<i>Prosopis cineraria</i>: A potential nootropic agent

Bithu, Bhawani S; Reddy, Nagannathahalli Ranga; Prasad, Shilpa; Krishnamurthy, Sairam; Hemalatha, S

doi:10.3109/13880209.2012.666253

Cited by 16 publications

(9 citation statements)

References 35 publications

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“…Results of total phenolic and flavonoidal content in current study also indicated their abundant existence in PC. Nootropic activity of methanolic extract of PC bark possesses antioxidant and AChE inhibition activity due to phenolic compounds ( Bithu et al, 2012 ). Our study shows BuPC have the highest potential for antioxidant and AChE inhibitory activity evaluated by in vitro DPPH assay and Ellman’s method, respectively, as compared to other fractions, which might be associated with the presence of rich amount of phenolic and flavonoid compounds.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding oral toxicity study, Bithu et al (2012) reported the safety of PC up to 2000 mg/kg, as there was no mortality and signs of toxicity in mice was observed by examining their behavioral status, such as convulsions, salivation, diarrhea, lacrimation and feeding behavior. No adverse effect was observed in vital organs, i.e., stomach, pancreas, eye and prostate gland, upto 31.5 mg/kg p.o.…”

Section: Discussionmentioning

confidence: 99%

“…It is also used for removal of hair from the skin by using wood ash ( Sharma et al, 2010 ). Tribal people used flowers of the plant with sugar to prevent miscarriage during pregnancy, whereas stem bark is consumed for memory enhancement and to increase the concentration power of mind ( Bithu et al, 2012 ). Different parts of PC are known to possess a number of therapeutic activities, e.g., antihyperglycemic, antihypercholesteremic ( Sharma et al, 2010 ), antitumour ( Robertson et al, 2011 ), analgesic ( Kumar et al, 2011 ), antibacterial ( Neghabi-Hajiagha et al, 2016 ), antioxidant and used in gastrointestinal, respiratory, and vascular disorders ( Janbaz et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia

et al. 2018

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Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system, have received more concern. Main focus of this study was to evaluate acute exposure of n-butanol fraction of Prosopis cineraria (L.) Druce hydroethanolic extract (BuPC) and green synthesized zinc oxide nanoparticles of BuPC (ZnOPC) on spatial cognition behavior, and to assess underlying mechanism by estimation of enzymatic antioxidative status along with acetylcholinesterase (AChE) activity in mice brain. Strongest in vitro antioxidant and AChE inhibitory activity exhibiting fraction, BuPC, was examined for inhibition kinetic study by Lineweaver–Burk and Dixon plots. BuPC was further used for fabrication ZnOPC and characterized by UV-visible spectroscopy, Fourier Transform Infrared (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X ray (EDX), and Dynamic Light Scattering (DLS) analysis. Old male swiss albino mice were randomly divided into seven groups and treated for 21 days. Subsequently spatial memory was determined by two behavioral models [Elevated plus maze (EPM) and Hebbs William maze (HWM)] and supernatant of brain homogenate was analyzed for enzymatic antioxidant level and AChE inhibitory activity. Zinc content of blood plasma and brain was estimated. Results showed prolonged transfer latency (TL) and time taken to reach reward chamber (TRC) by scopolamine was not ameliorated by the ZnOPC group, whereas BuPC group showed significant reduction in scopolamine induced increase in TL and TRC compared to control and scopolamine treated groups. ZnOPC alleviated enzymatic antioxidant activity and AChE as compared to donepezil and BuPC treated groups. Study concludes that ZnOPC attenuated spatial learning and memory by increase in oxidative stress and decrease in AChE activity at both dose levels. Our results suggest that BuPC exhibited a strong neuroprotective effect on cognitive deficit mice and it may be employed as a strong substance for the treatment of dementia whereas the green synthesized ZnOPC was not proficient to reverse the memory impairment induced by scopolamine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia

et al. 2018

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“…due to presence of various primary and secondary metabolites. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] There is no pharmacognostic data available on quantitation of urosolic acid and lupeol with respect to P. cineraria leaves to determine the physicochemical standards required for the future benefit of the crude drug. Urosolic acid and lupeol are the responsible for many of the pharmacological activities of this plant, so the main aim of the present investigation was to study the macroscopic, microscopic, physicochemical standards, antioxidant properties of this species.…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic Standardization and HPTLC Fingerprinting of Prosopis cineraria; An Ayurveda Mentioned Plant

Kulshreshtha¹,

Singh²

2019

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Background: Prosopis cineraria (P. cineraria) is an important mythological plant, popular in several indigenous systems of medicine including ayurveda, sidda and unani. Traditionally this plant is used for various ailments including anxiety, asthma, depression, epilepsy, hypertension, stress etc. Object: In the present study, macro and microscopic characters, physiochemical parameters, quantitave micros copy and phytochemical screening were done by using WHO guidelines. Anti-oxidant activity was assessed by DPPH method. HPTLC detec tion had been done to detect lupeol and urosolic acid and to quantify their relative levels. Result: Microscopy of the leaves showed the presence of different type of trichomes, stomata, calcium oxalate crystals, veins and epidermis. Total ash value, water soluble ash, acid soluble ash, water soluble extract, alcohol soluble extract, loss on drying, swelling index and foaming index were found to be 3.1±0.55, 2.1±0.43, 0.6±0.01 38.0±0.15, 37.8±1.50, 12.8±0.22, 1.4±0.02 and less than 100 respectively. Phytochemical analysis of different extracts showed the presence of alkaloids, glycosides, tannins, saponins, phenolic compounds etc. The IC 50 values found to be 2.63 and 12.1for the ethanolic and aqueous extracts of P. cineraria respectively. HPTLC analysis showed the presence of both of the standards, the amount of ursolic acid and lupeol was found to be 0.017% and 0.02% for each extract respectively. Conclusion: The data generated would be useful for the preparation of monograph of the plant as no such work reported yet.

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“…Due to the presence of various primary and secondary metabolites. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] There is a lack of scientific data on the proteins of this species and there analytical, antimicrobial and antioxidant activities. Hence, the present study was undertaken to assess the phytochemical content and screening the proteins for their microbiological and antioxidant properties as per WHO and standard guidelines.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the, Antimicrobial, Antioxidant Activity of Proteins from Prosopis cineraria Leaves

Kulshreshtha¹,

Shukla²,

Tiwari³

et al. 2019

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Introdutction:The present study was designed to screen out the different proteins from Prosopis cineraria (Leaves), known as Shammi (Family Fabaceae) and characterize them by IR, NMR and mass spectroscopy and evaluation of their antimicrobial potential against various microbial species. Mehtods: Different extracts of leaf were treated with different reagents for the presence and absence of metabolites. Antimicrobial effect of the proteins were explored against Staphylococcus aureus, Pseudomonas aeruginosa and Aspergillus tubingensis. The disc diffusion method was used for deter mination of antimicrobial activity. Analytical analysis included IR, NMR and Mass spectroscopy. Reults: Phytochemical analysis of different extracts showed the presence of different primary and secondary metabolites The range of zone of inhibition were found to be from 1.4±0.01mm to 14.2±0.18 mm. The maximum antimicrobial activity was found for 50 KDa protein against Pseudomonas aeruginosa.

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Prosopis cineraria: A potential nootropic agent

Abstract: The extract exerted significant nootropic activity in the MWM test which may be attributed to the inhibition of brain AChE.

Cited by 16 publications

References 35 publications

Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia

Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia

Pharmacognostic Standardization and HPTLC Fingerprinting of Prosopis cineraria; An Ayurveda Mentioned Plant

Characterization of the, Antimicrobial, Antioxidant Activity of Proteins from Prosopis cineraria Leaves

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