<i>PCSK9</i> E670G (rs505151) Variant and Coronary Artery Disease Risk Among Diabetics

Mohamed, Samy Hassanin; Hassaan, Mohamed M M; Ibrahim, Basma A; Sabbah, Norhan A.

doi:10.1089/gtmb.2021.0010

Cited by 8 publications

(2 citation statements)

References 38 publications

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“…This may be explained by the absence of the GG genotype in our study. It is noteworthy that patients with DM present a signi cantly higher frequency of the G allele than patients without DM (Slimani et al, 2014;Mohamed et al, 2021). Additionally, the small sample size (13 DM cases with CAD vs. 18 DM cases without CAD) limits the power of this analysis to only some risk factors.…”

Section: Discussionmentioning

confidence: 97%

Proprotein Convertase Subtilisin/Kexin Type 9 Gene Polymorphism (PCSK9) in Coronary Heart Diseases

Eldin,

Saeed,

Osman

et al. 2023

Preprint

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Background Genetic variation in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has been identified as an important determinant of plasma LDL-C and the severity of coronary heart disease. Aim The aim of the study was to study the association between the single-nucleotide polymorphism (SNP) of PCSK9 E670G (rs505151) and CAD. Patients andMethods The present study is a case‒control study conducted on patients recruited from Internal Medicine Specialized Hospital (Cardiology Department), Mansoura University, from July 2019 to August 2020. One hundred patients with coronary heart disease, in addition to 100 apparently healthy age- and sex-matched subjects, were recruited from outpatient clinics to act as the control group (non-CAD). Results The AG genotype was significantly associated with higher TG than the AA genotype, while TC, HDL-C, LDL-C and non-HDL-C did not differ significantly between genotypes among the studied CAD groups. However, there was a nonsignificantly higher frequency of high risk levels of TC, LDL-C and non-HDL-C in the AG genotype than in the AA genotype in CAD cases. Furthermore, no significant difference was found regarding family history, DM, hypertension, BMI, TC, TG, HDL-C, LDL-C and non-HDL-C between the PCSK9 genotypes in the CAD group. Conclusion PCSK9 AG genotype and G allele carriers were significantly associated with a potential risk of CAD development. Furthermore, the presence of a risk allele could provide information regarding targeted preventive intervention (PCSK9 inhibitors).

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Section: Discussionmentioning

confidence: 97%

Proprotein Convertase Subtilisin/Kexin Type 9 Gene Polymorphism (PCSK9) in Coronary Heart Diseases

Eldin,

Saeed,

Osman

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Saavedra et al [ 16 ] found that the incidence of diabetes and prediabetes was twice as high in familial hypercholesterolemia (FH) individuals carrying the PCSK9-InsLEU gene mutation as in non-carriers. Mohamed et al demonstrated that PCSK9 relative expression levels and the E670G (rs505151) AG genotype are cardiovascular disease risk factors among Egyptian diabetics [ 17 ]. However, the relationship between PCSK9 genetic polymorphisms and T2DM remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Association of genetic polymorphisms of PCSK9 with type 2 diabetes in Uygur Chinese population

Wang

Yan

et al. 2022

BMC Cardiovasc Disord

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Background PCSK9 gene expression is associated with biological processes such as lipid metabolism, glucose metabolism, and inflammation. In the present study, our primary objective was to assess the association between the single-nucleotide polymorphisms in the PCSK9 gene and type 2 diabetes in Uygur subjects, in Xinjiang, China. Methods We designed a case–control study including 662 patients diagnosed with T2DM and 1220 control subjects. Four single-nucleotide polymorphisms (rs11583680, rs2483205, rs2495477 and rs562556) of PCSK9 gene were genotyped using the improved multiplex ligation detection reaction technique. Results For rs2483205, the distribution of genotypes, dominant model (CC vs CT + TT), overdominant model (CC + TT vs CT) showed significant differences between T2DM patients and the controls (P = 0.011 and P = 0.041 respectively). For rs2495477, the distribution of genotypes, the dominant model (AA vs GA + GG) showed significant differences between T2DM patients and the controls (P = 0.024). Logistic regression analysis suggested after adjustment of other confounders, the differences remained significant between the two groups [for rs2483205 CC vs CT + TT: odds ratio (OR) = 1.321, 95% confidence interval (CI) 1.078–1.617, P = 0.007; CC + TT vs CT: OR = 1.255, 95% CI 1.021–1.542, P = 0.03; for rs2495477 AA vs GA + GG: OR = 1.297, 95% CI 1.060–1.588, P = 0.012]. Conclusion The present study indicated that CT + TT genotype and CT genotype of rs2483205, as well as GA + GG genotype of rs2495477 in PCSK9 gene were associated with an increased risk of type 2 diabetes in the Uygur population in Xinjiang.

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The Predictive Utility of Circulating PCSK9 Levels on Diabetic Retinopathy Stage

Karapapak,

Kara,

Düzgün

2024

Current Eye Research

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PCSK9 E670G (rs505151) Variant and Coronary Artery Disease Risk Among Diabetics

Cited by 8 publications

References 38 publications

Proprotein Convertase Subtilisin/Kexin Type 9 Gene Polymorphism (PCSK9) in Coronary Heart Diseases

Proprotein Convertase Subtilisin/Kexin Type 9 Gene Polymorphism (PCSK9) in Coronary Heart Diseases

Association of genetic polymorphisms of PCSK9 with type 2 diabetes in Uygur Chinese population

The Predictive Utility of Circulating PCSK9 Levels on Diabetic Retinopathy Stage

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