissues of mice of both groups. The immunohistochemical analysis showed lower percentages of macrophages and neutrophils in the SI group compared to those in the CI group. Moreover, the intensity of interleukin (IL)-1β and nitric oxide synthase 2 production by cells of immunosuppressed mice was discreet, compared to immunocompetent mice that ranged from moderate to intense over time. The quantitative interference of dexamethasone in the response to the fungus was also demonstrated. We concluded that our results can be useful not only to broaden the knowledge on P. lilacinum but also, based on this host–parasite relationship, to contribute to the understanding of the mechanisms of infection.

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Hyalohyphomycosis

Grossman

Fox

Kovarik

et al. 2011

Cutaneous Manifestations of Infection in the Immunocompromised Host

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Paecilomyces lilacinus cutaneous infection associated with peripherally inserted central catheter insertion

Cited by 6 publications

References 8 publications

Cutaneous hyphomycosis Caused by Purpureocillium lilacinus Infection Associated with Superficial Venipuncture: A Case Report

Cutaneous hyphomycosis Caused by Purpureocillium lilacinus Infection Associated with Superficial Venipuncture: A Case Report

Skin Immune Response of Immunocompetent and Immunosuppressed C57BL/6 Mice After Experimental Subcutaneous Infection Caused by Purpureocillium lilacinum

Hyalohyphomycosis

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