Piper nigrum and Piperine: An Update

Abstract

Black pepper (Piper nigrum L.) is a very widely used spice, known for its pungent constituent piperine. However, in addition to its culinary uses, pepper has important medicinal and preservative properties, and, more recently, piperine has been shown to have fundamental effects on p-glycoprotein and many enzyme systems, leading to biotransformative effects including chemoprevention, detoxification, and enhancement of the absorption and bioavailability of herbal and conventional drugs. Based on modern cell, animal, and human studies, piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties. In this review, the chemical constituents, biological activities, effects of processing, and future potential of black pepper and piperine have been discussed thoroughly.

Involvement of attenuated antioxidant and Bcl2 signalling property in UV-R/ sunlight irradiated piperine treated ischemia/reperfusion rat model. Highlights

“…6 The insufficiency of natural dietary agents and antioxidants leads to increased cognitive injury in stroke patients. 6,7 PIP is a dietary spice alkaloid derived from piper (piper nigrum) and exhibits multifunctional antioxidant, antiinflammatory, anti-ischemic and antifibrotic properties.…”

“…6 The insufficiency of natural dietary agents and antioxidants leads to increased cognitive injury in stroke patients. 6,7 PIP is a dietary spice alkaloid derived from piper (piper nigrum) and exhibits multifunctional antioxidant, antiinflammatory, anti-ischemic and antifibrotic properties. [6][7][8][9] In addition to this PIP has tendency to act as bioavailability enhancer, inhibitory effect on p-glycoprotein and drug metabolizing enzyme.…”

“…6,7 PIP is a dietary spice alkaloid derived from piper (piper nigrum) and exhibits multifunctional antioxidant, antiinflammatory, anti-ischemic and antifibrotic properties. [6][7][8][9] In addition to this PIP has tendency to act as bioavailability enhancer, inhibitory effect on p-glycoprotein and drug metabolizing enzyme. [10][11][12][13][14][15][16] Further, intravenously administered PIP was found to be 97% bioavailability compare to other route.…”

Green Synthesis of Gold Nanoparticles Using Cinnamomum verum, Syzygium aromaticum and Piper nigrum Extract

“…It has been effectively used as one of the most important constituents in the medical field worldwide. It contains piperidines, pyrrolidines and amides [20].…”

Prophylactic Role of Piperine and Curcumin in Allethrin Altered Hematological and Biochemical Parameters in Swiss Albino Mice

“…Piperine (C 17 H 19 NO 3 ) is an alkaloid found in the fruits and roots of Piper nigrum and Piper longum species of Piperaceae family, with a long history of medicinal use in Indian medicine 9,10 . It exhibits a wide variety of biological effects, which includes; antimetastatic, antithyroid, antidepressant and hepatoprotective activity 11,12 .…”