Punica granatum Peel Extract Ameliorates Doxorubicin Induced Cardiotoxicity

Punica granatum L. Extract Shows Cardioprotective Effects Measured by Oxidative Stress Markers and Biomarkers of Heart Failure in an Animal Model of Metabolic Syndrome

“…Especially in terms of the protein thiol group concentration (SH), the molecules marked by the capacity to neutralize the reactive oxygen species were increased in MetS rats treated with pomegranate peel extract in a dose-dependent manner. Data also suggest that ethanolic peel extract increased glutathione disulfide redox buffer in doxorubicin-induced cardiotoxicity [ 63 ]. The antioxidative potential of the pomegranate peel extract also enforced an upward tendency inCAT, GPX, and GST activity observed in the rats treated with lower doses, which arise from their mechanism of action.…”

“…The upregulation of myocardial expression of endothelial nitric oxide synthase (eNOS), activating nitric-oxide-mediated Nrf2, was concluded to be responsible for the cardioprotection of extract treatment [ 67 ]. Similarly, Punica granatum L. peel tended to protect the myocardium against toxic agents, demonstrated by the mitigation of ECG disturbances and biochemical parameters [ 63 , 65 ]. Contrary to these outcomes, we did not observe a marked alternation of cTnI level in the rats treated with ethanolic extract.…”

“…Evidence has shown that pomegranate peel extract can reduce the hypertrophied coronary arterial walls induced via the downregulation of angiotensin-converting enzyme activity (ACE) [ 69 ]. Of note, referring to cardiac muscle, phenolic extract from peels improved myofibril composition via the reduction in separated and disorientated muscle fibers with pyknotic nuclei, inhibition in cytoplasmatic lipid deposition, and vacuolar degeneration of cardiomyocytes [ 63 , 67 , 74 ]. In our study, histopathological data revealed considerable alternation, such as parenchymal degeneration in heart sections and fiber displacement in the aorta cross-sectional area in all the groups of rats, which are linked to the course of metabolic imbalance, especially co-occurring obesity and diabetes mellitus in MetS.…”

Pomegranate: Nutraceutical with Promising Benefits on Human Health

“…Concerning the histopathological morphology, the only assumption was that doxorubicin modified myocardium through vacuolar alterations in the heart muscle and necrosis of heart muscle with remote cells increasing in the size in between the necrotic and fragmented muscle fibers. Instead, treatment with P. granatum peel extract displayed a protective effect with less histological changes such as irregular and spread vacuolation limited to subendocardial layers [120].…”