(<i>R</i>)-8-Methylsulfinyloctyl isothiocyanate from <i>Nasturtium officinale</i> inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved

Alcarranza, Manuel; Villegas, Isabel; Recio, Rocío; Muñoz-García, Rocío; Fernández, Inmaculada; Lastra, Catalina Alarcón de la

doi:10.1039/d3fo02009f

Cited by 3 publications

(1 citation statement)

References 88 publications

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“…The JAK-STAT signaling pathway is a transmembrane signaling pathway that enables cells to communicate with the outside world, and the activation of the pathway is tightly linked to the onset and progression of many inflammatory diseases. 43,44 A number of cytokines, such as interferon (IFN), interleukins, and growth factors, have been found to bind to their corresponding transmembrane receptors, resulting in the activation of JAK kinases coupled to the receptors. Phosphorylated JAK phosphorylates tyrosine residues on the receptor, which attracts STAT proteins containing the SH2 structural domain for specific binding.…”

Section: Discussionmentioning

confidence: 99%

Bound polyphenols in insoluble dietary fiber of navel orange peel modulate LPS-induced intestinal-like co-culture inflammation through CSF2-mediated NF-κB/JAK-STAT pathway

Chang,

Zheng,

Guo

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Bound polyphenols in insoluble dietary fiber of navel orange peel modulate LPS-induced intestinal-like co-culture inflammation through CSF2-mediated NF-κB/JAK-STAT pathway

Chang,

Zheng,

Guo

et al. 2024

Food Funct.

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Potential therapeutic and ameliorative effects of ramipril alone and in combination with methylprednisolone for the cytokine releasing syndrome in mice: An in vivo study

Al-Naimi,

Abu-Raghif

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Immunomodulatory Effects and Regulatory Mechanisms of (R)-6-HITC, an Isothiocyanate from Wasabi (Eutrema japonicum), in an Ex Vivo Mouse Model of LPS-Induced Inflammation

Alcarranza,

Alarcón-de-la-Lastra,

Recio Jiménez

et al. 2024

J. Agric. Food Chem.

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The present study aimed to investigate the effects of (R)-(−)-1-isothiocyanato-6-(methylsulfinyl)-hexane [(R)-6-HITC], the major isothiocyanate present in wasabi, in an ex vivo model of inflammation using lipopolysaccharide-stimulated murine peritoneal macrophages. (R)-6-HITC improved the immune response and mitigated oxidative stress, which involved suppression of reactive oxygen species, nitric oxide, and pro-inflammatory cytokines (IL-1β, IL-6, IL-17, IL-18, and TNF-α) production and downregulation of pro-inflammatory enzymes such as inducible nitric oxide synthase, COX-2, and mPGES-1. In addition, (R)-6-HITC was able to activate the Nrf2/HO-1 axis while simultaneously inhibiting key signaling pathways, including JAK2/STAT3, mitogen-activated protein kinases, and canonical and noncanonical inflammasome pathways, orchestrating its potent immunomodulatory effects. Collectively, these findings demonstrate the potential of (R)-6-HITC as a promising nutraceutical for the management of immuno-inflammatory diseases and justify the need for further in vivo validation studies.

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(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved

Abstract: Hirsutin, synthesized in a novel way by the “DAG methodology”, showed antioxidant and anti-inflammatory effects in immune murine cells.

Cited by 3 publications

References 88 publications

Bound polyphenols in insoluble dietary fiber of navel orange peel modulate LPS-induced intestinal-like co-culture inflammation through CSF2-mediated NF-κB/JAK-STAT pathway

Bound polyphenols in insoluble dietary fiber of navel orange peel modulate LPS-induced intestinal-like co-culture inflammation through CSF2-mediated NF-κB/JAK-STAT pathway

Potential therapeutic and ameliorative effects of ramipril alone and in combination with methylprednisolone for the cytokine releasing syndrome in mice: An in vivo study

Immunomodulatory Effects and Regulatory Mechanisms of (R)-6-HITC, an Isothiocyanate from Wasabi (Eutrema japonicum), in an Ex Vivo Mouse Model of LPS-Induced Inflammation

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