Physical Methods Simulating Mechanisms of the Human Cough

Mechanical Insufflation-Exsufflation vs. Tracheal Suctioning via Tracheostomy Tubes for Patients with Amyotrophic Lateral Sclerosis

“…In previous studies, MI-E was reported to improve the SpO 2 and vital capacity when it was applied noninvasively via anesthesia masks for patients with neuromuscular disorders during acute respiratory tract infections. 16,17 MI-E has been reported to be able to clear airways for longer periods of time than tracheal suctioning and with fewer complications. 18 The improvement in ventilatory variables by MI-E is probably due to its ability to clear medium and small bronchi in addition to central airways and both the left and the right airways, thereby decreasing dead-space ventilation.…”

The Effect of Mechanical Exsufflation on Respiratory Gas Exchange in Chronic Pulmonary Emphysema

“…Expiration therefore, in contrast to that in other forms of intermittent pressure breathing, is not impeded except for the initial 0.06 second. Expiratory volume flow rates measuring 60 per cent of the rates obtained during maximally vigorous coughs in normal subjects have been attained by this procedure (12).…”

Airway Clearance Techniques for Mechanically Ventilated Patients: Insights for Optimization

“…This therapy was developed in the early 1950s and has been used primarily to assist, noninvasively, airway clearance in patients with neuromuscular weakness. [61][62][63][64] However, its use in mechanically ventilated patients has been increasing in the past few years. 65,66 Only a few studies have investigated the effects of MI-E in critically ill mechanically ventilated subjects.…”