Pasteurella multocidameningoencephalitis in an immunocompetent adult with multiple cat scratches

Clarke, David Alistair; McBride, Angela; Kelsey, M.C.; Killingley, Ben

doi:10.1136/bcr-2016-219021

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…Infrequent and unlikely complications such as meningitis, endocarditis, and septic arthritis have also been associated with P. multocida [ 6 , 7 ]. A case study by Clarke et al, treated a patient who presented with symptoms consistent with meningitis [ 7 ]. The causative organism was discovered after a lumbar puncture revealed P. multocida in the cerebrospinal fluid (CSF).…”

Section: Discussionmentioning

confidence: 99%

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Pasteurella multocida Bacteremia in an Immunocompromised Patient After Multiple Cat Scratches

Boadu

Hernández

Zeidan

et al. 2021

Cureus

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Pasteurella multocida (P. multocida) is a zoonotic organism found in the normal flora of domestic and wild animals. In this case report, we present a 70-year-old Caucasian male who presented with fever, chills, and greenish sputum which began hours prior to presentation. His symptoms were initially thought to be due to refractory pneumonia because the patient had been discharged from our hospital three weeks prior to presentation. Blood cultures grew P. multocida , a rare pathogen to cause bacteremia. He was treated with cefepime and later amoxicillin/clavulanic acid and made an uneventful recovery. Later history of the patient’s cats scratching him was thought to be the mode of transmission. P. multocida infection is rare, and can also be dangerous and even fatal in immunocompromised individuals. Clinicians must therefore operate with a high degree of suspicion especially when treating immunocompromised patients with bacteremia.

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Section: Discussionmentioning

confidence: 99%

“…The causative organism was discovered after a lumbar puncture revealed P. multocida in the cerebrospinal fluid (CSF). The patient was successfully treated with IV ceftriaxone and amoxicillin [ 7 ]. It was soon disclosed that the patient had likely contracted it from her pet dog.…”

Section: Discussionmentioning

confidence: 99%

Pasteurella multocida Bacteremia in an Immunocompromised Patient After Multiple Cat Scratches

Boadu

Hernández

Zeidan

et al. 2021

Cureus

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“…P. multocida is usually sensitive to penicillin, ampicillin and third generation cephalosporins [ 12 ]. IV Ampicillin 2 g every 4 hourly or IV ceftriaxone 2 g every 12 hourly are suitable initial options [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

A case report of Pasteurella multocida meningitis in a patient with non-traumatic skull base defect

Sabra

Khan

Samawi

et al. 2020

IDCases

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Background Pasteurella multocida is a gram-negative coccobacillus that is primarily found in oropharynx of dogs, cats and other animals. It causes infections in human beings through contact with animal saliva in the form of licks, bites and scratches of animals colonized by the bacteria. Meningitis due to Pasteurella multocida is rare in immunocompetent individuals. We report a case of meningitis due to Pasteurella multocida in an immunocompetent patient. Case report A 30-year-old gentleman presented with 2-day history of fever and neck stiffness. 6 weeks earlier, he was treated as a case of bacterial meningitis. During that hospital stay, he was diagnosed to have bony defect in the sellar floor based on MRI head performed to evaluate for a prolonged history of CSF rhinorrhea. He was discharged and scheduled for an elective endoscopic endonasal/open repair of the skull base defect after resolution of meningitis. CSF findings during current admission also showed features of bacterial meningitis. CSF culture showed Pasteurella multocida sensitive to penicillin, ampicillin and ceftriaxone. Retrospective history revealed patient’s contact with stray cats as he used to feed them but there was no history of licks, bites. He was treated with intravenous ceftriaxone 2 g twice a day for 14 days with complete resolution of his symptoms. Conclusion Pasteurella multocida is an important cause of bacterial meningitis in patients with skull defect. Patients with traumatic or non-traumatic bony defect of skull should avoid contact with dogs and cats to prevent the spread of infection the central nervous system.

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“…Case reports have demonstrated sequelae of disseminated infection that may hematogenously spread and cause pneumonia, lung abscess, empyema, septic joint, osteomyelitis, intra-abdominal and central nervous system infection. Rare cases of endocarditis and ocular infections have been documented [4,[7][8][9][10][11][12][13]. Dissemination is responsive to treatment but carries a significant mortality risk of about 30% [7] warranting hospitalization and supportive care in addition to appropriate antimicrobials.…”

Section: Discussionmentioning

confidence: 99%

Pasteurella multocida Bacteremia and Osteomyelitis from a Diabetic Foot Ulcer

Randhawa¹,

Woytanowski²,

Schultz³

et al. 2017

AJMCR

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Pasteurella multocida is a gram-negative coccobacillus that causes a spectrum of illnesses. P multocida lives as commensal bacteria in the upper respiratory tracts of fowl and mammals. Infections most commonly result from cat or dog bites; however, direct inoculation via saliva has been reported. Although the majority of P. multocida infections manifest in skin and soft tissue, it may cause bacteremia with disseminated infection in an immunocompromised host. Dissemination is responsive to treatment but carries a significant mortality risk of about 30%. We present a case of a 46 year old male with type 2 diabetes mellitus, coronary artery disease and chronic kidney disease with stage 4 neuropathic heel ulcer who presented with hypothermia and chills. One day into admission, 4/4 blood culture bottles were positive for Pasteurella multocida. MRI of the foot was concerning for osteomyelitis which was confirmed via I&D. The patient did report having a dog and a cat at home, but adamantly denied any bites from either animal. Examination of his boot used for support with his foot containing the ulcer revealed extensive animal hair stuck to the boot. It was deemed likely that the route of inoculation occurred from contamination of his neuropathic ulcer from his dog's saliva, likely from a lick, for which his diabetic neuropathy may have impaired initial sensation of the contamination. The patient was treated with ampicillin-sulbactam while admitted and discharged with oral levofloxacin 6 week course for residual osteomyelitis.

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Pasteurella multocidameningoencephalitis in an immunocompetent adult with multiple cat scratches

Cited by 6 publications

References 15 publications

Pasteurella multocida Bacteremia in an Immunocompromised Patient After Multiple Cat Scratches

Pasteurella multocida Bacteremia in an Immunocompromised Patient After Multiple Cat Scratches

A case report of Pasteurella multocida meningitis in a patient with non-traumatic skull base defect

<i>Pasteurella</i><i> </i><i>multocida</i><i> </i>Bacteremia and Osteomyelitis from a Diabetic Foot Ulcer

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