<i>Piper longum</i>: A review of its phytochemicals and their network pharmacological evaluation

Choudhary, Neha; Singh, Vikram

doi:10.1101/169763

Cited by 9 publications

(5 citation statements)

References 89 publications

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“…The dominant ingredient is Amla , a citrus fruit that is a highly renowned and potent botanical in Ayurveda. The main ingredients of CP, along with their botanical identities, key active biomolecules and specific therapeutic roles, are detailed in Figure 1 and Table 1 [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55].…”

Section: Compositionmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.

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Section: Compositionmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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“…The other amino lipid nature compound, the one corresponding to peak 8, was tentatively identified as N-methyl-N-stearylamine (1-nonadecanamine). This compound has been reported in some works for its antimicrobial potential, being more commonly found in plant species [64][65][66]. It has been also found as a secondary metabolite of Brevibacterium casei [67] and Saccharomyces cerevisiae, with antibiotic activity against Proteus mirabilis [68].…”

Section: Discussionmentioning

confidence: 99%

Identifying the Compounds of the Metabolic Elicitors of Pseudomonas fluorescens N 21.4 Responsible for Their Ability to Induce Plant Resistance

Martin‐Rivilla

Gutiérrez-Mañero

Gradillas

et al. 2020

Plants

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In this work, the metabolic elicitors extracted from the beneficial rhizobacterium Pseudomonas fluorescens N 21.4 were sequentially fragmented by vacuum liquid chromatography to isolate, purify and identify the compounds responsible for the extraordinary capacities of this strain to induce systemic resistance and to elicit secondary defensive metabolism in diverse plant species. To check if the fractions sequentially obtained were able to increase the synthesis of isoflavones and if, therefore, they still maintained the eliciting capacity of the live strain, rapid and controlled experiments were done with soybean seeds. The optimal action concentration of the fractions was established and all of them elicited isoflavone secondary metabolism—the fractions that had been extracted with n-hexane being more effective. The purest fraction was the one with the highest eliciting capacity and was also tested in Arabidopsis thaliana seedlings to induce systemic resistance against the pathogen Pseudomonas syringae pv. tomato DC 3000. This fraction was then analyzed by UHPLC/ESI–QTOF–MS, and an alkaloid, two amino lipids, three arylalkylamines and a terpenoid were tentatively identified. These identified compounds could be part of commercial plant inoculants of biological and sustainable origin to be applied in crops, due to their potential to enhance the plant immune response and since many of them have putative antibiotic and/or antifungal potential.

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“…Herbs databases such as Dr. Dukes DB (26), Phytochemical interaction DB (27), ChEBI (28), and public repositories were utilized to retrieve the list of the isolated compounds from C. Odorata. The chemical structural information i.e.…”

Section: Mining Of Phytocompounds and Drug-like Property Predictionmentioning

confidence: 99%

Cananga odorata (Ylang-Ylang) modulate pathways involved in cancer: Gene set enrichment and network pharmacology approach

Patil¹,

Patil²,

Malgi³

et al. 2023

IJAM

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Traditionally, Cananga odorata Hook. F. & Thomson (Ylang-Ylang) is commonly used to treat various diseases and has been assessed for anti-cancer potency in experimental animal models. However, the affinity of its phytocompounds with multiple proteins involved in the pathogenesis of cancer has not been illuminated yet. The present study was framed to elucidate the molecular mechanisms of Cananga odorata for its anticancer activity via compound-gene set pathway enrichment analysis, network pharmacology, and docking studies. Initially, phytocompounds were retrieved from herbs databases and literature. Structural information of each compound was obtained from the PubChem database. Druggable characteristics and side effects were predicted using MolSoft and ADVERpred. ADMET profile was predicted using PreADMET online server. Possible target proteins of each compound were predicted by BindingDB (p≥0.7). Compounds modulating the target proteins associated with the cancer were separated based on the successful and approved targets available in the Therapeutic Target Database. STRING and KEGG pathway database was used to analyze the molecular pathways modulated by the protein targets. The interaction between compounds, proteins, and pathways was constructed by Cytoscape 3.6.1, and docking of compounds with protein target was performed using AutoDock 4.2. Among 26 compounds, 12 phytocompounds were identified to modulate 34 pathways associated with cancer. 4-hydroxy-5,6,7-trimethoxyflavanone and Reticuline showed the maximum interactions with proteins involved in cancer. All 12 compounds obeyed the rule of five and p-methoxybenzaldehyde scored the highest drug-likeness score. Micheline A and Anonaine showed the highest binding affinity with Ubiquitin-protein ligase E3 (MDM2). The current study provides the molecular documentation of phytocompounds from Cananga odorata in the regulation of multi-proteins and pathways associated with progression of cancer (mainly Gastric, Melanoma, Prostate, and Breast cancer), which can be further investigated via wet-lab protocols.

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Piper longum: A review of its phytochemicals and their network pharmacological evaluation

Cited by 9 publications

References 89 publications

Chyawanprash: A Traditional Indian Bioactive Health Supplement

Chyawanprash: A Traditional Indian Bioactive Health Supplement

Identifying the Compounds of the Metabolic Elicitors of Pseudomonas fluorescens N 21.4 Responsible for Their Ability to Induce Plant Resistance

Cananga odorata (Ylang-Ylang) modulate pathways involved in cancer: Gene set enrichment and network pharmacology approach

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