<i>Pichia anomala</i>pneumonia in a patient with acute lymphoblastic leukemia on maintenance therapy

Sugano, Hanako; Ueda, Takahiro; Migita, Makoto; Mimura, Shigenao; Maeda, Miho; Sugita, Takashi; Fukunaga, Yoshitaka

doi:10.3109/10428194.2010.488707

Cited by 1 publication

(1 citation statement)

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“…Fungemia was reported in 199 cases (94%), and four cases were eye involvement such as endophthalmitis [ 11 , 47 ] or keratitis [ 18 , 21 ]. Major risk factors for fungemia include central venous catheter insertion with parenteral nutrition, low birth weight, and being immunocompromised, such as having a hematologic malignancy [ 3 , 5 , 15 , 20 , 33 , 34 , 37 , 41 ]. Additionally, the use of broad-spectrum antibiotics may also be a risk factor for Wickerhamomyces anomalus fungemia [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Fungemia With Wickerhamomyces anomalus: A Case Report and Literature Review

Sakai,

Taniguchi,

Herai

et al. 2024

Cureus

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We report the case of an 84-year-old man with a history of IgG4-related sclerosing cholangitis who was diagnosed with advanced esophageal cancer and underwent radiation and chemotherapy. An implantable central venous access port was placed for chemotherapy and total parenteral nutrition. The patient presented with a fever and received antimicrobial therapy for acute cholangitis but remained febrile, and subsequently, yeast was detected in the aerobic bottle of blood culture obtained from the central venous line. The yeast was identified as Wickerhamomyces anomalus . Liposomal amphotericin B was administered, and the central line access port was removed. After confirmation of negative blood cultures and 14 days post treatment, he underwent reinsertion of the central line access port. Due to persistent pain at the insertion site, fluconazole was added for an additional 14 days, and the patient was discharged and transferred to another hospital. Wickerhamomyces anomalus is a rare fungal infection with other synonyms including Pichia anomala , Hansenula anomala , and Candida pelliculosa . A literature review of 53 case reports of Wickerhamomyces anomalus , Pichia anomala , Hansenula anomala , and Candida pelliculosa was conducted, with a total of 211 cases reviewed. Fungemia was reported in 94% of cases, with central venous catheterization, parental feeding, low birth weight, and immunocompromised status identified as major risk factors. The majority of cases were pediatric, particularly neonatal, and there were reports of nosocomial infections causing outbreaks, with some cases involving the eye such as endophthalmitis or keratitis.

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