<i>Pneumocystis carinii</i>Pneumonia in Adults without Predisposing Illnesses

doi:10.1056/nejm199110313251813

Cited by 2 publications

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References 7 publications

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“…We considered the MGUS to be unrelated to the CD4+ lymphocytopenia because MGUS is a B-cell disorder, and in this patient, there were few monoclonal plasma cells in the bone marrow. After the first episode of PCP in this case, chemoprophylaxis was not recommended because there no predisposing illness had been identified ( 3 ). In hindsight, we probably should have screened the blood lymphocyte profile at the first diagnosis of PCP.…”

Section: Discussionmentioning

confidence: 99%

Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients

Sone¹,

Muramatsu²,

Nakao³

et al. 2018

Intern. Med.

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A 67-year-old man was admitted to our hospital complaining of dry cough. Chest computed tomography showed diffuse infiltrates and ground-glass opacities in the bilateral lung fields. Transbronchial lung biopsy specimens showed alveoli filled with yeast-like fungi. With a diagnosis of pneumocystis pneumonia (PCP), he was given oral sulfamethoxazole/trimethoprim, to which he responded well. However, seven months later, PCP relapsed. Analyses revealed a low bronchoalveolar lavage fluid CD4/CD8 ratio of 0.04 and CD4+ lymphocytopenia (250/μL). Despite intensive work-up, we were unable to detect the underlying cause of CD4+ lymphocytopenia; therefore, a final diagnosis of idiopathic CD4+ T-lymphocytopenia was made.

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Section: Discussionmentioning

confidence: 99%

Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients

Sone¹,

Muramatsu²,

Nakao³

et al. 2018

Intern. Med.

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Immunosenescence Revisited

1997

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Immunosenescence refers to the influence of aging on the immune system. Numerous problems are encountered in studying this topic, the main one being the influence of concomitant disease. Despite the great efforts that have been devoted to research in this field, the results of studies performed to date have not been convincing and, until now, no sound scientific evidence has emerged to show that immunosenescence is clinically significant. The only possible exceptions to this are the discovery of a selective defect in cell-mediated immunity and the reactivation of varicella zoster virus. Therefore, many more, and better designed, studies will have to be conducted before the full clinical impact of immunosenescence can be delineated.

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Pneumocystis cariniiPneumonia in Adults without Predisposing Illnesses

Cited by 2 publications

References 7 publications

Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients

Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients

Immunosenescence Revisited

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