<i>Parasutterella</i>, in association with irritable bowel syndrome and intestinal chronic inflammation

Chen, Yanjie; Wu, Hao; Wu, Shengdi; Lü, Nan; Wang, Yiting; Liu, Hai-Ning; Dong, Ling; Liu, Taotao; Shen, Xin

doi:10.1111/jgh.14281

Cited by 209 publications

(151 citation statements)

References 23 publications

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“…Parasutterella excrementihominis belongs to a newly studied genera Parasutterella with limited literature. An increase in Parasutterella excrementihominis has been found in ileal submucosal tissue of Crohn's disease patients [23] and in fecal samples of irritable bowel syndrome (IBS) patients [24]. Our analysis also revealed a decreased abundance of Phascolarctobacterium succinatutens in psoriasis compared to the controls (Fig.…”

Section: Identi Cation Of Microbial Features Associated With the Psorsupporting

confidence: 57%

Metagenomic Analysis of the Gut Microbiome in Psoriasis Reveals Three Subgroups with Distinct Host-Microbe Interactions

Chang

Yan

Singh

et al. 2020

Preprint

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Background Psoriasis is a chronic, inflammatory skin disease that impacts 2–3% of the global population. Besides skin manifestations, psoriasis patients have increased susceptibility to a number of comorbidities including psoriatic arthritis, cardiovascular disease, and inflammatory bowel disease. To understand the systemic component of psoriasis pathogenesis, we examined the fecal metagenome, host colonic transcriptome, and host peripheral blood immune profiles of psoriasis patients and healthy controls. Results Our analysis showed increased functional diversity in the gut microbiome of psoriasis patients. In addition, we identified microbial species that preferentially associate with psoriasis patients and which have been previously found to associate with other autoimmune diseases. Intriguingly, our data reveal new insights about psoriasis disease heterogeneity, as we identified three psoriasis subgroups that have distinct microbial and host features. Finally, integrating microbial and host features revealed host-microbe interactions that are specific to psoriasis or particular psoriasis subgroups. Conclusion To our knowledge, this is the first study that provides a comprehensive view of gut microbial function and corresponding host response in psoriasis patients. Our findings provide insight into factors that may affect the development of comorbidities in psoriasis patients and may hold diagnostic potential for early identification of psoriasis patients at risk for these comorbidities.

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Section: Identi Cation Of Microbial Features Associated With the Psorsupporting

confidence: 57%

Metagenomic Analysis of the Gut Microbiome in Psoriasis Reveals Three Subgroups with Distinct Host-Microbe Interactions

Chang

Yan

Singh

et al. 2020

Preprint

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“…Lactobacillus is a genus of commensal bacteria that exist either as facultative anaerobes or as microaerophiles, which have demonstrated the association with the intestinal integrity, translocation of intestinal microbial products, and alleviation of ALD (Wang et al., ). Parasutterella , a kind of Gram‐negative bacteria, has shown an increase in inflammatory disease (Chen et al., ). Other recent studies also have described that inulin supplementary can alleviate gut dysbiosis by alteration of Proteobacteria and Actinobacteria in vitro and animal models (Beloshapka et al., ; Johnson‐Henry et al., ; Wiese et al., ).…”

Section: Discussionmentioning

confidence: 99%

Inulin Ameliorates Alcoholic Liver Disease via Suppressing LPS‐TLR4‐Mψ Axis and Modulating Gut Microbiota in Mice

Yang

Zhang

et al. 2019

Alcoholism Clin & Exp Res

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Background: Alcoholic liver disease (ALD) represents a chronic liver disorder caused by alcohol abuse. Numerous studies have demonstrated that gut microbiota dysbiosis plays a critical role in ALD pathogenesis. Application of prebiotic, probiotic, and dietary supplementation to the modulation of gut microbiota contributes to a novel approach to the management of ALD. Inulin, a natural prebiotic found in plants, can restore gut dysbiosis in ALD. However, the exact mechanism of dietary inulin in ALD remains largely unknown.Methods: Sixty female C57BL/6J mice were randomly divided into 4 groups: pair-fed (PF) group (PF/CON); alcohol-fed (AF) group (AF/CON); PF with inulin (INU) group (PF/INU); and AF with INU group (AF/INU). All mice were fed with isocaloric modified Lieber-DeCarli liquid diets with or without alcohol.Results: After 6 weeks of feeding, mice were euthanized and associated indications were investigated. The results showed that chronic ethanol (EtOH) intake led to the loss of body weights, abnormal levels of transaminases, and inflammatory indicators (lipopolysaccharide [LPS], interleukin [IL]-6, IL-10, tumor necrosis factor-a, IL-17A), while inulin administration ameliorated these effects. To further understand the underlying mechanism, we investigated macrophages (Mws) and gut microbiota in diverse groups. The number of Mws was reduced after dietary inulin treatment in chronic EtOH exposure. Hepatic Toll-like receptor 4 (TLR4 + ) Mws in AF/INU group were lower than AF/CON group. 16S rRNA sequencing and analysis of gut microbiota indicated the reduction of Allobaculum, Lactobacillus, and Lactococcus, as well as the increase of Parasutterella in AF group compared with PF control. Increased Allobaculum, Lactobacillus, and Lactococcus but reduced Parasutterella in AF/INU group were confirmed that dietary inulin rectified gut dysbiosis to attenuate ALD.Conclusions: Dietary inulin ameliorates ALD via suppressing LPS-TLR4-Mw axis and modulating gut microbiota in mice, thus potentially provides theoretical foundation for inulin intervention in the prevention and treatment of ALD.

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“…We found that metronidazole caused gut dysbiosis with increased susceptibility to colonization by Proteobacteria and enrichment of Erysipelotrichales in the treated SPF mice. A recent report suggested that an increase in Parasutterella is associated with the development and progression of irritable bowel syndrome (IBS) and chronic inflammation of the intestine [33]. Transferring aged gut microbiota to young GF mice led to an increase in Proteobacteria involved in inflammatory aging and inflammation of the small intestine [34].…”

Section: Discussionmentioning

confidence: 99%

Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism

Manickam

Tan

et al. 2018

IJMS

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Antibiotics lead to increased susceptibility to colonization by pathogenic organisms, with different effects on the host-microbiota relationship. Here, we show that metronidazole treatment of specific pathogen-free (SPF) mice results in a significant increase of the bacterial phylum Proteobacteria in fecal pellets. Furthermore, metronidazole in SPF mice decreases hind limb muscle weight and results in smaller fibers in the tibialis anterior muscle. In the gastrocnemius muscle, metronidazole causes upregulation of Hdac4, myogenin, MuRF1, and atrogin1, which are implicated in skeletal muscle neurogenic atrophy. Metronidazole in SPF mice also upregulates skeletal muscle FoxO3, described as involved in apoptosis and muscle regeneration. Of note, alteration of the gut microbiota results in increased expression of the muscle core clock and effector genes Cry2, Ror-β, and E4BP4. PPARγ and one of its important target genes, adiponectin, are also upregulated by metronidazole. Metronidazole in germ-free (GF) mice increases the expression of other core clock genes, such as Bmal1 and Per2, as well as the metabolic regulators FoxO1 and Pdk4, suggesting a microbiota-independent pharmacologic effect. In conclusion, metronidazole in SPF mice results in skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation.

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Parasutterella, in association with irritable bowel syndrome and intestinal chronic inflammation

Abstract: Parasutterella may be related with the genesis and development of IBS and also associated with chronic intestinal inflammation in IBS patients.

Cited by 209 publications

References 23 publications

Metagenomic Analysis of the Gut Microbiome in Psoriasis Reveals Three Subgroups with Distinct Host-Microbe Interactions

Metagenomic Analysis of the Gut Microbiome in Psoriasis Reveals Three Subgroups with Distinct Host-Microbe Interactions

Inulin Ameliorates Alcoholic Liver Disease via Suppressing LPS‐TLR4‐Mψ Axis and Modulating Gut Microbiota in Mice

Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism

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