1940
DOI: 10.1084/jem.71.6.751
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I. Poliomyelitic Virus in Human Stools

Abstract: 1. The detection of the virus of poliomyelitis in 10 stools from 8 individuals is reported. All were in relation to epidemic poliomyelitis and 7 of them represented well recognized forms of the disease. The positive stools were distributed among 56 specimens collected from 53 persons in the first 4 weeks of illness. 2. The ease of detection of virus was directly related to the non-paralytic type of disease and inversely related to the age of the patients. 3. The negative results w… Show more

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Cited by 42 publications
(9 citation statements)
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“…It has been known for some time that poliomyelitis virus could be demonstrated in the faeces, but with the exception of Kling, Wernstedt and Pettersson (1911-12) who isolated the virus from this material with some regularity, the majority of workers obtained either negative or inconstant results. The recent studies of Paul and Trask and their colleagues in America have shown, however, that, given an adequate technique, the virus of poliomyelitis can be demonstrated in the stools of human cases with remarkable regularity (Trask, Vignec and Paul, 1938;Trask, Paul and Vignec, 1940;Melnick, 1943). What is more they have succeeded in isolating the virus from the sewage of urban communities in which poliomyelitis was epidemic (Paul, Trask and Gard, 1940).…”
Section: Section Of Neurologymentioning
confidence: 99%
“…It has been known for some time that poliomyelitis virus could be demonstrated in the faeces, but with the exception of Kling, Wernstedt and Pettersson (1911-12) who isolated the virus from this material with some regularity, the majority of workers obtained either negative or inconstant results. The recent studies of Paul and Trask and their colleagues in America have shown, however, that, given an adequate technique, the virus of poliomyelitis can be demonstrated in the stools of human cases with remarkable regularity (Trask, Vignec and Paul, 1938;Trask, Paul and Vignec, 1940;Melnick, 1943). What is more they have succeeded in isolating the virus from the sewage of urban communities in which poliomyelitis was epidemic (Paul, Trask and Gard, 1940).…”
Section: Section Of Neurologymentioning
confidence: 99%
“…It will withstand repeated freezing and thawing, extended storage at -70 C (6), and, if suspended in 50% glycerol, it will survive for years at 4 C (4). It will survive for hours in human feces at "high temperature," i.e., summer heat (12). The virus reportedly is not completely inactivated by a commercial disinfectant (polyethoxy-ethanoliodine), at a 1:200 dilution (recommended working concentration), when organic material is present (13).…”
mentioning
confidence: 99%
“…Experimental Methods Preparation of Sewage.--In general, the preparation of sewage samples for inoculation into monkeys has been based upon methods for the isolation of poliomyelitic virus from stools (1). The actual steps used in the adaptation of the stool method for use with sewage may be seen in Table I.…”
mentioning
confidence: 99%