<i>Pereskia bleo</i> Leaves Extract Induces Cell Death via Cell Cycle Arrest and Apoptosis in Cervical Cancer Cells HeLa

Mohd-Salleh, Siti Farhanah; Wan-Ibrahim, Wan Suriyani; Ismail, Norzila

doi:10.1080/01635581.2019.1654530

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Some studies reported the antiproliferative properties and mechanism of actions of P. bleo extracts against selected human cancer cell lines, i.e. nasopharyngeal epidermoid carcinoma, colon carcinoma, cervical and breast carcinoma [4,6,[12][13][14] . Breast and prostate cancers were the conditions for which P. bleo was used by our participants.…”

Section: Medical Conditionsmentioning

confidence: 99%

Medicinal uses of a leafy cactus, Pereskia bleo, in Singapore: A survey on the users' knowledge and their perceptions

Zareisedehizadeh¹,

Siew²,

Wee³

et al. 2022

Int. J. Herb. Med.

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Pereskia bleo is a leafy cactus traditionally used for various purposes. We aim to study the information about the usage, preparation methods, effects and possible unwanted effects of Pereskia bleo from the users of fresh medicinal plants in Singapore. The participants were recruited through advertisement and interviewed. Data was evaluated using thematic analysis and statistical methods. From 25 participants, 36% used this plant for treatment of medical conditions such as breast, lung and prostate cancers and constipation, 32% for health promotion like detoxification and improving blood flow and immunity, and 32% for both. Reported side effects were mild and reversible pruritus, diarrhea, cold sensation and weakness in the feet, and increased prothrombin time caused by potential herb-drug interaction. Studies are needed to further explore the potential therapeutic effects and possible herb-drug interactions. Moreover, healthcare professionals should actively enquire about the concurrent usage of fresh medicinal plants including Pereskia bleo by patients to monitor for possible interactions.

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Section: Medical Conditionsmentioning

confidence: 99%

Medicinal uses of a leafy cactus, Pereskia bleo, in Singapore: A survey on the users' knowledge and their perceptions

Zareisedehizadeh¹,

Siew²,

Wee³

et al. 2022

Int. J. Herb. Med.

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“…Cancer is a group of malignant diseases characterized by uncontrolled, abnormal cells (Gurunanselage Don & Yap, 2019). It has been categorized as a disease with a high death rate in human history despite advancements in tools for diagnosis, treatment, and prevention (Mohd-Salleh et al, 2020). Although with various treatments and progress in reducing cancer incidence and development in chemotherapeutic strategies, the cases keep increasing and are still a significant public health problem worldwide (Mahmood et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Review of Malaysian Medicinal Plants with Potential Anticancer Activity

Jusoh

Aris

Jalil

et al. 2023

MAB

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The global cancer incidence and its high mortality rate indicate limitations in its current treatment and chemotherapeutic strategies. This sparked a worldwide interest in the demand for chemical diversity in searching for therapeutic drugs derived from natural products. Natural products from medicinal plants, whether as pure compounds or crude extracts, offer inexhaustible sources of new drugs because of their unparalleled chemical diversity. This review aims to disseminate detailed information on the anticancer potential of Malaysian medicinal plants, focusing on the bioactive phytochemicals and mechanisms of action against cancer development in both in vitro and in vivo studies. A comprehensive search of PubMed, Google Scholar, Scopus, and ScienceDirect databases was conducted to find relevant articles on the anticancer activity of Malaysian medicinal plants. A total of hundred and twenty-two (122) articles on the anticancer activity of Malaysian medicinal plants was identified and reviewed. Eighty-five (85) plants (in vitro) and 16 plants (in vivo) have been identified to possess anticancer activity. The activity reported was attributed primarily to diverse chemical groups of naturally occurring phytochemicals such as flavonoids, phenolics, glycosides, quercetin, and gallic acid. Henceforth, the findings will hope to aid further research in understanding the underlaying mechanism and the efficiency of the isolation of the bioactive compounds.

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Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies

Ismail

Zainudin

Hua

2021

Journal of Complementary and Integrative Medicine

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Objectives Level of βhCG and the presence of any uterine mass of hydatidiform mole need a careful review or monitoring in order to prevent metastasis, provide an early treatment and avoid unnecessary chemotherapy. Case presentation A 36-year old fifth gravida patient who had a missed abortion was diagnosed as having a molar pregnancy with beta human chorionic gonadotrophin (βhCG) level of 509,921 IU/L. Her lung field was clear and she underwent suction and curettage (S & C) procedure. However, after six weeks, AA presented to the emergency department with a massive bleeding, although her βhCG level had decreased to 65,770 IU/L. A trans-abdominal ultrasound indicated the presence of an intra-uterine mass (3.0 × 4.4 cm). Nevertheless, her βhCG continued to show a declining trend (8,426 IU/L). AA was advised to undergo a chemotherapy but she refused, citing preference for alternative medicine like herbs instead. She opted for an “at own risk” (AOR) discharge with scheduled follow up. Subsequently, her condition improved with her βhCG showing a downward trend. Surprisingly, at six months post S & C, her βhCG ameliorated to 0 IU/L with no mass detected by ultrasound. Conclusions Brucea javanica fruits, Pereskia bleo and Annona muricata leaves can potentially be useful alternatives to chemotherapy and need further studies.

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Pereskia bleo Leaves Extract Induces Cell Death via Cell Cycle Arrest and Apoptosis in Cervical Cancer Cells HeLa

Cited by 6 publications

References 35 publications

Medicinal uses of a leafy cactus, Pereskia bleo, in Singapore: A survey on the users' knowledge and their perceptions

Medicinal uses of a leafy cactus, Pereskia bleo, in Singapore: A survey on the users' knowledge and their perceptions

Review of Malaysian Medicinal Plants with Potential Anticancer Activity

Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies

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