<i>Peganum</i> spp.: A Comprehensive Review on Bioactivities and Health‐Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs

Sharifi‐Rad, Javad; Quispe, Cristina; Herrera‐Bravo, Jesús; Semwal, Prabhakar; Painuli, Sakshi; Özçelik, Beraat; Hacıhasanoğlu, Furkan Ediz; Shaheen, Shabnum; Sen, Surjit; Acharya, Krishnendu; Amirian, Marjan; Castillo, Carla Marina Salgado; López, María Dolores; Schoebitz, Mauricio; Martorell, Miquel; Goloshvili, Tamar; Al‐Harrasi, Ahmed; Al‐Rawahi, Ahmed; Kumar, Manoj; Suleria, Hafiz Ansar Rasul; Cho, William C.

doi:10.1155/2021/5900422

Cited by 19 publications

(10 citation statements)

References 91 publications

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Section: The Collection Of Hairy Roots Of the Institute Of Plant Phys...mentioning

confidence: 99%

“…Peganum harmala L. (Zygophyllaceae) is a perennial herbaceous plant common in the Mediterranean region of Europe, Central Asia, and southern South America [90,91]. It refers to medicinal plants widely used in folk and traditional Chinese medicine for the treatment of various human diseases [90][91][92][93][94]. The therapeutic effect of extracts from seeds and vegetative parts of the plant is explained by the presence of two classes of alkaloids-quinazoline and indole β-carboline type.…”

Section: The Collection Of Hairy Roots Of the Institute Of Plant Phys...mentioning

confidence: 99%

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Collection of Hairy Roots as a Basis for Fundamental and Applied Research

et al. 2022

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Due to population growth, instability of climatic conditions, and reduction of the areas of natural ecosystems, it becomes necessary to involve modern biotechnological approaches to obtain highly productive plant material. This statement applies both to the creation of plant varieties and the production of new pharmaceutical raw materials. Genetic transformation of valuable medicinal plants using Agrobacterium rhizogenes ensures the production of stable and rapidly growing hairy roots cultures that have a number of advantages compared with cell culture and, above all, can synthesize root-specific substances at the level of the roots of the intact plant. In this regard, special attention should be paid to the collection of hairy roots of the Institute of Plant Physiology RAS, Russian Academy of Sciences, the founder of which was Dr. Kuzovkina I.N. Currently, the collection contains 38 hairy roots lines of valuable medicinal and forage plants. The review discusses the prospects of creating a hairy roots collection as a basis for fundamental research and commercial purposes.

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Section: The Collection Of Hairy Roots Of the Institute Of Plant Phys...mentioning

confidence: 99%

Section: The Collection Of Hairy Roots Of the Institute Of Plant Phys...mentioning

confidence: 99%

Collection of Hairy Roots as a Basis for Fundamental and Applied Research

et al. 2022

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“…On top of that, ORA can reverse IL‐1β‐mediated hypertrophic changes in chondrocytes. ORA was shown to have protective benefits via inhibiting NF‐κB and Wnt/β‐catenin signaling (Sharifi‐Rad et al, 2021). The isolated flavonoid licochalcone A found in glycyrrhiza glabra, often known as liquorice.…”

Section: Nutraceuticalsmentioning

confidence: 99%

Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis

Alharbi

Afzal

Altamimi

et al. 2022

Journal of Food Biochemistry

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Osteoarthritis (OA) is a disease due to the aging of the articular cartilage, a post‐mitotic tissue that stays functioning until primary homeostatic processes fail. Because of pain and disability, OA significantly influences national healthcare expenses and patient quality of life. It is a whole‐joint illness characterized by inflammatory and oxidative signaling pathways and significant epigenetic alterations that cause cartilage extracellular matrix degradation. The canonical Wnt pathway (Wnt/β‐catenin pathway) and nuclear factor kappa B (NF‐κB) signaling pathways may function in joint tissues by modulating the activity of synovial cells, osteoblasts, and chondrocytes. However, finding innovative ways to treat osteoarthritis and get the joint back to average balance is still a struggle. Nutraceuticals are dietary supplements that promote joint health by balancing anabolic and catabolic signals. New therapeutic methods for OA treatment have been developed based on many research findings that show nutraceuticals have strong anti‐inflammation, antioxidant, anti–bone resorption, and anabolic properties. For the treatment of osteoarthritis, we explore the possible involvement of nutraceuticals that target the Wnt/β‐catenin and NF‐κB pathways. Practical applications In keeping with the aging population, osteoarthritis is becoming more widespread. In this extensive research, we studied the role of the Wnt/β‐catenin and NF‐κB pathway in OA formation and progression. Nutraceuticals that target these OA‐related signaling pathways are a viable therapy option. Wnt/β‐catenin and NF‐κB signaling pathway are inhibited by polyphenols, flavonoids, alkaloids, and vitamins from the nutraceutical category, making them possible therapeutic drugs for OA therapy.

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“…Harmine, which is mainly derived from the seeds of the medicinal plant Peganum harmala L. ( Li et al, 2017 ; Sharifi-Rad et al, 2021 ), is a natural β -carboline alkaloid compound with numerous pharmacological functions, including anti-inflammatory, neuroprotective ( Li et al, 2018 ), and antiviral functions ( Benzekri et al, 2018 ), as well as the regulation of cellular apoptosis and proliferation ( Zhu et al, 2021 ). For instance, harmine exerts inhibitory effects on LPS-induced inflammatory reactions in the kidney by suppressing the NF-κB and NLRP3 pathways, accompanied by a reduction in TNF- α , IL-6 and IL-1 β levels ( Niu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway

Ruan

Qin

et al. 2022

Front. Cell Dev. Biol.

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Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural β-carboline alkaloid compound, has been shown to exert pharmacological effects on several diseases. Here, we investigated whether harmine protected against SIC development and the underlying mechanisms. In vitro, the expression of the M1 phenotype markers iNOS and COX-2 was increased in RAW 264.7 cells stimulated with lipopolysaccharide (LPS), but this effect was reversed by the harmine intervention. Furthermore, LPS-induced increases in the levels of inflammatory cytokines, including IL-1β, IL-6, TNF-α, iNOS, COX-2, PGE2 and TXB2, generated by macrophages were suppressed when the cells were pretreated with harmine. Meanwhile, our findings showed that harmine administration effectively attenuated inflammation and apoptosis in H9c2 cells in the proinflammatory environment produced by macrophages, as evidenced by reductions in NLRP3 and cleaved caspase 3 levels and the p-NF-κB/NF-κB ratio. The western blot results indicated that the mechanisms underlying harmine-mediated inhibition of M1 polarization might be associated with suppression of STAT1/3, NF-κB and MAPK activation. Furthermore, an LPS injection induced cardiac dysfunction and decreased the survival rate of mice, which were alleviated by harmine treatment, and the relevant mechanism was possibly attributed to a drug-induced attenuation of the inflammatory and apoptotic processes in cardiomyocytes. Collectively, these results implied that harmine treatment protected against SIC by suppressing M1 phenotypic polarization and inflammation in macrophages.

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Peganum spp.: A Comprehensive Review on Bioactivities and Health‐Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs

Cited by 19 publications

References 91 publications

Collection of Hairy Roots as a Basis for Fundamental and Applied Research

Collection of Hairy Roots as a Basis for Fundamental and Applied Research

Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway

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