<i>Poria cocos</i> oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis

Lan, Ke; Yang, Huabing; Zheng, Junping; Zhu, Tianxiang; Zou, Xiaojuan; Hu, Haiming; Liu, Hongtao

doi:10.1039/d2fo03424g

Cited by 17 publications

(9 citation statements)

References 64 publications

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“…These results indicated that gut microbiota was a key factor for colitis treatment of egg yolk lipids. It was also proved that Poria cocos oligosaccharides failed to prevent colitis in mice with gut microbiota depletion treated by antibiotic mixtures, [29] indicating the reliability of our results obtained by antibiotic treatment. Intestinal barrier dysfunction was a closely related pathogenic factor in IBD, and it even precedes and predicts the development of IBD.…”

Section: Discussionsupporting

confidence: 70%

Protective Effect of Egg Yolk Lipids against Dextran Sulfate Sodium‐Induced Colitis: The Key Role of Gut Microbiota and Short‐Chain Fatty Acids

Xiao,

He,

Chen

et al. 2024

Molecular Nutrition Food Res

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Egg yolk lipids significantly alleviate dextran sulfate sodium (DSS)‐induced colitis by inhibiting NLRP3 inflammasome, reversing gut microbiota dysbiosis, and increasing short chain fatty acids (SCFAs) concentrations. However, the role of gut microbiota and the relationship between SCFAs and NLRP3 inflammasome are still unknown. Here, this study confirms that antibiotic treatment abolishes the protective effect of egg yolk lipids on DSS‐induced colonic inflammation, intestinal barrier damage, and lipopolysaccharide translocation. Fecal microbiota transplantation also supports that egg yolk lipids alleviate colitis in a gut microbiota‐dependent manner. Then, the study investigates the relationship between SCFAs and NLRP3 inflammasome, and finds that SCFAs significantly suppress colitis via inhibiting colonic NLRP3 inflammasome activation and proinflammatory cytokines secretions (interleukin, IL)‐1β and IL‐18, and combined treatment of SCFAs and MCC950 (NLRP3 inhibitor) shows a better activity against colitis and NLRP3 inflammasome activation. Together, these findings provide positive evidence for gut microbiorta‐SCFAs‐NLRP3 axis as a novel target involving in the therapy of inflammatory bowel disease.

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Section: Discussionsupporting

confidence: 70%

Protective Effect of Egg Yolk Lipids against Dextran Sulfate Sodium‐Induced Colitis: The Key Role of Gut Microbiota and Short‐Chain Fatty Acids

Xiao,

He,

Chen

et al. 2024

Molecular Nutrition Food Res

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“… Kim et al (2018) reported improved visual acuity and disappearance of retinal and optic disk hemorrhages in patients with non-proliferative glycoconjugate network after administration of Poria -containing Modified-Goshajinkigan (Niucheshenqiwan in Chinese). Lan et al (2023b) found that Poria selectively modulated the abundance of Odoribacter , Muribaculum , Oscillibacter , E. coli , and Turicibacter , leading to a reduction of the inflammation levels caused by dextran sodium sulfate (DSS) in mice. Poria aqueous extract improves metabolic homeostasis and inflammation by restoring intestinal homeostasis, controlling the relationship between GM and host metabolites, modulating hypothalamic neurotransmitters, decreasing proinflammatory cytokines, and inhibiting the expression of TNF-α/NF-κB signaling pathway proteins.…”

Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 99%

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yu,

Liu,

Meng

2024

Front. Pharmacol.

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The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration of anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes in the composition, abundance, and diversity of the gut microbiota (GM). Activation of multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), and bile acids (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component and multi-target advantages, can help treat AMD by altering GM composition and regulating the levels of certain substances, such as lipopolysaccharides, reducing oxysterols, and increasing SCFA and BA contents. This review explores the correlation between GM and AMD and interventions for the two to provide new perspectives on treating AMD with TCM.

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“…CP is traditionally used to promote digestion, improve circulation, and regulate lipid metabolism [ 12 ]. WE is known for its sedative, diuretic, and spleen-boosting properties [ 26 ]. Recent studies have demonstrated that CP extracts, including polysaccharides, corosolic acid, hyperoside, and maslinic acid, protect against HFD-induced obesity and nonalcoholic fatty liver disease [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Yuan,

Hu,

Yang

et al. 2024

Foods

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Obesity is a multifactorial chronic metabolic disease with multiple complications. Crataegus pinnatifida (CP) and Wolfiporia extensa (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

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Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis

Abstract: PCOs could inhibit intestinal inflammation and restore gut barrier integrity in DSS-induced colitis mice. The gut microbiota plays a key role in colitis treatment using PCOs.

Cited by 17 publications

References 64 publications

Protective Effect of Egg Yolk Lipids against Dextran Sulfate Sodium‐Induced Colitis: The Key Role of Gut Microbiota and Short‐Chain Fatty Acids

Protective Effect of Egg Yolk Lipids against Dextran Sulfate Sodium‐Induced Colitis: The Key Role of Gut Microbiota and Short‐Chain Fatty Acids

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

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