<i>Paecilomyces lilacinus</i>Vaginitis in an Immunocompetent Patient

Carey, Jeanne; D'Amico, R; Sutton, Deanna A.; Rinaldi, Michael G.

doi:10.3201/eid0909.020654

Cited by 33 publications

(21 citation statements)

References 14 publications

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“…The incidence of infections in immunocompetent hosts is also increasing. [2] Paecilomyces lilacinus has been reported to cause cutaneous infections including catheter-related fungemia, sinusitis, [3] dermatitis, and disseminated disease secondary to application of a contaminated skin lotion in immunocompromised patients. [4] P. lilacinus and P. variotii are the two species most frequently associated with human disease.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Paecilomyces lilacinus infections in immunocompromised and immunocompetent patients

Bassiri-Jahromi¹

2014

Indian J Dermatol Venereol Leprol

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Paecilomyces is a genus of saprophytic fungus that has been associated, in rare instances, with human disease. We report two cases in which Paecilomyces lilacinus was isolated from cutaneous and subcutaneous lesions in an immunocompromised and an immunocompetent host. The first case was a subcutaneous infection due to P. lilacinus in a patient with a renal transplant and diabetes mellitus. The second case was an immunocompetent young woman who developed a cutaneous infection, with no identified predisposing factors. A biopsy from each patient provided an initial diagnosis of fungal elements in the tissues under examination and multiple positive fungal cultures were obtained from the tissue biopsy samples. Both microscopic and macroscopic examinations of the biopsy revealed the presence of P. lilacinus. Each of the two cases was successfully treated with oral ketoconazole (200 mg/day) and itraconazole. We also review previously reported cases in which the clinical history and response to therapy were noted.

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Section: Introductionmentioning

confidence: 99%

Cutaneous Paecilomyces lilacinus infections in immunocompromised and immunocompetent patients

Bassiri-Jahromi¹

2014

Indian J Dermatol Venereol Leprol

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“…5 However, certain fungi causing vaginitis also have been encountered in immunocompetent hosts. 6,7 Fruiting bodies are very important in identification of a particular fungus and its species, depending on the length and width of conidiophores, shape of vesicles and the chains of conidia. In the present case, all of the above factors strongly suggested that the fungus present in the Pap smear was a contaminant and the probable species was Aspergillus fumigatus.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Presentation of Aspergillus Species in a Routine Cervicovaginal Pap Smear

Chandra

Gaur²,

Harsh³

et al. 2009

Acta Cytologica

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“…This species can colonize materials such as catheters and plastic implants and can contaminate antiseptic creams and lotions, causing infections in immunocompetent and immunocompromised patients (Castro et al ., 1990; Orth et al ., 1996; Itin et al ., 1998). The prevalence of P. lilacinus in patients has increased recently (Carey et al ., 2003; Rosmaninho et al ., 2010). A review of 119 infections caused by P. lilacinus after 1964 showed that the most frequent manifestation is keratitis, but other sites of the body were also affected (Pastor & Guarro, 2006).…”

Section: Introductionmentioning

confidence: 99%

Purpureocillium, a new genus for the medically important Paecilomyces lilacinus

Luangsa‐ard

Houbraken

Doorn

et al. 2011

FEMS Microbiology Letters

283

172

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Paecilomyces lilacinus was described more than a century ago and is a commonly occurring fungus in soil. However, in the last decade this fungus has been increasingly found as the causal agent of infections in man and other vertebrates. Most cases of disease are described from patients with compromised immune systems or intraocular lens implants. In this study, we compared clinical isolates with strains isolated from soil, insects and nematodes using 18S rRNA gene, internal transcribed spacer (ITS) and partial translation elongation factor 1-α (TEF) sequences. Our data show that P. lilacinus is not related to Paecilomyces, represented by the well-known thermophilic and often pathogenic Paecilomyces variotii. The new genus name Purpureocillium is proposed for P. lilacinus and the new combination Purpureocillium lilacinum is made here. Furthermore, the examined Purpureocillium lilacinum isolated grouped in two clades based on ITS and partial TEF sequences. The ITS and TEF sequences of the Purpureocillium lilacinum isolates used for biocontrol of nematode pests are identical to those causing infections in (immunocompromised) humans. The use of high concentrations of Purpureocillium lilacinum spores for biocontrol poses a health risk in immunocompromised humans and more research is needed to determine the pathogenicity factors of Purpureocillium lilacinum.

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Paecilomyces lilacinusVaginitis in an Immunocompetent Patient

Abstract: Paecilomyces lilacinus, an environmental mold found in soil and vegetation, rarely causes human infection. We report the first case of P. lilacinus isolated from a vaginal culture in a patient with vaginitis.

Cited by 33 publications

References 14 publications

Cutaneous Paecilomyces lilacinus infections in immunocompromised and immunocompetent patients

Cutaneous Paecilomyces lilacinus infections in immunocompromised and immunocompetent patients

An Unusual Presentation of Aspergillus Species in a Routine Cervicovaginal Pap Smear

Purpureocillium, a new genus for the medically important Paecilomyces lilacinus

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