rac-(3S,4S)-3-Hydroxy-4-phenyl-1-[(S)-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)methyl]-4,5-dihydro-1H-1,5-benzodiazepin-2(3H)-one

Abstract

In the title compound, C25H23N3O3, the seven-membered diazepine ring adopts a boat conformation with the hydroxy-substituted C atom at the prow and fused-ring C atoms at the stern. The crystal packing features C—H⋯O, C—H⋯π and N—H ⋯π inter­actions

5-Acetyl-3-hydroxy-4-phenyl-4,5-dihydro-1H-1,5-benzodiazepin-2(3H)-one

“…The report on 3-hydroxy-4-phenyl-1-[(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)methyl]-4,5-dihydro-1H-1,5benzodiazepin-2(3H)-one provides the preparation and biological activity of this class of benzodiazepin-2-ones (Rida et al, 2011). In the present study, the reactant, 3-ydroxy-4-phenyl-4,5-dihydro-1H-1,5-benzodiazepin-2(3H)-one, has two amino -NH-units in the ring system; however, only one site is acetylated when the compound is treated with acetic anhydride.…”