<i>Pimpinella anisum L.</i> ethanolic extract ameliorates the gentamicin‐ induced nephrotoxicity in rats

Changizi-Ashtiyani, Saeed; Seddigh, Amirhassan; Najafi, Hossein; Hossaini, N; Avan, Amir; Akbary, Ahmad; Manian, Mostafa

doi:10.1111/nep.12953

Cited by 22 publications

(10 citation statements)

References 29 publications

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“…Thus, the administration of antioxidants that counteract oxidative stress may protect kidneys from damage. Nephrotoxicity studies have confirmed the authentic roles of bioactive compounds to reduce chronic renal failure [27,[34][35][36]. The present study investigated CURC effects on OTA-induced toxicity using an in vivo animal model.…”

Section: Discussionmentioning

confidence: 73%

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

et al. 2020

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Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both the dose and duration of exposure. According to the scientific data currently available, the mechanism of action still is not completely clarified, but it is supposed that oxidative stress is responsible for OTA-induced nephrotoxicity. Bioactive compound use has emerged as a potential approach to reduce chronic renal failure. Therefore, curcumin (CURC), due to its therapeutic effects, has been chosen for our study to reduce the toxic renal effects induced by OTA. CURC effects are examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. The end result of the experiment finds rats treated with OTA show alterations in biochemical and oxidative stress parameters in the kidney, related to a decrease in the Glomerular Filtration Rate (GFR). Conversely, the administration of CURC attenuates oxidative stress and prevents glomerular hyperfiltration versus the OTA group. Furthermore, kidney histological tests show a reduction in glomerular and tubular damage, inflammation and tubulointerstitial fibrosis. This study shows that CURC can mitigate OTA–induced oxidative damage in the kidneys of rats.

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Section: Discussionmentioning

confidence: 73%

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

et al. 2020

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“…Womeni et al (2013) found that the powder of Pimpinella anisum has a special potent antioxidants for stablization of crude soybean oil. Changizi et al (2017) observed that the simultaneous use of ethanolic extract of P. anisum during gerntamicin (GM) administration is recommended to reduce its nephrotoxicity effects. Barbalho et al (2015) reported that P. anisum has potential to be used to control lipid levels.…”

Section: Anise Nutritional Composition and Chemical Constituentsmentioning

confidence: 99%

Chinese star anise and anise, magic herbs in traditional Chinese medicine and modern pharmaceutical science

Shahrajabian

Sun

Cheng

2019

Asian J. Med. Biol. Res

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Star anise (Illicium verum Hook. f.) is an important herb in traditional Chinese medicine as well as traditional Asian medicine. The fruit is aromatic and has a strong, pungent and mildly sweet taste. Star anise is one of the many species that contain bioactive compounds as well as a number of phenolic and flavonoid compounds, having antioxidant, preservative and antimicrobial properties. All relevant papers in the English language from researchers of different countries were collected. The keywords of Chinese star anise, anise, traditional Chinese medicine and modern pharmaceutical science were searched in Google Scholar, Scopus, Research Gate and PubMed. Its seeds are good source of minerals like calcium, iron, copper, potassium, manganese, zinc, and magnesium. The essential oil of Chinese star anise contains anethole which has shown several functional properties including antimicrobial, antioxidant, hypoglycemic, hypolipidemic and oestrogenic properties. Due to all positive characteristics, such as antidiabetic, hypolipidemic, antioxidant activities, anticancer and antimicrobial properties, both seeds and essential oils of anise is promising for safe use as super food supplements and raw constituents in the both pharmaceutical and food industries. Anise seed oil contains anethol, estragole, eugenol, pseudisoeugenol, methyl chavicol and anisaldehyde, coumarins, scopoleting, umbelliferon, estrols, terpene hydrocarbons, and polyacetylenes as the major compounds. The plant oil has both pharmacological and clinical effects. The pharmacological effects consist of antimicrobial, hepatopreotective, anticonvulsant, anti-inflammatory, antispasmodic, bronchodilator, estrogenic, expectorant and insecticidal effects, and clinical effects such as nausea, constipation, menopausal period, virus, diabetes, obesity and sedative action. Combined with a nutritious diet, other traditional Chinese and Asian medicine, Chinese star anise and ansie seed may improve various aspects of health. More clinical studies are necessary to uncover the numerous substances and their effects in ginseng that contribute to public health. Asian J. Med. Biol. Res. June 2019, 5(3): 162-179

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“…A study to investigate the effect of ethanolic Pimpinella anisum L. extract on gentamicininduced nephrotoxicity in rats, reported that the protective effect of this plant was due to its antioxidant activity. In that study, the levels of biochemical factors were lower and antioxidant capacity was higher in P. anisum L. -treated groups than gentamicin-receiving groups (23). Available evidence indicates that antioxidant compounds in B.…”

Section: Discussionmentioning

confidence: 90%

The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury

Asgharian¹,

Lorigooini²,

Rafieian³

et al. 2017

J Nephropathol

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Pimpinella anisum L. ethanolic extract ameliorates the gentamicin‐ induced nephrotoxicity in rats

Abstract: We demonstrated the potential therapeutic impact of P. anisum to attenuate GM-induced nephrotoxicity. Therefore, the simultaneous use of ethanolic extract of P. anisum during GM administration is recommended to reduce its nephrotoxicity effects.

Cited by 22 publications

References 29 publications

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

Chinese star anise and anise, magic herbs in traditional Chinese medicine and modern pharmaceutical science

The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury

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