<i>Pinelliae Rhizoma Praeparatum Cum Alumine</i>Extract: Sedative and Hypnotic Effects in Mice and Component Compounds

Lin, Shanshan; Nie, Bo; Song, Ke; Ren, Yong; Yuan, Zhengzhong

doi:10.1155/2019/6198067

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…Cavidine (alkaloid) and GA (fatty acids) were identified as the core active components linked with the highest number of targets, as alkaloids and fatty acids appear to play an important role in meliorating sleep quality by ascending rapid eye movement sleep and descending sleep fragmentation. [30] The molecular docking results also confirmed that these 2 components exhibited good binding affinity to the hub target genes. It has been reported that cavadine, which is an alkaloid, may extend the circadian period by enhancing RORα function and prolonging the molecular circadian clock period by raising the stability of the PER2 protein in the suprachiasmatic nucleus.…”

Section: Discussionmentioning

confidence: 70%

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

Zhang

Zhang²,

Wang³

et al. 2023

Medicine

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Insomnia is a common sleep-wake rhythm disorder, which is closely associated with the occurrence of many serious diseases. Recent researches suggest that circadian rhythms play an important role in regulating sleep duration and sleep quality. Banxia Shumi decoction (BSXM) is a well-known Chinese formula used to treat insomnia in China. However, the overall molecular mechanism behind this therapeutic effect has not yet been fully elucidated. This study aimed to identify the molecular targets and mechanisms involved in the action of BSXM during the treatment of insomnia. Using network pharmacology and molecular docking methods, we investigated the molecular targets and underlying mechanisms of action of BSXM in insomnia therapy. We identified 8 active compounds from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and the traditional Chinese medicine integrative database that corresponded to 26 target genes involved in insomnia treatment. The compound-differentially expressed genes of the BXSM network indicated that cavidine and gondoic acid could potentially become key components of drugs used for insomnia treatment. Further analysis revealed that GSK3B, MAPK14, IGF1R, CCL5, and BCL2L11 were core targets significantly associated with the circadian clock. Pathway enrichment analysis of Kyoto Encyclopedia of Genes and Genomes revealed that epidermal growth factor receptor tyrosine kinase inhibitor resistance was the most prominently enriched pathway for BSXM in the insomnia treatment. The forkhead box O signaling pathway was also found to be significantly enriched. These targets were validated using the Gene Expression Omnibus dataset. Molecular docking studies were performed to confirm the binding of cavidine and gondoic acid to the identified core targets. To our knowledge, our study confirmed for the first time that the multi-component, multi-target, and multi-pathway characteristics of BXSM may be the potential mechanism for treating insomnia with respect to the circadian clock gene. The results of this study provided theoretical guidance for researchers to further explore its mechanism of action.Abbreviations: BCL2L1 = BCL2 like 1, BSXM = Banxia Shumi decoction, DEGs = differentially expressed genes, EGFR = epidermal growth factor receptor, FOXO = forkhead box O, GO = gene ontology, GA = gondoic acid, GSEA = gene set enrichment analysis, KEGG = Kyoto Encyclopedia of Genes and Genomes, MAPK14 = mitogen-activated protein kinase, MCC = maximum cluster centrality, PPI = protein-protein interaction, ROC = receiver operating characteristic, SD = sleep deprivation, TCM = traditional Chinese medicine.

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Section: Discussionmentioning

confidence: 70%

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

Zhang

Zhang²,

Wang³

et al. 2023

Medicine

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“…Modern scientific research provided evidence that WDT contains compounds including flavonoids, phenols, alkaloids, triterpenoid organic acid, polysaccharides, and phosphodiesterase inhibitors ( Table 3 ), which have been found to possess neuroprotective, neuromodulation, anti-mutagenic, antioxidant, antiemetic, antithrombotic, antipyretic, and anti-inflammatory effects [ 2 , 30 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

Pradhan

Gantenbein

et al. 2022

Medicines

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Background: Chinese herbal medicine is considered relatively safe, inexpensive, and easily accessible. Wen Dan Tang (WDT), a Jing Fang ancient classical Chinese herbal formula with a broad indication profile has been used for several centuries in China to treat various illnesses. Question: Are there evidence-based clinical trials that show that WDT has a significant impact on the treatment of various diseases, especially in patients with migraine and tension-type headaches (TTH)? Methods: This study is based on an online database search using PubMed, Medline, Cochrane Library, AcuTrials, Embase, Semantic Scholar, Jstor, internet research, and review of ancient and modern Chinese medical textbooks regarding WDT and its compounds. Results: There were no studies on WDT in migraine and TTH; therefore, this work gathers and describes data for every single compound in the formula. Conclusion: This study suggests that the bioactive compounds found in WDT composition show potential in treating patients with neurological, psychiatric disorders, cardiovascular diseases, metabolic syndrome, and digestive disorders. Some coherence between WDT in headache reduction and improvements in the quality of life in patients with migraines and TTH could be evaluated, showing positive results of WDT in these patients.

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“…The aqueous extract solution was concentrated to a volume of 100 mL. Finally, the extract solution was filtered using a standard test sieve of 150 μm, freeze-dried and maintained in desiccators at 4°C until use [21,22].…”

Section: Preparation Of Freeze-dried Radix Astragali and Radix Angelimentioning

confidence: 99%

The combination of Radix Astragali and Radix Angelicae Sinensis attenuates the IFN-γ-induced immune destruction of hematopoiesis in bone marrow cells

Liu

Wei

Wang

et al. 2019

BMC Complement Altern Med

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Background: Radix Astragali and Radix Angelicae Sinensis are two herbs that compose Danggui Buxue Tang (an herbal formula for treatment of anemia diseases). In this study, we explored the molecular mechanism and effective targets to immune destruction of bone marrow (BM) cells treated with Radix Astragali, Radix Angelicae Sinensis or a combination of two agents. The potential synergic advantages of two herbs should also be explored. Methods: The constituents of Radix Astragali and Radix Angelicae Sinensis were analyzed by high performance liquid chromatography-electrospray ionization/mass spectrometer system BM cells were separated from limbs of BALB/c mice, and immune destruction was induced with IFN-γ. The percentages of hematopoietic stem cells (HSCs) and CD3 + T cells were detected by flow cytometry. The distribution of T-bet and changes in the combination of SAP and SLAM in BM cells were observed by immunofluorescence. Western blotting was used to assay the expression of key molecules of the eIF2 signaling pathway in BM cells. Results: Seven constituents of Radix Astragali and six constituents of Radix Angelicae Sinensis were identified. The percentages of HSCs increased significantly after treatment with Radix Angelicae Sinensis, especially at high concentrations. The percentages of CD3 + T cells were significantly decreased after Radix Astragali and Radix Angelicae Sinensis treatment. However, the synergistic function of two-herb combinations was superior to that of the individual herbs alone. The distribution of T-bet in BM cells was decreased significantly after Radix Angelicae Sinensis treatment. The number of SLAM/SAP double-stained cells was increased significantly after Radix Astragali treatment at low concentrations. The phosphorylation levels of eIF2α were also reduced after Radix Astragali and Radix Angelicae Sinensis treatment. Conclusions: Radix Astragali and Radix Angelicae Sinensis could intervene in the immunologic balance of T lymphocytes, inhibit the apoptosis of BM cells induced by immune attack, restore the balance of the T cell immune response network and recover the hematopoietic function of HSCs. The synergistic effects of Radix Astragali and Radix Angelicae Sinensis were superior to those of each herb alone.

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Pinelliae Rhizoma Praeparatum Cum AlumineExtract: Sedative and Hypnotic Effects in Mice and Component Compounds

Cited by 8 publications

References 14 publications

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

The combination of Radix Astragali and Radix Angelicae Sinensis attenuates the IFN-γ-induced immune destruction of hematopoiesis in bone marrow cells

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