<i>Punica Granatum</i>
            with Multiple Effects in Chronic Diseases

Doostkam, Aida; Bassiri-Jahromi, Shahindokht; Iravani, Kamyar

doi:10.1080/15538362.2019.1653809

Cited by 18 publications

(8 citation statements)

References 100 publications

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“…On the other hand, phenolics, especially anthocyanins, have been reported to be highly correlated with antioxidant activity in pomegranate arils [14,16,34]. They are compounds responsible for the health benefits attributed to the consumption of pomegranate fruit [4][5][6][47][48][49][50]. Therefore, preharvest GABA treatments would lead to pomegranates with enhanced health-beneficial effects.…”

Section: Discussionmentioning

confidence: 99%

Preharvest Multiple Applications of GABA Improve Quality Traits and Antioxidant Compounds of Pomegranate Fruit during Storage

et al. 2023

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GABA (γ-Aminobutyric acid) is an amino acid with diverse effects on plant development, including delayed senescence in horticultural commodities. The main goal of this research was to investigate the impact of GABA applications to pomegranate trees on the ‘Mollar de Elche’ quality traits and antioxidant compounds during storage for 60 days at 10 °C. In the 2019 experiment, pomegranate trees received foliar sprays of GABA at 10-, 50- or 100-mM concentrations at three stages of fruit development. Pomegranates harvested from GABA-treated trees exhibited enhanced fruit firmness, titratable acidity, the red color of skin and aril, and higher levels of total phenolics and total and specific anthocyanins compared to those obtained from the control group. These quality traits were maintained at higher levels during 60 days of preservation at 10 °C, and the most important effects were observed for 100 mM dose. In a 2020 experiment, GABA was sprayed at a 100 mM dose, and results were confirmed, showing a retard of the ripening process in pomegranates from GABA-treated trees concerning controls for two months of storage and an extension of their shelf life (with optimal quality traits appreciated by consumers) from 30 to 60 days. Moreover, the increase in anthocyanin content due to GABA treatments resulted in redder fruits, which would appeal more to consumers and have improved health benefits.

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Section: Discussionmentioning

confidence: 99%

Preharvest Multiple Applications of GABA Improve Quality Traits and Antioxidant Compounds of Pomegranate Fruit during Storage

et al. 2023

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“…Pomegranate fruit have a wide range of bioactive compounds, the most important being phenolics, including anthocyanins, hydrolysable tannins and other complex flavonoids, and ascorbic acid, which are found at high concentrations as compared with other fruits of the Mediterranean diet, although different contents have been reported depending on cultivar, ripening stage, cultural practices and environmental conditions [ 12 , 15 , 19 , 36 ]. These bioactive compounds have antioxidant capacity and are responsible for the health beneficial effects attributed to pomegranate fruit consumption [ 4 , 6 , 7 , 8 , 10 ]. Results of the present experiments show that preharvest melatonin treatments enhanced total phenolic compound and total and individual anthocyanin concentrations at harvest, leading to increases in H-TAA, with these effects being maintained during storage.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 ]. These and other health beneficial effects against several diseases, such as atherosclerosis, inflammatory and infective-mediated diseases, Alzheimer, diabetes, infarct brain ischemia and several types of cancer, have been scientifically proven recently and attributed to its content of anthocyanins and other phenolic compounds [ 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Anthocyanins are the pigments responsible for skin and aril colour and in both tissues, increases occur during maturation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Treatment to Pomegranate Trees Enhances Fruit Bioactive Compounds and Quality Traits at Harvest and during Postharvest Storage

et al. 2021

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The effect of melatonin pomegranate tree treatments on fruit quality and bioactive compounds with antioxidant activity at harvest and during storage at 10 °C for 60 days was assayed in two consecutive years, 2019 and 2020. In the first year, trees were treated with 0.1, 0.3 and 0.5 mM of melatonin along the developmental fruit growth cycle, and results showed that bioactive compounds (total phenolics and total and individual anthocyanins) and antioxidant activity at harvest were higher in fruits from melatonin-treated trees than in controls. Other fruit quality parameters, such as firmness, total soluble solids and aril red colour, were also increased as a consequence of melatonin treatment. In fruit from control tress, firmness and acidity levels decreased during storage, while increases occurred on total soluble solids, leading to fruit quality reductions. These changes were delayed, and even maintenance of total acidity was observed, in fruit from melatonin-treated trees with respect to controls, resulting in a fruit shelf-life increase. Moreover, concentration of phenolics and anthocyanins and antioxidant activity were maintained at higher levels in treated than in control fruits during the whole storage period. In general, all the mentioned effects were found at the highest level with the 0.1 mM melatonin dose, and then it was selected for repeating the experiment in the second year and results of the first year were confirmed. Thus, 0.1 mM melatonin treatment could be a useful tool to enhance aril content on bioactive compounds with antioxidant activity and health beneficial effects and to improve quality traits of pomegranate fruit, at harvest and during postharvest storage.

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“…More than 90% of diabetic patients with diabetes are afflicted by type 2 diabetes mellitus (T2DM). In type 2 diabetes, elevated plasma glucose and free fatty acid levels lead to oxidative stress, β-cell dysfunction, insulin resistance, and metabolic syndrome [2,3]. One of the manifestations of these cellular and molecular disorders is a nonalcoholic fatty liver disease (NAFLD), a chronic liver disease [4].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats

Doostkam

Fathalipour

Anbardar

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

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Background. At present, nonalcoholic fatty liver disease (NAFLD) does not have an approved pharmacologic therapy. The present study investigated the protective effects and possible mechanisms of milk thistle (Silybum marianum L.) and artichoke (Cynara scolymus L.) in treating NAFLD in type 2 diabetic rats. Methods. The NAFLD was established in rats after four weeks of type 2 diabetes induction. The animals were treated with pharmaceutical preparations of milk thistle (Livergol®) and artichoke (Atheromod-B®) extracts for eight weeks. After the end of the intervention, oral glucose tolerance, the serum parameters of oxidative stress, liver functional tests, and lipid profiles were evaluated. Histopathological changes were assessed by hematoxylin and eosin staining. Results. Treatment with preparations of milk thistle and artichoke nonsignificantly improved glucose tolerance in diabetic rats. Both preparations significantly improved serum superoxide dismutase activity and the level of malondialdehyde. Although treatment with milk thistle reduced serum activity of aspartate aminotransferase and serum levels of triglyceride (TG), total cholesterol, and low-density lipoprotein-cholesterol, artichoke extracts only attenuated the serum level of TG. Milk thistle also effectively protected the liver from histological changes. Conclusions. Milk thistle could be a promising pharmacological option for the treatment of NAFLD. Nonetheless, long-term randomized clinical trials are necessary to confirm the observed results.

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Punica Granatum with Multiple Effects in Chronic Diseases

Cited by 18 publications

References 100 publications

Preharvest Multiple Applications of GABA Improve Quality Traits and Antioxidant Compounds of Pomegranate Fruit during Storage

Preharvest Multiple Applications of GABA Improve Quality Traits and Antioxidant Compounds of Pomegranate Fruit during Storage

Melatonin Treatment to Pomegranate Trees Enhances Fruit Bioactive Compounds and Quality Traits at Harvest and during Postharvest Storage

Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats

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