(<i>R</i>,<i>S</i>)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway

Giménez-Bastida, Juan Antonio; Ávila-Gálvez, María Ángeles; Martínez-López, Alicia; García-Moreno, Diana; Espín, Juan Carlos; González-Sarrías, Antonio

doi:10.1039/d3fo03946c

Food Funct.

2024

DOI: 10.1039/d3fo03946c

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(R,S)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway

Juan Antonio Giménez-Bastida,

María Ángeles Ávila-Gálvez,

Alicia Martínez-López

et al.

Abstract: Dietary isoflavones, genistein and daidzein, and their derived microbial metabolites, including equol and equol 7-β-d-glucuronide, target the VEGFR2 pathway and modulate processes related to angiogenesis.

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Perspective on the Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health

Espín,

Jarrín‐Orozco,

Osuna‐Galisteo

et al. 2024

Molecular Nutrition Food Res

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Abstract“Personalized nutrition” aims to establish nutritional strategies to improve health outcomes for non‐responders. However, it is utopian since most people share similar nutritional requirements. “Precision health,” encompassing lifestyles, may be more fitting. Dietary (poly)phenols are “healthy” but non‐nutritional molecules (thus, we can live without them). The gut microbiota influences (poly)phenol effects, producing metabolites with different activity than their precursors. Furthermore, producing distinctive metabolites, like urolithins, lunularin, and equol, leads to the term “polyphenol‐related gut microbiota metabotypes,” grouping individuals based on a genuine microbial metabolism of ellagic acid, resveratrol, and isoflavones, respectively. Additionally, (poly)phenols exert prebiotic‐like effects through their antimicrobial activities, typically reducing microbial diversity and modulating microbiota functionality by impacting its composition and transcriptomics. Since the gut microbiota perceives (poly)phenols as a threat, (poly)phenol effects are mostly a consequence of microbiota adaptation through differential (poly)phenol metabolism (e.g., distinctive reductions, dehydroxylations, etc.). This viewpoint is less prosaic than considering (poly)phenols as essential nutritional players in human health, yet underscores their health significance in a coevolutionary partnership with the gut microbiota. In the perspective on the gut microbiota and (poly)phenols interplay, microbiota metabotypes could arbiter health effects. An innovative aspect is also emphasized: modulating the interacting microbial networks without altering the composition.

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Perspective on the Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health

Espín,

Jarrín‐Orozco,

Osuna‐Galisteo

et al. 2024

Molecular Nutrition Food Res

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show abstract

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(R,S)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway

Abstract: Dietary isoflavones, genistein and daidzein, and their derived microbial metabolites, including equol and equol 7-β-d-glucuronide, target the VEGFR2 pathway and modulate processes related to angiogenesis.

Cited by 1 publication

References 79 publications

Perspective on the Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health

Perspective on the Coevolutionary Role of Host and Gut Microbiota in Polyphenol Health Effects: Metabotypes and Precision Health

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