Panax notoginseng saponins attenuate acute lung injury induced by intestinal ischaemia/reperfusion in rats

Abstract

Administration of PNS before reperfusion injury alleviates acute lung injury induced by II/R, and this is attributable to the antioxidant and anti-inflammatory effects of PNS.

Anti-inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats

“…In a previous study, we showed that PNS administration decreased bacterial translocation and reduced pulmonary parenchymal damage, following II/R in rats. Furthermore, PNS was observed to reduce the activity of oxidative enzymes, the levels of MDA and nitric oxide, the activity of inducible nitric oxide synthase in the lung tissue and the levels of pro-inflammatory cytokines in the plasma (22).…”

“…Previous clinical investigations have revealed a positive correlation between mortality and levels of circulating TNF-α, IL-1β, IL-6 and IL-8 in ALI (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). In the present study, the reduction in inflammatory cytokine levels observed in the plasma of ALI rats following PNS treatment may have contributed to a reduction in leukocyte adhesion and infiltration.…”

“…It has been reported that PNS may protect against cerebral ischemia and exert beneficial effects on the cardiovascular system, as well as possess hemostatic, antioxidant and estrogen-like activities (19)(20)(21). We previously demonstrated that PNS (100 mg/kg) treatment was capable Anti-inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats of alleviating intestinal ischemia/reperfusion (II/R)-induced ALI in rats and that it significantly reduced oxidant enzyme activity, levels of malondialdehyde (MDA) and nitric oxide, the activity of inducible nitric oxide synthase in lung tissue and pro-inflammatory cytokine levels in the plasma (22). The present study investigated the protective effects of PNS on ALI induced in a rat model.…”

“…We previously reported that PNS treatment (100 mg/kg) was capable of alleviating II/R-induced ALI in rats and significantly reduced the activity of oxidant enzymes and inducible nitric oxide synthase in the lung, as well as the levels of MDA and nitric oxide, and pro-inflammatory cytokines in the plasma (22).…”

Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression

“…The PNS dose (100 mg/kg) in vivo was selected based on the previous studies (Rong et al, 2009;Yang et al, 2010;Zhang et al, 2008) with 100 mg/kg iv. in rats, 200 mg/kg ip.…”