<i>Pseudomonas aeruginosa</i>as a Potential Cause of Antibiotic-Associated Diarrhea

Kim, Shin‐Woo; Peck, Kyong Ran; Jung, Sook In; Kim, So Hyun; Kim, Sung-Min; Lee, Nam Yong; Song, Jae Hoon

doi:10.3346/jkms.2001.16.6.742

Cited by 39 publications

(30 citation statements)

References 9 publications

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“…Diarrhoea stopped 3 days after withdrawal of the offending antibiotics in two of the patients. Similar findings were seen in a previous study (Kim et al, 2001). In our study, six patients had overgrowth with Candida.…”

Section: Discussionsupporting

confidence: 81%

Diarrhoeagenic Escherichia coli as a predominant cause of paediatric nosocomial diarrhoea in India

Chandra

Singh

Taneja

et al. 2012

Journal of Medical Microbiology

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Intestinal nosocomial infections remain a major concern in paediatric wards leading to increased morbidity and mortality. This study determined the aetiological and epidemiological profile of nosocomial diarrhoea (ND) among children admitted to a hospital in India. During the period of January 2008 to June 2009, we consecutively enrolled 100 children between the age of 2 months and 14 years who developed ND as defined by the Centers for Disease Control and Prevention. A control group of patients matched for age and severity score but with no diarrhoea at admission or during their hospital stay (n550) were also enrolled. Stool samples were cultured for various pathogens using standard protocols. Clostridium difficile toxins and rotavirus antigen were detected using commercial ELISAs. Detection of diarrhoeagenic Escherichia coli was carried out by multiplex PCR assay. All patient details were noted. In this study, males predominated (77 %), and 56 % children were ,1 year of age and 96 % were ,5 years. The mean duration of diarrhoea and hospitalization in the case group was 3.2 days and 27.5 days, respectively. Malignancy and nasogastric tube usage were significant underlying factors for the development of ND. Diarrhoeagenic E. coli was the commonest agent (47 %: enterotoxigenic E. coli, enteroaggregative E. coli and enteropathogenic E. coli were isolated in 22, 18 and 7 % of patients, respectively). C. difficile toxin was seen in 9 % of cases, whilst rotavirus was found in 8 % of cases. Although rotavirus and C. difficile are major causative agents of hospital-acquired diarrhoea in the developed world, in this setting diarrhoeagenic E. coli was responsible for the majority of cases of hospital-acquired diarrhoea. ND was most common in children aged ,5 years.

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Section: Discussionsupporting

confidence: 81%

Diarrhoeagenic Escherichia coli as a predominant cause of paediatric nosocomial diarrhoea in India

Chandra

Singh

Taneja

et al. 2012

Journal of Medical Microbiology

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“…This bacterium has been found as part of the resident flora of the intestinal tract in some humans without causing infection [14,15]. Kim et al [16], in a study conducted in South Korea on seven patients, found an association between antibiotics used in diarrhea caused by strains of Pseudomonas aeruginosa resistant to same antibiotics that had been previously used by the patients, which suggests that Pseudomonas aeruginosa is a cause of diarrhea associated with the use of antibiotics; among the seven patients, one tested positive for Clostridium difficille toxins. In our study, of the 14 patients with a stool culture positive for Pseudomonas aeruginosa, six also had positive ELISA for Clostridium difficile.…”

Section: Discussionmentioning

confidence: 99%

Nosocomial diarrhea in the intensive care unit

Marcon¹,

Gamba²,

Vianna³

2006

Braz J Infect Dis

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We made an epidemiological case-control study to examine risk factors for the development of diarrhea in the intensive care unit (ICU) of a public hospital in Santo André, SP, from January to October 2002. Forty-nine patients with diarrhea (cases) and 49 patients without diarrhea (controls), matched for age and gender, were included in the study. A stool culture and enzyme immunoassays for Clostridium difficile toxins A and B were performed on fecal specimens from diarrhea patients.

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“…Gastrointestinal colonization with subsequent invasion into the bloodstream is the presumed mechanism underlying P. aeruginosa bacteremia in neutropenic patients. Diarrhea caused by P. aeruginosa has been observed almost exclusively in patients with prolonged antibiotic exposure (Kim et al, 2001). The development of antibiotic resistance is a serious side effect of current antipseudomonal treatments.…”

Section: Introductionmentioning

confidence: 99%

Lactic acid bacteria protect human intestinal epithelial cells from Staphylococcus aureus and Pseudomonas aeruginosa infections

Affhan¹,

Dachang²,

Xin³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Staphylococcus aureus and Pseudomonas aeruginosa are opportunistic pathogens that cause nosocomial and food-borne infections. They promote intestinal diseases. Gastrointestinal colonization by S. aureus and P. aeruginosa has rarely been researched. These organisms spread to extra gastrointestinal niches, resulting in increasingly progressive infections. Lactic acid bacteria are Gram-positive bacteria that produce lactic acid as the major end-product of carbohydrate fermentation. These bacteria inhibit pathogen colonization and modulate the host immune response. This study aimed to investigate the effects of Lactobacillus acidophilus and Lactobacillus rhamnosus on enteric infections caused by the paradigmatic human pathogens S. aureus ATCC25923 and P. aeruginosa ATCC27853. The effect of whole cells and neutralized cell-free supernatant (CFS) of the lactobacilli on LoVo human carcinoma enterocyte (ATCC CCL-229) infection was analyzed by co-exposure, pre-exposure, and post-exposure studies. Simultaneous application of whole cells and CFS of the lactobacilli significantly eradicated enterocyte infection (P < 0.05); however, this effect was not seen when the whole cells and CFS 17044-17058 (2015) were added after or prior to the infection (P > 0.05). This result could be attributed to interference by extracellular polymeric substances and cell surface hydrophobicity, which resulted in the development of a pathogen that did not form colonies. Furthermore, results of the plate count and LIVE/ DEAD BacLight bacterial viability staining attributed this inhibition to a nonbacteriocin-like substance, which acted independently of organic acid and H 2 O 2 production. Based on these results, the cell-free supernatant derived from lactobacilli was concluded to restrain the development of S. aureus and P. aeruginosa enteric infections.

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Pseudomonas aeruginosaas a Potential Cause of Antibiotic-Associated Diarrhea

Cited by 39 publications

References 9 publications

Diarrhoeagenic Escherichia coli as a predominant cause of paediatric nosocomial diarrhoea in India

Diarrhoeagenic Escherichia coli as a predominant cause of paediatric nosocomial diarrhoea in India

Nosocomial diarrhea in the intensive care unit

Lactic acid bacteria protect human intestinal epithelial cells from Staphylococcus aureus and Pseudomonas aeruginosa infections

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