<i>Paeniclostridium sordellii</i>–associated peripartum metritis in goats

González-Astudillo, Viviana; Asin-Ros, Javier; Moore, Janet; Uzal, Francisco A.; Navarro, Mauricio A.

doi:10.1177/03009858221133506

Cited by 3 publications

(6 citation statements)

References 26 publications

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“…5,30 A series of 9 cases of postpartum metritis has been reported in does in association with P. sordellii infection. 13 In 9 of our cases, we isolated Escherichia coli (8 of 9), C. perfringens (7 of 9), and P. sordellii (4 of 9); C. perfringens, C. septicum, C. chauvoei, and C. novyi were detected in some of the cases by IHC. These results indicate that our metritis cases were polymicrobial.…”

Section: Discussionmentioning

confidence: 84%

“…5,30 A series of 9 cases of postpartum metritis has been reported in does in association with P. sordellii infection. 13…”

Section: Discussionmentioning

confidence: 99%

“…Increased susceptibility of the uterus to infections might be predisposed by mineral deficiencies. 13 We did not explore this possibility, and the source of infection and the route of transmission were not determined, but we hypothesize that micro-lacerations associated with the birth process could have favored the entry of clostridia.…”

Section: Discussionmentioning

confidence: 99%

“…5,30 A series of 9 cases of periparturient metritis associated with Paeniclostridium sordellii has been reported in goats. 13…”

mentioning

confidence: 99%

“…5,30 A series of 9 cases of periparturient metritis associated with Paeniclostridium sordellii has been reported in goats. 13 Clostridia are mostly gram-positive, sporulating anaerobic rods that are associated with several major diseases in goats. C. perfringens type A, C. septicum, and C. novyi are associated with gas gangrene, 9,11,14 C. perfringens types B and C with hemorrhagic enteritis, 10,29 C. perfringens type D with enterotoxaemia, 17,28 and C. novyi with necrotic hepatitis.…”

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confidence: 99%

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Postpartum clostridial gangrenous metritis in 12 dairy goats in France

et al. 2023

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Clostridial infections in goats have been associated frequently with enteric diseases or gas gangrene but very rarely with the reproductive system. We describe here 12 cases of fatal postpartum gangrenous metritis in does associated with infection by several clostridial species. Clinically, these cases were characterized by rapid onset of hyperthermia followed by death after kidding. On postmortem examination, the uteri appeared to be necrotic and were hemorrhagic and edematous. Microscopically, the uteri had diffuse coagulative necrosis, edema, hemorrhage, and fibrinous thrombi with intralesional gram-positive rods. Clostridium perfringens was isolated from 7 of 9 uterine samples cultured, and C. perfringens, C. septicum, C. novyi, or C. chauvoei were demonstrated by immunohistochemistry (IHC) in the 5 cases examined. IHC for Paeniclostridium sordellii was negative in all 5 cases. PCR performed on 3 of the C. perfringens isolates was positive for alpha toxin and perfringolysin, identifying these isolates as type A. Clostridial infection should be considered in cases of postpartum gangrenous metritis of does.

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Section: Discussionmentioning

confidence: 84%

“…5,30 A series of 9 cases of postpartum metritis has been reported in does in association with P. sordellii infection. 13…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…5,30 A series of 9 cases of periparturient metritis associated with Paeniclostridium sordellii has been reported in goats. 13…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Postpartum clostridial gangrenous metritis in 12 dairy goats in France

et al. 2023

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Gut bacterial composition shows sex-specific shifts during breeding season in ex situ managed black-footed ferrets

DeCandia,

Adeduro,

Thacher

et al. 2023

Journal of Heredity

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The gut microbiome of mammals engages in a dynamic relationship with the body and contributes to numerous physiological processes integral to overall health. Understanding the factors shaping animal-associated bacterial communities is therefore paramount to the maintenance and management in ex situ wildlife populations. Here, we characterized the gut microbiome of 48 endangered black-footed ferrets (Mustela nigripes) housed at Smithsonian’s National Zoo and Conservation Biology Institute (Front Royal, Virginia, USA). We collected longitudinal fecal samples from males and females across two distinct reproductive seasons to consider the role of host sex and reproductive physiology in shaping bacterial communities, as measured using 16S rRNA amplicon sequencing. Within each sex, gut microbial composition differed between breeding and non-breeding seasons, with five bacterial taxa emerging as differentially abundant. Between sexes, female and male microbiomes were similar during non-breeding season but significantly different during breeding season, which may result from sex-specific physiological changes associated with breeding. Finally, we found low overall diversity consistent with other mammalian carnivores alongside high relative abundances of potentially pathogenic microbes such as Clostridium, Escherichia, Paeniclostridium, and (to a lesser degree) Enterococcus – all of which have been associated with gastrointestinal or reproductive distress in mammalian hosts, including black-footed ferrets. We recommend further study of these microbes and possible therapeutic interventions to promote more balanced microbial communities. These results have important implications for ex situ management practices that can improve the gut microbial health and long-term viability of black-footed ferrets.

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Populational genomic insights of Paraclostridium bifermentans as an emerging human pathogen

Cai,

Peng,

Yang

et al. 2023

Front. Microbiol.

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Paraclostridium bifermentans (P.b) is an emerging human pathogen that is phylogenomically close to Paeniclostridium sordellii (P.s), while their populational genomic features and virulence capacity remain understudied. Here, we performed comparative genomic analyses of P.b and compared their pan-genomic features and virulence coding profiles to those of P.s. Our results revealed that P.b has a more plastic pangenome, a larger genome size, and a higher GC content than P.s. Interestingly, the P.b and P.s share similar core-genomic functions, but P.b encodes more functions in nutrient metabolism and energy conversion and fewer functions in host defense in their accessory-genomes. The P.b may initiate extracellular infection processes similar to those of P.s and Clostridium perfringens by encoding three toxin homologs (i.e., microbial collagenase, thiol-activated cytolysin, phospholipase C, which are involved in extracellular matrices degradation and membrane damaging) in their core-genomes. However, P.b is less toxic than the P.s by encoding fewer secretion toxins in the core-genome and fewer lethal toxins in the accessory-genome. Notably, P.b carries more toxins genes in their accessory-genomes, particularly those of plasmid origin. Moreover, three within-species and highly conserved plasmid groups, encoding virulence, gene acquisition, and adaptation, were carried by 25–33% of P.b strains and clustered by isolation source rather than geography. This study characterized the pan-genomic virulence features of P.b for the first time, and revealed that P. bifermentans is an emerging pathogen that can threaten human health in many aspects, emphasizing the importance of phenotypic and genomic characterizations of in situ clinical isolates.

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Paeniclostridium sordellii–associated peripartum metritis in goats

Cited by 3 publications

References 26 publications

Postpartum clostridial gangrenous metritis in 12 dairy goats in France

Postpartum clostridial gangrenous metritis in 12 dairy goats in France

Gut bacterial composition shows sex-specific shifts during breeding season in ex situ managed black-footed ferrets

Populational genomic insights of Paraclostridium bifermentans as an emerging human pathogen

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