<i>Prumnopitys Andina</i> Fruit Extract Activates Liver X Receptors after In Vitro Digestion

Jiménez‐Aspee, Felipe; Pospiech, Jonas; Bauer, Sarah; Sus, Nadine; Kufer, Thomas A.; Frank, Jan

doi:10.1002/mnfr.202200377

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Jimenez-Aspee et al [52] prepared a Prumnopitys andina fruit extract and identified a series of phenolic compounds, including derivatives of hydroxycinnamic acids and flavonoids like shikimic acid, protocatechuic acid, caffeic acid, ferulic acid, apigenin, isorhamnetin, and quercetin (among others). These extracts were then used to determine whether they would affect the transcription of LXRα or LXRβ in HepG2 cells.…”

Section: Phenolic Extractsmentioning

confidence: 99%

Dietary Phenolic Compounds Exert Some of Their Health-Promoting Bioactivities by Targeting Liver X Receptor (LXR) and Retinoid X Receptor (RXR)

Domínguez-Avila

2023

Foods

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Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in gene expression being commonly reported. Nuclear receptors are signal transducers capable of regulating gene expression in response to endogenous and/or exogenous ligands. Liver X receptor (LXR) and retinoid X receptor (RXR) are two important nuclear receptors that can be acted on by phenolic compounds, thereby modifying gene expression and potentially exerting numerous subsequent bioactivities. The present work summarizes recent evidence of the effects of the phenolic compounds that are exerted by targeting LXR and/or RXR. The data show that, when LXR is being targeted, changes in lipid metabolism are commonly observed, due to its ability to regulate genes relevant to this process. The effects vary widely when RXR is the target since it is involved in processes like cell proliferation, vitamin D metabolism, and multiple others by forming heterodimers with other transcription factors that regulate said processes. The evidence therefore shows that phenolic compounds can exert multiple bioactivities, with a mechanism of action based, at least in part, on their ability to modulate the cell at the molecular level by acting on nuclear receptors. The data point to a promising and novel area of study that links diet and health, although various unknowns justify further experimentation to reveal the precise way in which a given phenolic can interact with a nuclear receptor.

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Section: Phenolic Extractsmentioning

confidence: 99%