<i>Perilla frutescens</i> seed oil combined with <i>Anredera cordifolia</i> leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health

Hashimoto, Michio; Matsuzaki, Kei; Maruyama, Koji; Sumiyoshi, Eri; Hossain, Shahdat; Wakatsuki, Harumi; Kato, Setsushi; Ohno, Miho; Tanabe, Yoko; Kuroda, Yoko; Yamaguchi, Shûhei; Koyama, Koji; Ohizumi, Yasushi; Shido, Osamu

doi:10.1039/d2fo00723a

Cited by 11 publications

(9 citation statements)

References 73 publications

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“…The characteristics of the included studies are presented in Table 1 . A total of 158 rat models and five studies [ 22 , 23 , 24 , 25 , 26 ] were included in the meta-analysis, while other studies were excluded mainly because the statistical analyses were not informative when using insufficient data. For the purpose of this meta-analysis, we evaluated the therapeutic effects of Perilla frutescens on animal models that were mentioned at least twice.…”

Section: Resultsmentioning

confidence: 99%

“…Although these effects resulted from the analysis of in vitro and in vivo studies, there were few clinical trials that outlined significant therapeutic effects for human subjects. Attenuation of age-related cognitive decline, antiallergic, antioxidant, prokinetic, and antispasmodic effects are among the proven therapeutic proprieties of Perilla frutescens in these studies [ 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

Adam

Robu

et al. 2023

Pharmaceuticals

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(1) Background: Chronic renal disorders (CRD) are associated with significant comorbidities and necessitate complex therapeutic management. As time passed, Perilla frutescens (PF) became a promising therapeutic option for CRD. The aim of this systematic review and meta-analysis was to outline the therapeutic effects of PF extracts on various models of immunoglobulin a (IgA) nephropathy; (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All prospective interventional studies that evaluated the effect of PF extract versus placebo on rat models of chronic renal disorders were assessed according to the international guidelines; (3) Results: Our search yielded 23 unique records, out of which only five were included in the analysis. Our results showed that administration of PF extracts led to a statistically significant reduction in proteinuria and PCNA levels in rats that received high doses of the extract as well as in the PCNA level and DNA synthesis in rats that received low doses of the extract. The evaluated outcomes benefited from a low degree of heterogeneity; (4) Conclusions: Some of the evaluated outcomes were significantly reduced by both high and low doses of extracts from Perilla frutescens. Further studies are needed to determine the exact effect over IgA nephropathy in human subjects.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

Adam

Robu

et al. 2023

Pharmaceuticals

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“…Previous studies have shown that clinical investigations into the utilization of DHA, EPA, N-3 and PUFAs have become prevalent. 219–222 In recent years, a 12-week double-blind study was conducted to examine the effects of egg yolk choline intake (a key component of lecithin) on cognitive functions in aged males and females, which suggested that continued 300 mg day −1 intake of egg yolk choline could enhance verbal memory. 223 SCFAs, especially butyric acid, are considered important nutritional factors in the human body.…”

Section: Discussionmentioning

confidence: 99%

Gut–brain communication mediates the impact of dietary lipids on cognitive capacity

Fan,

Xu,

Tong

et al. 2024

Food Funct.

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“…Perilla frutescens seeds oil (PO) administration alone or in conjunction with Anredera cordifolia leaf (AC) powder was tested for its influence on cognitive performance in healthy Japanese seniors in a randomized, double-blind, parallel-armed intervention experiment [ 87 ]. Participants were randomly assigned to receive either 1.47 mL of PO per day or a combination of 1.47 mL of PO and 1.12 g of AC powder per day.…”

Section: Antioxidant and Hypolipemiant Effectsmentioning

confidence: 99%

Applications of Perilla frutescens Extracts in Clinical Practice

et al. 2023

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(1) Background: Perilla frutescens (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell culture studies, so the clinical evidence for the therapeutic effects is poorly outlined. The aim of this review was to provide an updated and thorough understanding of Perilla frutescens applications in clinical practice using data derived from human studies, and to outline the potential directions and perspectives for further studies on this crop. (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All interventional studies that evaluated the effect of Perilla frutescens in human subjects were assessed. (3) Results: The main perspectives that can be contoured from the presented literature evaluation are an important clinical effect of Perilla frutescens extracts on allergic rhinoconjuctivitis, especially in young populations, a potent hypolipemiant effect that, in conjunction with increased serum biological antioxidant potential, determines significant improvements in cognitive function and a wide variety of miscellaneous clinical effects that need further exploration. (4) Conclusions: Supplementary research is needed in order to demonstrate the therapeutic effects of Perilla frutescens in controlled clinical settings.

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Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health

Abstract: Supplementation of PO + AC for 12-month improved cognitive function in healthy Japanese elderly, presumably by lowering serum triglyceride, blood glucose and N-(epsilon)-carboxymethyl-lysine.

Cited by 11 publications

References 73 publications

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis

Gut–brain communication mediates the impact of dietary lipids on cognitive capacity

Applications of Perilla frutescens Extracts in Clinical Practice

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