<i>Pseudomonas aeruginosa</i>meningitis/ventriculitis in a UK tertiary referral hospital

Pai, Sumita; Bedford, Luke; Ruramayi, Rukini; Aliyu, Sani H.; Sule, Jumoke; Maslin, Douglas; Enoch, David

doi:10.1093/qjmed/hcv094

Cited by 31 publications

(27 citation statements)

References 20 publications

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“…MDR (multi-drug resistance) was de ned as acquired nonsusceptibility to at least one agent in three or more antimicrobial categories [15]. Pseudomonas meningitis was diagnosed when patients ful lled the following criteria: a positive P. aeruginosa culture of cerebrospinal uid (CSF) and clinical evidence of P. aeruginosa meningitis [16]. P. aeruginosa peritonitis was diagnosed when patients had clinical evidence of an intraabdominal source of infection and a positive ascitic uid culture with P. aeruginosa [32].…”

Section: De Nitionmentioning

confidence: 99%

Prognostic role of time to positivity of blood culture in children with Pseudomonas aeruginosa bacteremia.

Cheng

et al. 2020

Preprint

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Background Pseudomonas aeruginosa ( P. aeruginosa ) is a major Gram-negative pathogen, which has been reported to result in high mortality. We aim to investigate the prognostic value and optimum cut-off point of time-to-positivity (TTP) of blood culture in children with P. aeruginosa bacteremia. Methods From August 2014 to November 2018, we enrolled the inpatients with P. aeruginosa bacteremia in a 1500-bed tertiary teaching hospital in Chongqing, China retrospectively. 52 case were analyzed. Receiver operating characteristic (ROC) analysis was used to determine the optimum cut-off point of TTP, and logistic regression were employed to explore the risk factors for in-hospital mortality and septic shock. Results Totally, 52 children with P. aeruginosa bacteremia were enrolled. The standard cut-off point of TTP was18 hours. Early TTP (≤18 hours) group patients had remarkably higher in-hospital mortality (42.9% vs 9.7%, P=0.014), higher incidence of septic shock (52.4% vs 12.9%, P=0.06), higher Pitt bacteremia scores [3.00 (1.00-5.00) vs 1.00 (1.00-4.00), P=0.046] and more intensive care unit admission (61.9% vs 22.6%, P=0.008) when compared with late TTP (>18 hours) groups. Multivariate analysis indicated TTP ≤18 h, Pitt bacteremia scores ≥4 were the independent risk factors for in-hospital mortality (OR 5.88, 95%CI 1.21-21.96, P=0.035; OR 4.95, 95%CI 1.26-27.50, P=0.024; respectively). The study also revealed that the independent risk factors for septic shock were as follows: TTP≤18h, Pitt bacteremia scores≥4 and hypoalbuminemia (OR 6.30, 95%CI 1.18-33.77, P=0.032; OR 8.15, 95%CI 1.15-42.43, P=0.014; OR 6.46, 95% CI 1.19-33.19 P=0.031; respectively). Conclusions Early TTP (≤18 hours) appeared to be associated with worse outcomes for P. aeruginosa bacteremia children.

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Section: De Nitionmentioning

confidence: 99%

Prognostic role of time to positivity of blood culture in children with Pseudomonas aeruginosa bacteremia.

Cheng

et al. 2020

Preprint

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“…Терапия может проводить ся меропенемом или цефтазидимом в дозе 2 г каждые 8 ч. внутривенно [232], в комбинации (в соответствии с чувствительностью штамма) с ципрофлоксацином в дозе 400 мг каждые 8 ч. внутривенно или в режиме монотерапии. Среди других потенциально эффектив ных антибиотиков в случае чувствительности штамма следует рассмотреть применение фосфомицина в дозе 1624 г/сут, а также интратекальное или внутрижелу дочковое введение [233,234]…”

Section: клинические рекомендацииunclassified

Review of the Guidelines of the Spanish Society of Chemotherapy on antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa

Дехнич¹,

Belotserkovskiy²,

Веселов³

et al. 2018

CMAC

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Ввиду исключительной способности P. aeruginosa формировать устойчивость практически ко всем доступным антибактериальным препаратам, выбор режима терапии инфекций, вызванных данным микроорганизмом, представляет собой трудную задачу. Поэтому, на наш взгляд, большой интерес представляют опубликованные в 2018 г. в журнале «Revista Española de Quimioterapia» рекоменда ции Испанского общества по химиотерапии по лечению острых инвазивных инфекций, вызванных Pseudomonas aeruginosa. В данном обзоре изложены основные положения вышеуказанных реко мендаций.

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“…MDR (multi-drug resistance) was defined as acquired nonsusceptibility to at least one agent in three or more antimicrobial categories [15]. Pseudomonas meningitis was diagnosed when patients fulfilled the following criteria: a positive P. aeruginosa culture of cerebrospinal fluid (CSF) and clinical evidence of P. aeruginosa meningitis [16]. P. aeruginosa peritonitis was diagnosed when patients had clinical evidence of an intra-abdominal source of infection and a positive ascitic fluid culture with P. aeruginosa [32].…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of time to positivity of blood culture in children with Pseudomonas aeruginosa bacteremia.

Cheng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Pseudomonas aeruginosa (P. aeruginosa) is a major Gram-negative pathogen, which has been reported to result in high mortality. We aim to investigate the prognostic value and optimum cut-off point of time-to-positivity (TTP) of blood culture in children with P. aeruginosa bacteremia.Methods: From August 2014 to November 2018, we enrolled the inpatients with P. aeruginosa bacteremia in a 1500-bed tertiary teaching hospital in Chongqing, China retrospectively. Receiver operating characteristic (ROC) analysis was used to determine the optimum cut-off point of TTP, and logistic regression were employed to explore the risk factors for in-hospital mortality and septic shock.Results: Totally, 52 children with P. aeruginosa bacteremia were enrolled. The standard cut-off point of TTP was18 hours. Early TTP (≤18 hours) group patients had remarkably higher in-hospital mortality (42.9% vs 9.7%, P=0.014), higher incidence of septic shock (52.4% vs12.9%, P=0.06), higher Pitt bacteremia scores [3.00 (1.00-5.00) vs 1.00 (1.00-4.00), P=0.046] and more intensive care unit admission (61.9% vs 22.6%, P=0.008) when compared with late TTP (>18 hours) groups. Multivariate analysis indicated TTP ≤18 h, Pitt bacteremia scores ≥4 were the independent risk factors for in-hospital mortality (OR 5.88, 95%CI 1.21-21.96, P=0.035; OR 4.95, 95%CI 1.26-27.50, P=0.024; respectively). The independent risk factors for septic shock were as follows: TTP ≤18h, Pitt bacteremia scores ≥4 and hypoalbuminemia (OR 6.30, 95%CI 1.18-33.77, P=0.032; OR 8.15, 95%CI 1.15-42.43, P=0.014; OR 6.46, 95% CI 1.19-33.19 P=0.031; respectively).Conclusions: Early TTP (≤18 hours) appeared to be associated with worse outcomes for P. aeruginosa bacteremia children.Trial registration: Retrospectively registered. File No. (2019)304

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Pseudomonas aeruginosameningitis/ventriculitis in a UK tertiary referral hospital

Cited by 31 publications

References 20 publications

Prognostic role of time to positivity of blood culture in children with Pseudomonas aeruginosa bacteremia.

Prognostic role of time to positivity of blood culture in children with Pseudomonas aeruginosa bacteremia.

Review of the Guidelines of the Spanish Society of Chemotherapy on antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa

Prognostic role of time to positivity of blood culture in children with Pseudomonas aeruginosa bacteremia.

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