<i>Porcine circovirus 3</i>
            in North and South America: Epidemiology and genetic diversity

Assao, Viviane Sisdelli; Santos, Marcelo Rocha dos; Pereira, Carlos Eduardo; Vannucci, Fábio A.; Silva-Júnior, Abelardo

doi:10.1111/tbed.14238

Cited by 10 publications

(17 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This supports the statement of genetic stability and low mutation rates of PCV3 (Arruda et al, 2019;Assao, Santos, Pereira, et al, 2021;Qi et al, 2019). All 44 Canadian sequences in this study were classified into clade 1 (PCV3a) along with included reference strains (Figure 1), which strengthens the hypothesis that clade 2 (PCV3b) including only two sequences is considered to be either recently emerged variants or the last descendant of previously circulating genotypes (Franzo et al, 2020).…”

Section: States Displaying Myocarditis Multisystemic Inflammation Por...supporting

confidence: 87%

“…protein and ORF3 encoding a protein with unknown functions (Assao, Santos, Pereira, et al, 2021;Klaumann et al, 2018;Palinski et al, 2017;Qi et al, 2019). The cap protein is considered to be the major structural protein, which determines the antigenic properties of the virus, showing only approximately 37% amino acid sequence identity to that of PCV2 (Nawagitgul et al, 2000;Palinski et al, 2017).…”

Section: States Displaying Myocarditis Multisystemic Inflammation Por...mentioning

confidence: 99%

“…The cap protein is considered to be the major structural protein, which determines the antigenic properties of the virus, showing only approximately 37% amino acid sequence identity to that of PCV2 (Nawagitgul et al, 2000;Palinski et al, 2017). PCV3 strains have shown genetic stability and low mutation rates over time and across countries, with nucleotide similarity ranging from 97% to 100% on partial or complete sequences (Assao, Santos, Pereira, et al, 2021;Assao, Santos, Rosado, et al, 2021;Franzo et al, 2020;Plut et al, 2020;Qi et al, 2019). This work aimed to investigate the genetic diversity of PCV3 strains circulating in Canada and whether a main PCV3 strain circulating across different Canadian provinces.…”

Section: States Displaying Myocarditis Multisystemic Inflammation Por...mentioning

confidence: 99%

See 2 more Smart Citations

Phylogenetic analysis of porcine circovirus 3 circulating in Canadian pigs

Zhang

Huang

et al. 2022

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Introduction Porcine circovirus 3 (PCV3) has been detected in pigs worldwide and associated with several clinical signs. Methods To investigate the genetic diversity of PCV3 strains circulating in Canada, 44 PCV3 positive samples from Saskatchewan (2/44), Manitoba (2/44), Quebec (4/44), Alberta (11/44) and Ontario (25/44) submitted to diagnostic laboratories in Canada between 2019 and 2021 were sequenced and analyzed. Results Phylogenetic analysis of capsid genes showed that all of the 44 Canadian strains classified into PCV3a and segregated into seven lineages with common amino acid changes observed at A24V, R27K, N56D, T77S, Q98R, L150I (F) and R168K positions. Conclusion Future studies are required to determine whether the polymorphisms in capsid proteins, as revealed in this study, could be associated with differences in the pathogenicity or antigenicity of PCV3 strains. This is the first phylogenetic analysis of PCV3 strains among different provinces in Canada.

show abstract

Section: States Displaying Myocarditis Multisystemic Inflammation Por...supporting

confidence: 87%

Section: States Displaying Myocarditis Multisystemic Inflammation Por...mentioning

confidence: 99%

Section: States Displaying Myocarditis Multisystemic Inflammation Por...mentioning

confidence: 99%

See 1 more Smart Citation

Phylogenetic analysis of porcine circovirus 3 circulating in Canadian pigs

Zhang

Huang

et al. 2022

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…Of note, co-infections of PCV4 with other PCV are common in swine herds. PCV2 causes PMWS and PDNS [ 1 ], and PCV3 may be associated with PDNS and reproductive failure [ 2 , 28 ]. Co-infections of PCV4 with PCV2, PCV3, or both, have been described in pigs with clinical signs of PMWS, PDNS and reproductive failure [ 4 , 11 , 12 ].…”

Section: Epidemiology Of Pcv4 and Clinical Diseases Associated With T...mentioning

confidence: 99%

Current knowledge on epidemiology and evolution of novel porcine circovirus 4

Wang

Mai

Yang

et al. 2022

Vet Res

View full text Add to dashboard Cite

Porcine circovirus type 4 (PCV4) is a newly emerging virus, with both PCV4 genomic DNA and specific antibodies detected in swine herds in several provinces in China and South Korea. Although the virus was first identified in 2019 in Hunan, China, retrospective research suggests that serum samples collected as early as 2008 were positive for PCV4 antibody. Infections with only PCV4 or co-infections with other pathogens have been associated with several clinical manifestations, but its pathogenesis remains to be determined. The purpose of this review was the following: (1) to characterize PCV4 epidemiology by assessing evolutionary dynamics and genetic diversity of PCV4 strains circulating in swine herds; (2) to reconstruct a computerized 3D model to analyze PCV4 Cap properties; (3) and to summarize the current evidence of PCV4-associated clinical-pathological manifestations. The origin of PCV4 is apparently distinct from other PCV, based on analysis of phylogenetic trees. Of note, PCV4 shares an ancient common ancestor with mink circoviruses. Furthermore, the amino acid residue at position 27 of the PCV4 Cap is a key benchmark to distinguish PCV4a (27S) from PCV4b (27 N), based on PCV4 strains currently available, and variation of this residue may alter Cap antigenicity. In addition, the capsid surface of PCV4 has characteristics of increased polar residues, compared to PCV2, which raises the possibility that PCV4 may target negatively charged host receptors to promote virus infection. Further studies are required, including virus isolation and culture, and more detailed characterization of molecular epidemiology and genetic diversity of PCV4 in swine herds.

show abstract

“…Porcine circovirus type 3 was first discovered in 2015, and since then, it has been found in many countries, including Asia, America, and Europe ( Ha et al, 2020 ; Saporiti et al, 2020 ; Assao et al, 2021 ). However, only a few research data have focused on the phylogeographic distribution and spread of PCV3 ( Arruda et al, 2019 ; Chen et al, 2019 ; Franzo et al, 2019b ; Jiang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of the Evolutionary Origin, Phylodynamics, and Phylogeography of the Porcine Circovirus Type 3

et al. 2022

View full text Add to dashboard Cite

Porcine circovirus type 3 (PCV3) is a newly identified virus associated with porcine dermatitis and nephropathy syndrome (PDNS) and multisystemic inflammatory responses in pigs. Recent studies suggests that PCV3 originated from bat circoviruses; however, the origin time, mode of spread, and geographic distribution of PCV3 remain unclear. In this study, the evolutionary origin, phylodynamics, and phylogeography of PCV3 were reconstructed based on the available complete genome sequences. PCV3 showed a closer relationship with bird circovirus than with bat circovirus, but their common ancestor was bat circovirus, indicating that birds may be intermediate hosts for the spread of circoviruses in pigs. Using the BEAST and phylogenetic analyses, three different clades of PCV3 (PCV3a, PCV3b, and PCV3c) were identified, with PCV3a being the most prevalent PCV3 clade. Further studies indicated that the earliest origin of PCV3 can be traced back to 1907.53–1923.44, with a substitution rate of 3.104 × 10–4 to 6.8524 × 10–4 substitution/site/year. A phylogeographic analysis highlighted Malaysia as the earliest location of the original PCV3, which migrated to Asia, America, and Europe. Overall, this study provides novel insights into the evolutionary origin, spread mode, and geographic distribution of PCV3, which will facilitate the prevention and control of PCV3 epidemics in the future.

show abstract

Porcine circovirus 3 in North and South America: Epidemiology and genetic diversity

Cited by 10 publications

References 46 publications

Phylogenetic analysis of porcine circovirus 3 circulating in Canadian pigs

Phylogenetic analysis of porcine circovirus 3 circulating in Canadian pigs

Current knowledge on epidemiology and evolution of novel porcine circovirus 4

Reconstruction of the Evolutionary Origin, Phylodynamics, and Phylogeography of the Porcine Circovirus Type 3

Contact Info

Product

Resources

About