<i>Papio</i>spp. Colon microbiome and its link to obesity in pregnancy

Li, Xuanji; Rensing, Christopher; Taylor, William L.; Costelle, Caitlin; Brejnrod, Asker; Ferry, Robert J.; Higgins, Paul; Folli, Franco; Kottapalli, Kameswara Rao; Hubbard, Gene B.; Dick, Edward J.; Yooseph, Shibu; Nelson, Karen E.; Schlabritz‐Loutsevitch, Natalia

doi:10.1111/jmp.12366

Cited by 4 publications

(3 citation statements)

References 76 publications

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“…Based on this evidence, obesity during pregnancy can lead to a change in bacterial phyla not observed in non-obese pregnancies. Such microbial shifts are also observed among animal models including rodents [65,[74][75][76][77]. Various This was confirmed when microbiota from lean donors infused to recipients with metabolic syndrome (BMI > 30 kg/m 2 and fasting plasma glucose > 5.6 mmol/L) restored insulin sensitivity and increased butyrate-producing intestinal bacteria, exerting immunomodulatory and antiinflammatory properties [80].…”

Section: Obesity and The Maternal Gut Microbiota During Pregnancymentioning

confidence: 79%

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing

Rubini

Schenkelaars

Rousian

et al. 2022

American Journal of Obstetrics and Gynecology

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Section: Obesity and The Maternal Gut Microbiota During Pregnancymentioning

confidence: 79%

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing

Rubini

Schenkelaars

Rousian

et al. 2022

American Journal of Obstetrics and Gynecology

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“…Moreover, even the typical gut microbiome of a monkey can be experimentally modified by increasing the fat or fiber content of the food [ 45 ]. Of relevance to the current analysis of pregnancy-related changes, it has been shown that a high-fat diet can impact the gut microbiomes of pregnant monkeys, which in turn can influence the bacteria transferred from the parturient female to her infant after birth [ 88 , 89 ]. Further, the gut microbiome of pregnant monkeys can be differentially affected by whether they become obese when consuming a high fat diet.…”

Section: Discussionmentioning

confidence: 99%

Significant Microbial Changes Are Evident in the Reproductive Tract of Pregnant Rhesus Monkeys at Mid-Gestation but Their Gut Microbiome Does Not Shift until Late Gestation

et al. 2023

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Vaginal and rectal specimens were obtained from cycling, pregnant, and nursing rhesus monkeys to assess pregnancy-related changes in the commensal bacteria in their reproductive and intestinal tracts. Using 16S rRNA gene amplicon sequencing, significant differences were found only in the vagina at mid-gestation, not in the hindgut. To verify the apparent stability in gut bacterial composition at mid-gestation, the experiment was repeated with additional monkeys, and similar results were found with both 16S rRNA gene amplicon and metagenomic sequencing. A follow-up study investigated if bacterial changes in the hindgut might occur later in pregnancy. Gravid females were assessed closer to term and compared to nonpregnant females. By late pregnancy, significant differences in bacterial composition, including an increased abundance of 4 species of Lactobacillus and Bifidobacterium adolescentis, were detected, but without a shift in the overall community structure. Progesterone levels were assessed as a possible hormone mediator of bacterial change. The relative abundance of only some taxa (e.g., Bifidobacteriaceae) were specifically associated with progesterone. In summary, pregnancy changes the microbial profiles in monkeys, but the bacterial diversity in their lower reproductive tract is different from women, and the composition of their intestinal symbionts remains stable until late gestation when several Firmicutes become more prominent.

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“…Prevotellaceae are the dominant species with the most significant changes in the PC group. Prevotellaceae was common in the intestinal tract of healthy children (Pulikkan et al, 2018), it has also been shown to be associated with obesity (Li et al, 2018) and up-regulate three genes associated with cervical cancer (Lam et al, 2018). It was concluded that LM has a better regulation effect on Bacteroides, while HM has a more significant effect on Ruminococcaceae.…”

Section: Screening Of Key Microbial Speciesmentioning

confidence: 99%

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Supplemental Information 8: Figure 6 LDA Analysis

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Hepatocellular carcinoma (HCC) is a kind of cancer with high incidence and often accompanied by intestinal flora imbalance. Many studies have shown that probiotics such as anthocyanins can regulate gut microbiome and improve disease. This study was designed to evaluate the influence of malvidin-3-galactoside (M3G), a blueberry ingredient with several beneficial properties, on gut microorganisms of liver cancer (LC) mice. LC mice were fed M3G diets (LM, 40 mg/kg; HM, 80 mg/kg) or 5-fluorouracil (PC, 20 mg/kg) for three weeks. High-throughput sequencing using the MiSeq platform coupled with freely-available computational tools adopt 16SrRNA and metagenome analyses. There was a greater abundance of Verrucomicrobiaceae (p < 0.05) and Ruminococcus (p < 0.05) in mice in the HM group than in those in the LM group. Antiinflammatory bacteria such as Akkermansia, Sutterella increase in abundance after fed with M3G for three weeks. A significantly smaller abundance of Proinflammatory bacteria such as Dorea, Coprobacillus, Clostridium, Streptococcus, Oscillospira in HM mice(p<0.01). Both M3G and chemotherapeutic drugs can increase signal transduction, Membrane transport, and Cell Motility.In addition, the ability of cell growth and death increased in HM and PC groups but decreased in LC and LM groups. This study indicates that M3G supplementation for three weeks may not be enough to cure liver cancer. However, M3G-supplementation was associated with significant

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Papiospp. Colon microbiome and its link to obesity in pregnancy

Abstract: Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.

Cited by 4 publications

References 76 publications

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing

Significant Microbial Changes Are Evident in the Reproductive Tract of Pregnant Rhesus Monkeys at Mid-Gestation but Their Gut Microbiome Does Not Shift until Late Gestation

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